This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants.
Gene names and symbols associated with P21-Activated Kinase 6 Proteins (PAK6)
p21 (RAC1) activated kinase 6 (PAK6) antibody
p21 protein (Cdc42/Rac)-activated kinase 6 (Pak6) antibody
p21 (RAC1) activated kinase 6 (Pak6) antibody
p21 protein (Cdc42/Rac)-activated kinase 6b (pak6b) antibody
p21 protein (Cdc42/Rac)-activated kinase 6 (PAK6) antibody
Protein level used designations for P21-Activated Kinase 6 Proteins (PAK6)