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PDLIM5 encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. Additionally we are shipping PDZ and LIM Domain 5 Antibodies (70) and PDZ and LIM Domain 5 Kits (2) and many more products for this protein.
Showing 4 out of 4 products:
this study shows functional importance of PDLIM5 for proper kAE1 membrane residency, as a crucial linker between kidneyAE1 and actin cytoskeleton-associated proteins in polarized cells
PDLIM5 promotes papillary thyroid carcinoma via activation of the Ras-ERK (show EPHB2 Proteins) pathway.
PDLIM5 was strongly up-regulated during cardiomyogenesis and novel stage-specific isoforms were detected for PDLIM5
Findings provide evidence of shared genetic variants in PDLIM5 gene influencing alcohol dependence, type 2 diabetes, and hypertension.
The study provides evidence of several genetic variants within the PDLIM5 gene and interactions between PDLIM5 and steroid use influencing cancer.
It can be deduced that the nonsynonymous rs7690296 polymorphism of PDLIM5 could play an important role in the pathophysiology of both bipolar disorder and schizophrenia.
PDLIM5 (rs17021918,T), SLC22A3 (show OCT3 Proteins) (rs9364554,C) and NKX3-1 (show NKX3-1 Proteins) (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men.
The significant difference in expression of PDLIM5 mRNA in the peripheral blood leukocytes of treatment-naive bipolar (BPD) patients versus that of healthy control subjects suggests that it may be a good biological marker for BPD.
LIM domains have a novel molecular function: the regulation of PKC activities in a PKC isoform-specific manner.
Altered expression of LIM was found in brains and lymphoblastoid cells from patients with bipolar disorder.
These results reveal a E2F1 (show E2F1 Proteins)/miR-17-92/ENH1/Id1 (show ID1 Proteins) regulatory axis during myogenesis.
Collectively, our results suggest that ENH1 plays an important role in the activation of myogenesis through the repression of Id2 activity.
Cypher (show LDB3 Proteins) and ENH redundantly play an essential role in sustaining Z-line structure from the earliest stages of cardiac function, and are redundantly required to maintain normal embryonic heart function and embryonic viability.
PDLIM5 is involved in psychiatric disorders, including mood disorders
ENH1 with multiple protein-protein interaction modules is essential for differentiation of striated (show NSDHL Proteins) muscles, whereas ectopic expression of LIM domain-less ENH disrupts normal muscle differentiation.
coordinated and stepwise splicing transitions result in the production of specific ENH transcripts in mature striated (show NSDHL Proteins) muscles.
Deletion of ENH leads to destabilization of this protein complex and dilated cardiomyopathy in mice.
Antagonistic splice variants of enigma (show PDLIM7 Proteins) may play a central role in the adaptive changes of the link between mechanical stress-sensing and signalling occurring during embryonic development and/or heart hypertrophy.
Western blot studies of muscle tissues revealed that ENH4 is present only in skeletal muscle and there is a specific distribution of ENH members between skeletal and cardiac muscles, which is different in human and mouse.
These results identify Enigma as a novel APS-binding protein and suggest that the APS/Enigma complex plays a critical role in actin cytoskeleton organisation.
findings show the temporal & spatial expression patterns of the 3 Enigma (show PDLIM7 Proteins) family members & their PDZ & LIM domain encoding splice forms during embryogenesis
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants.
PDZ and LIM domain protein 5
, enigma homolog
, enigma-like LIM domain protein
, enigma-like PDZ and LIM domains protein
, PDZ and LIM domain 5
, PDZ and LIM domain protein 5-like