anti-P21-Activated Kinase 6 (PAK6) Antibodies

Human P21-Activated Kinase 6 (PAK6) interaction partners

1. inhibition of PAK6 leads to reduction in cell proliferation, migration and invasion of cigarette smoke treated non-small cell lung cancer cells

2. Study shows that high PAK6 expression is associated with poor prognosis and increased chemoresistance to 5-FU/oxaliplatin chemotherapy of gastric tumor.

3. RhoD recruits Pak6 to the plasma membrane to antagonize RhoC signaling during cell contraction and blebbing

4. PAK6 localization to cell-cell adhesions is Cdc42-dependent

5. p21-activated kinase 6 (PAK6) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2), a kinase involved in Parkinson's disease

6. PAK6 is directly targeted by miR-328. miR-328 inhibits cell growth and promotes cell apoptosis in prostate cancer cells.

7. negative correlation between PAK6 and EZH2 expression was observed in hepatoma tissues from HCC patients. These data identified the tumor suppressive role and potential underlying mechanism of PAK6 in hepatocarcinogenesis

8. the results of the present study suggested that miR-429 inhibits the migration and invasion of colon cancer cells, partly at least, by mediating the expression of PAK6, as well as the activity of cofilin signaling

9. we report that in colon cancer PAK6 promotes tumor progression and chemoresistance both in vitro and in vivo

10. PAK6 is specifically required for carcinoma cell-cell dissociation downstream of hepatocyte growth factor (HGF) for both DU145 prostate cancer and HT29 colon cancer cells.

11. PAK5 plays an essential role in the initiation and progression of hepatocellular carcinoma.

12. These results demonstrate that androgen-stimulated PAK6 activation is mediated through a direct interaction between AR and PAK6 and PAK6 activation promotes prostate cancer cells motility and invasion.

13. PAK6 is overexpressed in hepatocellular carcinoma, compared with the adjacent noncancerous liver tissues, and is associated with poor prognosis.

14. PAK6 phosphorylates Mdm2 on Thr-158 and Ser-186, which is critical for AR ubiquitin-mediated degradation.

15. Hypermethylation of PAK6 gene is associated with adenocarcinoma.

16. Results indicate that all of the 3 prostate cancer specimens showed positive staining in the stroma, suggesting that PAK6 may participate in the stroma-cancer cell interaction in prostate cancer.

17. The activation of PAK6 by both p38 MAP kinase and MKK6 suggests that PAK6 plays a role in the cellular response to stress-related signals.

18. PAK5 is a potent regulator of Raf-1 activity and may control Raf-1 dependent signaling at mitochondria

19. PAK6 was weakly expressed in normal prostate epithelium. Its expression was increased in primary and metastatic prostate cancer, and was further increased in tumors that relapsed after androgen deprivation therapy.

Mouse (Murine) P21-Activated Kinase 6 (PAK6) interaction partners

1. p21-activated kinase 6 (PAK6) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2), a kinase involved in Parkinson's disease

2. data suggest that PAK-6 p21-activated kinase plays a role in weight gain unrelated to exercise and caloric intake

3. functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice

4. Our results indicate that Pak5 and Pak6 together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory.