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The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. Additionally we are shipping and and many more products for this protein.
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findings implicate alternate transcription initiation as a mechanism to increase the functional diversity of NPC components, such as POM121
The conserved features of the NLSs of ScHeh1, ScHeh2, and RnPom121 and the effective sorting of Heh2-derived reporters in human cells suggest that active import is conserved but confined to a small subset of INM proteins.
Data suggest that the nuclear migration of Pom121 and its subsequent interaction with inner nuclear membrane proteins are required to initiate interphase nuclear pore complex assembly.
The the N terminus of Pom121 directly binds the beta-propeller regions of Nup155 and Nup160.
The nuclear localization signal sites of Pom121 affect its function in nuclear pore complex assembly both by influencing nucleoporin interactions and pore membrane structure.
RNAi experiments showed that efficient depletion of both Pom121 proteins significantly reduces assembled nuclear pore complexes on nuclear envelope.
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and multiple pseudogenes have been identified.
POM121 membrane glycoprotein
, nuclear envelope pore membrane protein POM 121
, nuclear envelope pore membrane protein POM 121A
, nuclear pore membrane protein 121 kDa
, nucleoporin Nup121
, pore membrane protein of 121 kDa
, nuclear pore membrane glycoprotein 121 kD
, nuclear pore membrane protein 121
, POM121 membrane glycoprotein C