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Oxysterol Binding Protein-Like 5 Proteins (OSBPL5)

OSBPL5 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Additionally we are shipping Oxysterol Binding Protein-Like 5 Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat OSBPL5 OSBPL5 361686  
OSBPL5 114879 Q9H0X9
OSBPL5 79196 Q9ER64
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Top Oxysterol Binding Protein-Like 5 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 60 to 65 Days
$10,699.55
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$7,506.65
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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OSBPL5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Oxysterol Binding Protein-Like 5 (OSBPL5) Interaction Partners

Cow (Bovine) Oxysterol Binding Protein-Like 5 (OSBPL5) interaction partners

  1. imprinting status of four cattle genes (Tssc4,Nap1l4, Phlda2 and Osbpl5) in seven types of tissues, were assessed in cattle.

Human Oxysterol Binding Protein-Like 5 (OSBPL5) interaction partners

  1. Data suggest that ORP5/OSBPL5 promotes cell proliferation, cell motility, and invasiveness of neoplasm cells; this effect of ORP5/OSBPL5 depends on functional OSBP-related domain (ORD). ORP5/OSBPL5 is needed for activation of mTORC1 signaling and for transport of mTOR to lysosomes. (mTORC1 = mechanistic target of rapamycin complex-1; mTOR = mechanistic target of rapamycin)

  2. ORP5/8 regulate Ca(2+) signaling at specific membrane contact sites foci.

  3. ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM.

  4. mammalian ORP5 and ORP8 proteins localize to ER-mitochondrial MCS, in addition to ER-PM contact sites.

  5. Results show that OSBPL5 and CALU were expressed at higher levels in the lung tissues of metastasis-positive cases than that in the metastasis-negative cases suggesting they can promote invasiveness of lung cancer cells.

  6. ORP5 and ORP8 could mediate PI4P/phosphatidylserine (PS) countertransport between the endoplasmic reticulum (ER) and the plasma membrane (PM), thus delivering PI4P to the ER-localized PI4P phosphatase Sac1 for degradation and PS from the ER to the PM.

  7. ORP5 may cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes.

  8. OBPH1/Obph1 gene is imprinted, with preferential expression from the maternal allele in human and mouse.

  9. Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells.

  10. OSBPL5 is relatd to invasion and poor prognosis in pancreatic cancer.

Mouse (Murine) Oxysterol Binding Protein-Like 5 (OSBPL5) interaction partners

  1. OBPH1/Obph1 gene is imprinted, with preferential expression from the maternal allele in human and mouse.

  2. OSBP regulates hepatic TG metabolism and suggest the involvement of OSBP in the insulin signaling pathways that control hepatic lipogenesis.

Oxysterol Binding Protein-Like 5 (OSBPL5) Protein Profile

Protein Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with OSBPL5

  • oxysterol binding protein-like 5 (Osbpl5)
  • oxysterol binding protein like 5 (OSBPL5)
  • oxysterol binding protein like 5 (osbpl5)
  • 1110006M06Rik protein
  • AI462538 protein
  • MGC109308 protein
  • Obph1 protein
  • ORP5 protein
  • Osbp2 protein
  • OSBPL5 protein

Protein level used designations for OSBPL5

oxysterol binding protein-like 5 , oxysterol-binding protein-related protein 5-like , ORP-5 , OSBP-related protein 5 , oxysterol-binding protein homolog 1 , oxysterol-binding protein homologue 1 , oxysterol-binding protein-related protein 5 , oxysterol binding protein 2 , oxysterol binding protein homolog 1 , oxysterol-binding protein-like protein 5

GENE ID SPECIES
361686 Rattus norvegicus
483671 Canis lupus familiaris
532690 Bos taurus
770816 Gallus gallus
100431919 Pongo abelii
100466215 Ailuropoda melanoleuca
100515995 Sus scrofa
100539452 Meleagris gallopavo
100564429 Anolis carolinensis
114879 Homo sapiens
79196 Mus musculus
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