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protects cells against oxidative stress; may play a role in nucleolar organization or function.
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Cow (Bovine) Polyclonal OXR1 Primary Antibody for WB - ABIN2774200
Durand, Kolpak, Farrell, Elliott, Shao, Brown, Volkert: The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins. in BMC cell biology 2007
Human Polyclonal OXR1 Primary Antibody for IHC, IHC (p) - ABIN4342112
Hebert, Bellanger, Guillas, Campagne, Dingli, Loew, Fievet, Jacquemin, Popova, Jean, Mechta-Grigoriou, Margueron, Stern: Modulating BAP1 expression affects ROS homeostasis, cell motility and mitochondrial function. in Oncotarget 1970
OXR1 may act as a sensor of cellular oxidative stress to regulate the transcriptional networks required to detoxify reactive oxygen species and modulate cell cycle and apoptosis.
Oxr1 serves as a potential therapeutic target for ALS (show IGFALS Antibodies) and other neurodegenerative disorders characterized by TDP-43 (show TARDBP Antibodies) or FUS (show FUS Antibodies) pathology.
OXR1 upregulates the expression of antioxidant genes via the p21 (show CDKN1A Antibodies) signaling pathway to suppress hydrogen peroxide-induced oxidative stress and maintain mtDNA integrity.
The protein segment encoded by exon 8 plays an important role in the anti-oxidative function of the human OXR1 protein.
Data show that human and yeast oxidation resistance 1 (OXR1) genes are induced by heat and oxidative stress and that their proteins localize to the mitochondria and function to protect against oxidative damage.
human OXR1 is capable of reducing the DNA damaging effects of reactive oxygen species when expressed in bacteria, indicating the protein has an activity that can contribute to oxidation resistance.
Treatment with the orexin (show OX Antibodies)-1 receptor antagonist SB334867 increased the activity of basolateral amygdala neurons projecting to infralimbic medial prefrontal cortex during fear extinction. GABAergic interneurons expressing calbindin (show CALB1 Antibodies), but not parvalbumin (show PVALB Antibodies), were also activated by orexin (show OX Antibodies)-1 receptor antagonism in the basolateral amygdala.
screening a panel of proteins that regulate mitochondrial morphology in bella GCs (show UGCG Antibodies) revealed de-regulation of phospho-Drp1 (show CRMP1 Antibodies)(Ser616), a key mitochondrial fission regulatory factor. Our data provide new insights into the function of Oxr1, revealing that specific isoforms of this novel antioxidant protein (show PRDX3 Antibodies) are associated with mitochondria.
identify OXR1 as the first neuron-specific antioxidant modulator of pathogenesis and disease progression in SOD1 (show SOD1 Antibodies)-mediated amyotrophic lateral sclerosis
up-regulation of Oxr1 in both human and pre-symptomatic mouse models of amyotrophic lateral sclerosis, indicating that Oxr1 is potentially a novel neuroprotective factor in neurodegenerative disease
The patterns of Oxr1 expression observed suggest that the gene is associated with resistance to hyperoxic challenge and that it acts at the level of the outer segment.
protects cells against oxidative stress\; may play a role in nucleolar organization or function
oxidation resistance 1
, oxidation resistance protein 1
, oxidation resistance protein 1-like
, TBC/LysM-associated domain containing 3
, putative protein product of Nbla00307
, nucleolar protein C7
, protein C7
, hypothetical protein