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Urinary ORM-2 and sCD14 levels were increased in patients with Rheumatoid Arthritis and were correlated with the disease activity.
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Studies suggest plasma alpha-1-acid glycoprotein (AAG) as a potential predictive biomarker of docetaxel non-haematological AEs namely oral mucositis and rash.
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the glycosylation change of alpha-1-acid glycoprotein (AGP) in hepatocellular carcinoma (HCC), cirrhosis and controls
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Neural cell interactions are important for brain physiology and pathology. Particularly, the interaction between non-neuronal cells plays a central role in regulating brain inflammation, which is closely linked to many brain disorders. Here, we newly identified orosomucoid-2 (ORM2) as an endogenous protein that mediates such non-neuronal glial cell interactions
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Low ORM2 expression is associated with metastasis in hepatocellular carcinoma.
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Data suggest that human serum albumin (HSA) might serve as a carrier in delivering chitooligomers to target tissues than alpha-1-glycoprotein (AGP) which has pharmacological importance.
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Identify ORM genetic variations/haplotype structure associated with serum alpha-1-acid glycoprotein level and the pharmacokinetics of paclitaxel in Japanese cancer patients.
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Data indicate that the band intensity of sialic acid content in alpha-1 Acid glycoprotein (AGP) of alcoholic liver cirrhosis was found to be lower than that in pooled control group.
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These findings suggest that the ORM distal promoter region differentially regulates expression of ORM genes at basal level and in acute phase responses.
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Alteration in expression of ORM2 suggests that ORM2 could be used as a potential biomarker in the diagnosis of colorectal cancer.
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Characterized are more than 150 human Alpha-1-acid glycoprotein isoforms, differing both in the amino acid sequence and in the glycosylation.
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folds as a highly symmetrical all-beta protein dominated by a single eight-stranded antiparallel beta-sheet
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the sera of patients with acute inflammation demonstrated increased numbers of bi-antennary and alpha1,3-fucosylated N-glycan structures at each glycosylation site
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The binding of coumarin enantiomers to ORM2 is studied.
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Results describe the thermal unfolding and reversibility of temperature-induced changes in alpha(1)-acid glycoprotein.
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A different distribution of the area percentage of AGP forms is observed when comparing samples from diseased and healthy individuals, the most acidic AGP forms being present in a higher proportion in the samples from cancer patients.
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The results indicate that, in accordance with prior expectations, the ORM2 variant is responsible for the acute-phase property of alpha-1 acid glycoprotein.
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structure of the alpha1-acid glycoprotein (AGP), or orosomucoid (ORM), gene was investigated in a Ghanaian mother and her child, who shared an unusual variant, ORM1 S2(C), found by isoelectric focusing
