PTEN Induced Putative Kinase 1 (PINK1) ELISA Kits

PINK1 encodes a serine/threonine protein kinase that localizes to mitochondria. Additionally we are shipping PINK1 Antibodies (278) and PINK1 Proteins (11) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PINK1 65018 Q9BXM7
PINK1 68943 Q99MQ3
Anti-Rat PINK1 PINK1 298575  
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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human < 0.13 ng/mL 0.312 ng/mL - 20 ng/mL   96 Tests 11 to 18 Days
  96 Tests 15 to 18 Days

More ELISA Kits for PINK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Consumption of grape skin extract (GSE) resulted in rescue of mitochondrial morphological defects, improvement of indirect flight muscle function and health-span, and prolonged lifespan of the PINK1 mutant flies.

  2. Pink1 and parkin are not essential for bulk basal mitophagy in Drosophila

  3. Deficiency of PINK1 impairs age-dependent mitophagy in Drosophila.

  4. PINK1 mediates the phosphorylation of MCAD, a mitochondrial matrix protein critical to fatty acid metabolism.

  5. reduced locomotor activity and longer day sleep in PINK1 mutants and after decreasing the PINK1 level in neurons seem to be correlated with a decrease in mitochondria number during the day

  6. Expression of MIC60 restores crista structure and ATP levels of PINK1-null flies and remarkably rescues their behavioral defects and dopaminergic neurodegeneration.

  7. This study found learning and memory abnormalities in PINK1 mutant genotypes in Drosophila.

  8. Drosophila CHIP protects against mitochondrial dysfunction by acting downstream of Pink1 in parallel with Parkin

  9. Maintenance of tissue homeostasis upon reduction of Pink1 or Parkin appears to result from reduction of age- and stress-induced intestinal stem cell proliferation, in part, through induction of ISC senescence.

  10. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  11. autophosphorylation of PINK1 is essential for the mitochondrial translocation of Parkin and for subsequent phosphorylation and activation of Parkin.

  12. A pink1 genomic knock-in allele was generated to monitor the dynamic expression pattern of PINK1. The spatiotemporal expression pattern of PINK1 correlates with the cell-type specific mitochondrial clearance or persistence. PINK1 and PARKIN function epistatically to mediate timely specific mitophagy during Drosophila midgut metamorphosis.

  13. Our data indicate that PINK1 and Parkin play an important role in FUS-induced neurodegeneration. This study has uncovered a previously unknown link between FUS proteinopathy and PINK1/Parkin genes, providing new insights into the pathogenesis of FUS proteinopathy.

  14. we show that overexpression of Drosophila Clu complements PINK1, but not parkin, mutant muscles. Thus, Clu is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP for Marf degradation to promote damaged mitochondrial clearance.

  15. In addition, a PINK1 mutant, which induced mitochondrial enlargement and had been considered as a Drosophila model of Parkinson's disease (PD), caused fly muscle defects, and the loss of vimar could rescue these defects. Furthermore, we found that the mammalian homolog of Vimar, RAP1GDS1, played a similar role in regulating mitochondrial morphology, suggesting a functional conservation of this GEF member.

  16. Buffy has a role enhancing the loss of parkin and suppressing the loss of Pink1 phenotypes in Drosophila

  17. PINK1-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  18. Clu directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.

  19. Human Mask homolog ANKHD1 may serve as a potential therapeutic target for treating Parkinson disease caused by pink1/parkin mutations.

  20. PINK1B9 mutation in Drosophila melanogaster creates a phenotype that is a model for Parkinson's disease

Zebrafish PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Pink1-depleted zebrafish are the first vertebrate model of PINK1 deficiency with loss of dopaminergic neurons.

  2. Our findings suggest that a lack of pink1 in zebrafish alters many vital and critical pathways in addition to the HIF signaling pathway.

  3. Distinct groups of dopaminergic neurons are sensitive to targeted loss of Pink1 factor in a morphant fish model of toxin-induced Parkinson's disease.

  4. Morpholino-mediated loss of pink1 function in zebrafish profoundly affects the development of dopaminergic neurons in the ventral diencephalon and affects behaviour of the zebrafish larvae, namely their response to tactile stimuli and locomotor behavior.

Human PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Mitochondrial membrane potential loss-dependent PINK1 import arrest does not result solely from Tim23 inactivation but also through an actively regulated "tug of war" between Tom7 and OMA1.

  2. This study demonstrated that reveal a novel function of PINK1 in dopamine homeostasis.

  3. Mechanistically, parkin/PINK1 catalyze a rapid burst of Mfn2 phosphoubiquitination to trigger p97-dependent disassembly of Mfn2 complexes from the outer mitochondrial membrane, dissociating mitochondria from the endoplasmic reticulum.

  4. we use two distinct mitophagy reporter systems to reveal tonic suppression by USP30, of a PINK1-dependent component of basal mitophagy in cells lacking detectable Parkin.

  5. This article reviews and analyzes functional features emerging from recent crystallographic, nuclear magnetic resonance (NMR) and mass spectrometry studies of PINK1. [review]

  6. PINK1 plays a protective role in clearance of damaged mitochondrial and alleviating cell senescence under oxidative stress, whose mechanism is associated with regulating mitophagy in nucleus pulposus cells

  7. A PINK1-mediated mitophagy pathway may decide the fate of tumors-to be benign or malignant

  8. Study showed that homozygous PINK1 p.K520RfsX3 mutation is genetic cause in a consanguineous Chinese family with early-onset Parkinson's disease in a Chinese family.

  9. data show how autoinhibition in parkin is resolved, and suggest a mechanism for how parkin ubiquitinates its substrates via an untethered RING2 domain; these findings open new avenues for the design of parkin activators for clinical use

  10. These results identify a novel role of PINK1 modulating the levels of LRRK2 in Parkinson's disease fibroblasts and neurons.

  11. Knockdown of PINK1 suppressed the proliferation, migration, invasion, and induced apoptosis and mitochondrial dysfunction of lung cancer cells.

  12. these findings suggest that CHIP plays a role in negative regulation of PINK1 stability and may suppress PINK1's cytoprotective effect during staurosporine-induced mammalian cell death.

  13. Results describe a novel pathogenic mechanism in recessive Parkinson's disease, where PINK1 deficiency may increase neuron death via exacerbation of inflammatory stimuli-induced nitric oxide production and abnormal innate immune responses in glia cells.

  14. The results demonstrate that Nix can serve as an alternative mediator of mitophagy to maintain mitochondrial turnover, identifying Nix as a promising target for neuroprotective treatment in PINK1/Parkin-related Parkinson's disease.

  15. Studies indicate a functional PTEN-induced putative kinase 1)(PINK1)/E3 ubiquitin protein ligase (parkin) mitophagy pathway in neurons [Review].

  16. PINK1 detection could help stratify patients who may have poor response to chemotherapy and guide the individual treatment.

  17. A mitochondrial protein PINK1 acts as a mitochondrial gatekeeper able to sense the presence of healthy or damaged mitochondria. (Review)

  18. mitochondrial dysfunction activates the PINK1/Parkin signaling and mitophagy in renal tubular epithelial cells under albumin overload condition.

  19. High Pink1 Expression is Associated with Cancer Progression and Chemo-Resistance in Esophageal Squamous Cell Carcinoma.

  20. Hsp70participated in PINK1-mediated mitophagy by stabilizing PINK1.

Mouse (Murine) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. that the impaired dopamine release is most likely because of mitochondrial dysfunction and lower ATP production

  2. data from this work reveal that PINK1 possesses the protective effect via induction of autophagy and resistance of apoptosis under cisplatin stimulus in sensory hair cells and spiral ganglion neurons, implying that PINK1 might serve as an important regulator of cisplatin-elicited ototoxicity.

  3. PINK1 is detectable at basal levels and that basal mammalian mitophagy occurs independently of PINK1.

  4. Faulty mitophagy in dystrophic hearts due to defects in the PINK1/PARKIN signaling pathway.

  5. results support a role for PINK1- and parkin-mediated mitophagy in restraining innate immunity

  6. these findings suggest that CHIP plays a role in negative regulation of PINK1 stability and may suppress PINK1's cytoprotective effect during staurosporine-induced mammalian cell death.

  7. The data supports an indispensable role for Mule in cardiac homeostasis through the regulation of mitochondrial function via maintenance of Pgc-1alpha and Pink1 expression and persistent negative regulation of c-Myc.

  8. these data suggest that alleviation of the sustained mitochondrial dysfunction and oxidative stress through co-modulation of NRF2 and PINK1 may be in charge of restoration of the cognitive impairments in a mouse model of high-LET carbon ion irradiation

  9. This paper's findings delineate a mechanism by which PINK1 regulates mitochondrial Ca(2+) level through LETM1 and suggest a model by which PINK1 loss leads to deficient phosphorylation of LETM1 and impaired mitochondrial Ca(2+) transport.

  10. PINK1 and PARK2 suppress pancreatic tumorigenesis through control of mitochondrial iron-mediated immunometabolism

  11. This study demonstrated that in the Pink1-/- mouse showed disorder of vocalization and sensorimotor function.

  12. reveal a direct molecular link between nitrosative stress, S-nitrosylated PINK1 formation, and mitophagic dysfunction that contributes to the pathogenesis of Parkinson's disease

  13. In mitochondria from Pink1(-/-) mice, there was a decrease in free chloride and in free supercomplexes in cultured neurons.

  14. These findings provide evidence for a novel mechanism underlying the protective effects of PINK1 against alpha-syn-induced neurodegeneration and highlight a novel therapeutic target for Parkinson's disease treatment.

  15. The results of this study identify PINK1 deficiency as an early modulator of innate immunity in neurons, which precedes late stages of neuroinflammation during alpha-synuclein spreading.

  16. The expression of PINK1 and Parkin were elevated in white adipose tissue in obese mice.

  17. LncRNA NEAT1 promoted the MPTP-induced autophagy in PD through stabilization of PINK1 protein.

  18. Loss of Atad3a caused accumulation of Pink1 and activated mitophagy.

  19. PTEN-induced putative kinase 1 interacts with and phosphorylates serines 322 and 613 of PARIS to control its ubiquitination and clearance by parkin. PINK1 phosphorylation of PARIS alleviates PARIS toxicity, as well as repression of PGC-1alpha promoter activity.

  20. Findings highlight a novel mechanism by which PINK1-dependent signalling promotes the rescue of amyloid pathology and amyloid-beta-mediated mitochondrial and synaptic dysfunctions in a transgenic mouse Alzheimer's disease model.

PINK1 Antigen Profile

Antigen Summary

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Gene names and symbols associated with PINK1

  • PTEN-induced putative kinase 1 (Pink1) antibody
  • PTEN induced putative kinase 1 (PINK1) antibody
  • PTEN induced putative kinase 1 (pink1) antibody
  • PTEN induced putative kinase 1 (Pink1) antibody
  • 1190006F07Rik antibody
  • AU042772 antibody
  • AW557854 antibody
  • BEST:GH23468 antibody
  • BRPK antibody
  • CG4523 antibody
  • Dmel\\CG4523 antibody
  • dPink1 antibody
  • mFLJ00387 antibody
  • PARK6 antibody
  • PINK antibody
  • pink1 antibody
  • wu:fc39e12 antibody
  • zgc:101729 antibody

Protein level used designations for PINK1

CG4523-PA , CG4523-PB , CG4523-PC , CG4523-PD , CG4523-PE , CG4523-PF , CG4523-PG , CG4523-PH , PTEN induced putative kinase 1 , PTEN-Induced kinase 1 , Pink1-PA , Pink1-PB , Pink1-PC , Pink1-PD , Pink1-PE , Pink1-PF , Pink1-PG , Pink1-PH , PTEN-induced putative kinase 1 , serine/threonine-protein kinase PINK1, mitochondrial , serine/threonine-protein kinase PINK1, mitochondrial-like , PTEN-induced putative kinase protein 1 , protein kinase BRPK

31607 Drosophila melanogaster
425370 Gallus gallus
494085 Danio rerio
510683 Bos taurus
706037 Macaca mulatta
749028 Pan troglodytes
100027082 Monodelphis domestica
100412264 Callithrix jacchus
100443445 Pongo abelii
100465867 Ailuropoda melanoleuca
65018 Homo sapiens
68943 Mus musculus
298575 Rattus norvegicus
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