PRKC, Apoptosis, WT1, Regulator Proteins (PAWR)

Human PRKC, Apoptosis, WT1, Regulator (PAWR) interaction partners

1. we determined that increased miR-17-3P level plays crucial role in CRC (show CALR Proteins) cells survival by targeting Par4, contributing to colorectal carcinogenesis.

2. PAR4 is the target of mir (show MLXIP Proteins)-107 in colorectal cancer cells.

3. we confirmed that the RASSF2-PAR-4 axis was mainly responsible for miR-7 functions in CAFs using bioinformatics methods. Overexpression of miR-7 in CAFs led to down-regulation of RASSF2, which dramatically decreased the secretion of PAR-4 from CAFs and then enhanced the proliferation and migration of the co-cultured cancer cells.

4. we investigated in the present study the mechanisms regulating the accumulation of a 25kDa (show SFRS9 Proteins) cleaved-Par-4 (cl-Par-4) fragment in ovarian and endometrial cancer cell lines

5. Authors demonstrate that TRIM21 (show TRIM21 Proteins) expression predicts survival in pancreatic cancer patients. This work highlights a novel mechanism of Par-4 regulation, and identifies a novel prognostic marker and potential therapeutic target for pancreatic cancer.

6. Data suggest that PAR4 and P2Y12 (show P2RY12 Proteins) heterodimer internalization/endocytosis is required for beta-arrestin-2 (show ARRB2 Proteins) recruitment to endosomes and up-regulation of Akt (show AKT1 Proteins) signaling; activation of PAR4 but not of P2Y12 (show P2RY12 Proteins) drives internalization of the PAR4-P2Y12 (show P2RY12 Proteins) heterodimer. (PAR4 = protease-activated receptor 4 (show F2RL3 Proteins); P2Y12 (show P2RY12 Proteins) = purinergic receptor P2Y (show P2RY1 Proteins), G-protein coupled, 12 protein; Akt (show AKT1 Proteins) = proto-oncogene (show RAB1A Proteins) protein c-akt (show AKT1 Proteins))

7. In this review, we will focus on the therapeutic perspective of Par-4 with a special reference to its (Par-4) virgin prospect of devastating metastasis control.

8. in vitro and in vivo upregulation of Par-4 expression is indispensable for the trafficking of GRP78 (show HSPA5 Proteins) to the cell membrane and subsequent apoptosis of cancer cell

9. Prostate apoptosis response 4 (PAR4) expression modulates WNT (show WNT2 Proteins) signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity.

10. Decreased PAR4 expression in breast cancer is associated with shorter survival. PAR4 suppresses growth and invasiveness of breast cancer cells.

Mouse (Murine) PRKC, Apoptosis, WT1, Regulator (PAWR) interaction partners

1. Induced by endoplasmic reticulum stress Par-4 (show F2RL3 Proteins) acts as an important defense mechanism against mycobacterial infection and regulates cancer.

2. Findings reveal a novel role for Par-4 (show F2RL3 Proteins)/NF-kappaB (show NFKB1 Proteins) in islet beta cell apoptosis and type 2 diabetes.

3. Par4 (show F2RL3 Proteins), CEBPB (show CEBPB Proteins) and FAK (show PTK2 Proteins) form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT (show ITK Proteins) and self-renewal

4. a novel mechanism of apoptosis induction by PAR-4 (show F2RL3 Proteins)/ceramide-enriched exosomes, which may critically contribute to Alzheimer disease.

5. extracellular Par-4 (show F2RL3 Proteins)/SAC (show ADCY10 Proteins) is systemically functional in inhibition of tumor growth and metastasis progression.

6. loss of PAR4 (show F2RL3 Proteins) leads to a reduction in the ability of tumour necrosis factor-alpha (show TNF Proteins) to induce apoptosis by increased activation of NF-kappaB (show NFKB1 Proteins)

7. Antisense knockdown of PAR-4 (show F2RL3 Proteins) or inhibition of ceramide biosynthesis reduced stem cell apoptosis; PAR-4 (show F2RL3 Proteins) overexpression and treatment with ceramide analogs elevated apoptosis.

8. AATF (show AATF Proteins) is an endogenous antagonist of Par-4 (show F2RL3 Proteins) activity and an effective inhibitor of aberrant amyloid beta 1-42 production and secretion under apoptotic conditions.

9. Par-4 (show F2RL3 Proteins) is directly involved in regulating choline uptake by interacting with CHT1 (show ChT Proteins) and by reducing its incorporation on the cell surface

10. the mechanism for Ras-mediated down-regulation of Par-4 (show F2RL3 Proteins) is by promoter methylation