anti-PDS5, Regulator of Cohesion Maintenance, Homolog B (S. Cerevisiae) (PDS5B) Antibodies

PDS5B encodes a protein that interacts with the conserved protein complex termed cohesion. Additionally we are shipping PDS5B Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDS5B 23047 Q9NTI5
PDS5B 304218  
PDS5B 100710 Q4VA53
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Top anti-PDS5B Antibodies at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PDS5B Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 721_B cell lysate 100 μL 2 to 3 Days
$289.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of PDS5B using COLO205 whole cell lysates 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB Western Blot at 1:2000 dilution Lane 1: 293T/17 whole cell lysate Lane 2: DU145 whole cell lysate Lane 3: LNCaP whole cell lysate Lane 4: Raji whole cell lysate Lane 5: U-2OS whole cell lysate Lane 6: Hela whole cell lysate Lysates/proteins at 20 ug per lane. 200 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL 11 to 13 Days
$335.04
Details
Human Rabbit Un-conjugated IF, IHC, IHC (p), IP, WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μL 11 to 14 Days
$595.83
Details
Human Mouse Un-conjugated DB   50 μg 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunofluorescent staining of human cell line A-431 with PDS5B polyclonal antibody  at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli. Immunohistochemical staining of human cerebral cortex with PDS5B polyclonal antibody  at 1:200-1:500 dilution. 100 μL 11 to 12 Days
$577.33
Details
Human Rabbit Un-conjugated IF, IHC (p) Immunofluorescent staining of human cell line A-431 with PDS5B polyclonal antibody  at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli. Immunohistochemical staining of human kidney with PDS5B polyclonal antibody  shows strong nuclear positivity in cells in tubules and cells in glomeruli. 100 μL 11 to 12 Days
$577.33
Details
Human Mouse Un-conjugated DB, WB   100 μg 11 to 16 Days
$608.14
Details

Top referenced anti-PDS5B Antibodies

  1. Human Polyclonal PDS5B Primary Antibody for ICC, IF - ABIN152174 : Brough, Bajrami, Vatcheva, Natrajan, Reis-Filho, Lord, Ashworth: APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer. in The EMBO journal 2012 (PubMed)
    Show all 2 Pubmed References

More Antibodies against PDS5B Interaction Partners

Human PDS5, Regulator of Cohesion Maintenance, Homolog B (S. Cerevisiae) (PDS5B) interaction partners

  1. Pds5B forms an integral part of the cohesin ring by contacting all other cohesin subunits, a property that may reflect the complex role of Pds5 proteins in controlling cohesin-DNA interactions.

  2. MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling.

  3. The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B.

  4. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved.

  5. The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL.

  6. Pds5 stabilizes a transient, open state of cohesin to promote its release from chromosomes.

  7. APRIN expression levels correlate with a better survival in ovarian cancer patients and that APRIN depletion sensitizes cells to the PARP inhibitor Olaparib in xenografted zebrafish.

  8. Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability.

  9. Here, the authors use proteomic profiling to identify APRIN (PDS5B), a cohesion-associated protein, as a BRCA2-associated protein.

  10. Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma.

  11. AS3 is a mediator of the proliferative arrest in the normal rat prostate in situ and that its expression is androgen-induced (AS3 protein)

  12. The results of this study indicate that the aberrant expression of AS3 may be involved in the tumorigenesis of esophagus and is responsible for the male predominance of ESCC.

  13. identified a functional missense mutation (R1292Q) in the PDS5B DNA-binding domain in a family with Cornelia de Lange syndrome, in which affected individuals also develop megacolon

  14. Pard-3 and AS3 genes are mutationally inactivated in prostate cancer cells.

Mouse (Murine) PDS5, Regulator of Cohesion Maintenance, Homolog B (S. Cerevisiae) (PDS5B) interaction partners

  1. findings demonstrate that Her2+/+ mice, similar to Pds5b-/- mice, are embryonic lethal and confirm the necessity for Pds5b in embryonic development

  2. reduced accumulation of Aurora B at the inner centromere region in cells lacking Pds5B impairs its error correction function, promoting chromosome mis-segregation and aneuploidy

  3. demonstrates that overexpression of APRIN inhibits differentiation and proliferation and promotes apoptosis in P19 embryonal carcinoma cells.

  4. A paper used gene targeting in mice to demonstrate the function of PDS5B in embryonic development.

  5. APRIN, in addition to its Pds5 similarity, has the features and localization of a hormone-induced chromatin regulator.

  6. While Pds5A(-/-) and Pds5B(-/-) mice die at birth, embryos harboring 3 mutant Pds5 alleles die between E11.5 and E12.5 most likely of heart failure, indicating that total Pds5 gene dosage is critical for normal development.

PDS5B Antigen Profile

Protein Summary

This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene.

Gene names and symbols associated with PDS5B

  • PDS5 cohesin associated factor B (PDS5B) antibody
  • PDS5 cohesin associated factor B (Pds5b) antibody
  • PDS5 cohesin associated factor B (pds5b) antibody
  • PDS5 cohesin associated factor B L homeolog (pds5b.L) antibody
  • AI646570 antibody
  • aprin antibody
  • as3 antibody
  • AW212954 antibody
  • CG008 antibody
  • mKIAA0979 antibody
  • pds5b antibody

Protein level used designations for PDS5B

androgen induced inhibitor of proliferation , androgen-induced proliferation inhibitor , androgen-induced prostate proliferative shutoff-associated protein AS3 , androgen-induced shutoff 3 , sister chromatid cohesion protein PDS5 homolog B , androgen-induced prostate proliferative shutoff associated protein , PDS5, regulator of cohesion maintenance, homolog B , androgen-induced prostate proliferative shutoff associated protein AS3 , androgen-induced proliferation inhibitor A , sister chromatid cohesion protein PDS5 homolog B-A , sister chromatid cohesion protein Pds5B

GENE ID SPECIES
23047 Homo sapiens
304218 Rattus norvegicus
418910 Gallus gallus
100135353 Xenopus (Silurana) tropicalis
100710 Mus musculus
734718 Xenopus laevis
486014 Canis lupus familiaris
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