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The protein encoded by OXM is actually a preproprotein that is cleaved into four distinct mature peptides. Additionally we are shipping Oxyntomodulin Kits (21) and Oxyntomodulin Proteins (3) and many more products for this protein.
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This review summarizes the current knowledge regarding the role of GLP-1 (show GCG Antibodies) in the protection against oxidative damage and the activation of the Nrf2 (show GABPA Antibodies) signaling pathway. [review]
Study concludes that in healthy subjects, glucagon-like peptide-1 (GLP-1 (show GCG Antibodies)) increases cardiac output acutely due to a GLP-1 (show GCG Antibodies)-induced vasodilation in adipose tissue and skeletal muscle together with an increase in cardiac work.
Chenodeoxycholic acid stimulates glucagon-like peptide-1 (show GCG Antibodies) secretion in patients after Roux-en-Y gastric bypass.
The results demonstrate that glucagon-like peptide-1 (show GCG Antibodies) and insulin (show INS Antibodies) synergistically and additively activate vagal afferent neurons.
DPP-4 (show DPP4 Antibodies) activity and GLP (show RCBTB1 Antibodies)-1total levels were higher in patients with microvascular complications associated with T2DM. Contrary to expectations, no negative correlation was seen between GLP-1 (show GCG Antibodies) and DDP (show TIMM8A Antibodies)-4 levels. This result suggests the possible inefficacy of DDP (show TIMM8A Antibodies)-4 activity as a marker to predict in vivo degradation of endogenous GLP-1 (show GCG Antibodies).
Data suggest that cAMP acts as amplifier of insulin (show INS Antibodies) secretion triggered by Ca2 (show CA2 Antibodies)+ elevation in beta-cells; both messengers are also positive modulators of glucagon (show GCG Antibodies) release from alpha-cells, but in this case cAMP signaling may be the important regulator and Ca2 (show CA2 Antibodies)+ signaling has a more permissive role. [REVIEW]
This study provides evidence that, in HepG2 cells, GLP-1 (show GCG Antibodies) may affect cholesterol homeostasis by regulating the expression of miR (show MLXIP Antibodies)-758 and ABCA1 (show ABCA1 Antibodies).
This study reports the transition dipole strengths and frequencies of the amyloid beta-sheet amide I mode for the aggregated proteins amyloid-beta1-40, calcitonin (show CALCA Antibodies), alpha-synuclein, and glucagon (show GCG Antibodies).
genetic association studies in population in China: Data confirm that an SNP in an intron of SLC47A1 (show SLC47A1 Antibodies) (rs2289669) is associated with hypoglycemic response to metformin in patients with newly diagnosed type 2 diabetes; differential increases in basal GLP1 (show GCG Antibodies) plasma levels are also related to this SNP. (SLC47A1 (show SLC47A1 Antibodies) = solute carrier family 47 member 1 (show SLC47A1 Antibodies); GLP1 (show GCG Antibodies) = glucagon-like peptide-1 (show GCG Antibodies))
GLP-2 (show GCG Antibodies) augmented BRIN BD11 (show DEFB110 Antibodies) beta-cell proliferation, but was less efficacious in 1.1B4 cells. These data highlight the involvement of GLP-2 receptor (show GLP2R Antibodies) signalling in the adaptations to pancreatic islet cell stress.
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
, glucagon-like peptide 1
, glucagon-like peptide 2