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OSGIN1 encodes an oxidative stress response protein that regulates cell death.
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The results support the concept that smoking-induced upregulation of OSGIN1 is one link between smoking-induced stress and enhanced-autophagy in the human airway epithelium.
miR (show MLXIP ELISA Kits)-320a has a role in modulating the induction of HO-1 (show HMOX1 ELISA Kits), GCLM (show GCLM ELISA Kits) and OKL38 by oxidized phospholipids in endothelial cells
Identify OSGIN1 as a tumor suppressor that is down-regulated or altered in human hepatocellular carcinoma.
Data suggest that OKL38 regulates mitochondria morphology and functions during apoptosis together with p53 (show TP53 ELISA Kits).
BDGI (Bone marrow stromal cell-derived growth inhibitor) inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis [BDGI]
The 5'UTRs of OKL38 might play an important role in downregulation of its protein and the absence of OKL38 could lead to the development or progression of hepatocellular carcinoma.
identify OKL38 as a novel p53 target gene that is regulated by Peptidylarginine deiminase 4 and plays a role in apoptosis
This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product.
oxidative stress induced growth inhibitor 1
, pregnancy-induced growth inhibitor
, oxidative stress-induced growth inhibitor 1-like
, oxidative stress-induced growth inhibitor 1
, bone marrow stromal cell-derived growth inhibitor
, ovary, kidney and liver protein 38
, pregnancy-induced growth inhibitor OKL38