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The protein encoded by PRDM7 is a transcription factor of the PR-domain protein family.
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These studies indicate that after a single serine to tyrosine mutation at residue 357 (S357Y), PRDM7 regains the substrate specificities and catalytic activities similar to its evolutionary predecessor, including the ability to efficiently methylate H3K36.
Evolutionary analysis suggests that human PRDM7 and PRDM9 (show PRDM9 Antibodies) genes, a pair of close paralogs corresponding to a single mouse gene Prdm9 (show PRDM9 Antibodies), were generated by a recent gene duplication event after the divergence of the ancestors of human and mouse.
The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
PR domain zinc finger protein 7
, PR-domain family protein 4
, probable histone-lysine N-methyltransferase PRDM7
, PR domain containing 7
, PR domain containing 9
, PR domain containing 7-like
, LOW QUALITY PROTEIN: probable histone-lysine N-methyltransferase PRDM7