PTEN Induced Putative Kinase 1 (PINK1) ELISA Kits

PINK1 encodes a serine/threonine protein kinase that localizes to mitochondria. Additionally we are shipping PINK1 Antibodies (261) and PINK1 Proteins (13) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PINK1 65018 Q9BXM7
PINK1 68943 Q99MQ3
Anti-Rat PINK1 PINK1 298575  
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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human < 0.13 ng/mL 0.312 ng/mL - 20 ng/mL   96 Tests Log in to see 11 to 18 Days
  96 Tests Log in to see 15 to 18 Days

More ELISA Kits for PINK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. This study found learning and memory abnormalities in PINK1 mutant genotypes in Drosophila.

  2. Drosophila CHIP protects against mitochondrial dysfunction by acting downstream of Pink1 in parallel with Parkin

  3. Maintenance of tissue homeostasis upon reduction of Pink1 or Parkin appears to result from reduction of age- and stress-induced intestinal stem cell proliferation, in part, through induction of ISC senescence.

  4. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  5. autophosphorylation of PINK1 is essential for the mitochondrial translocation of Parkin and for subsequent phosphorylation and activation of Parkin.

  6. A pink1 genomic knock-in allele was generated to monitor the dynamic expression pattern of PINK1. The spatiotemporal expression pattern of PINK1 correlates with the cell-type specific mitochondrial clearance or persistence. PINK1 and PARKIN function epistatically to mediate timely specific mitophagy during Drosophila midgut metamorphosis.

  7. Our data indicate that PINK1 and Parkin play an important role in FUS-induced neurodegeneration. This study has uncovered a previously unknown link between FUS proteinopathy and PINK1/Parkin genes, providing new insights into the pathogenesis of FUS proteinopathy.

  8. we show that overexpression of Drosophila Clu complements PINK1, but not parkin, mutant muscles. Thus, Clu is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP for Marf degradation to promote damaged mitochondrial clearance.

  9. In addition, a PINK1 mutant, which induced mitochondrial enlargement and had been considered as a Drosophila model of Parkinson's disease (PD), caused fly muscle defects, and the loss of vimar could rescue these defects. Furthermore, we found that the mammalian homolog of Vimar, RAP1GDS1, played a similar role in regulating mitochondrial morphology, suggesting a functional conservation of this GEF member.

  10. Buffy has a role enhancing the loss of parkin and suppressing the loss of Pink1 phenotypes in Drosophila

  11. PINK1-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  12. Clu directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.

  13. Human Mask homolog ANKHD1 may serve as a potential therapeutic target for treating Parkinson disease caused by pink1/parkin mutations.

  14. PINK1B9 mutation in Drosophila melanogaster creates a phenotype that is a model for Parkinson's disease

  15. Various ways of stimulation of the ETC (genetic, pharmacologic and mechanical) (Figure 1) all improve a Pink1 fly model.

  16. These results indicate that the in vivo rescue is due to restoring CI activity rather than promoting mitophagy Our findings support the emerging view that PINK1 plays a role in regulating complex I activity separate from its role with Parkin in mitophagy

  17. MUL1 acts in parallel to the PINK1/parkin pathway on a shared target mitofusin to maintain mitochondrial integrity.

  18. PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila.

  19. PINK1 cooperates with Parkin to promote hnRNP-F/Glo ubiquitination and nRCC mRNA translation.

  20. results strongly circumscribe the possible mechanisms of PINK1 action in the mitochondrial life cycle

Zebrafish PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Pink1-depleted zebrafish are the first vertebrate model of PINK1 deficiency with loss of dopaminergic neurons.

  2. Our findings suggest that a lack of pink1 in zebrafish alters many vital and critical pathways in addition to the HIF signaling pathway.

  3. Distinct groups of dopaminergic neurons are sensitive to targeted loss of Pink1 factor in a morphant fish model of toxin-induced Parkinson's disease.

  4. Morpholino-mediated loss of pink1 function in zebrafish profoundly affects the development of dopaminergic neurons in the ventral diencephalon and affects behaviour of the zebrafish larvae, namely their response to tactile stimuli and locomotor behavior.

Human PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. These results identify a novel role of PINK1 modulating the levels of LRRK2 in Parkinson's disease fibroblasts and neurons.

  2. Knockdown of PINK1 suppressed the proliferation, migration, invasion, and induced apoptosis and mitochondrial dysfunction of lung cancer cells.

  3. these findings suggest that CHIP plays a role in negative regulation of PINK1 stability and may suppress PINK1's cytoprotective effect during staurosporine-induced mammalian cell death.

  4. Results describe a novel pathogenic mechanism in recessive Parkinson's disease, where PINK1 deficiency may increase neuron death via exacerbation of inflammatory stimuli-induced nitric oxide production and abnormal innate immune responses in glia cells.

  5. The results demonstrate that Nix can serve as an alternative mediator of mitophagy to maintain mitochondrial turnover, identifying Nix as a promising target for neuroprotective treatment in PINK1/Parkin-related Parkinson's disease.

  6. Studies indicate a functional PTEN-induced putative kinase 1)(PINK1)/E3 ubiquitin protein ligase (parkin) mitophagy pathway in neurons [Review].

  7. PINK1 detection could help stratify patients who may have poor response to chemotherapy and guide the individual treatment.

  8. A mitochondrial protein PINK1 acts as a mitochondrial gatekeeper able to sense the presence of healthy or damaged mitochondria. (Review)

  9. mitochondrial dysfunction activates the PINK1/Parkin signaling and mitophagy in renal tubular epithelial cells under albumin overload condition.

  10. High Pink1 Expression is Associated with Cancer Progression and Chemo-Resistance in Esophageal Squamous Cell Carcinoma.

  11. Hsp70participated in PINK1-mediated mitophagy by stabilizing PINK1.

  12. This study showed that the heterozygous Pink1 mutation carriers show subtle motor abnormalities when a detailed, specialized motor examination is applied and compared to mutation-negative matched control subjects.

  13. These findings provide evidence for a novel mechanism underlying the protective effects of PINK1 against alpha-syn-induced neurodegeneration and highlight a novel therapeutic target for Parkinson's disease treatment.

  14. Study confirmed that common variants in PARL and PINK1 were associated with leprosy. Furthermore, PARL and PINK1 could physically interact with each other and were involved in the highly connected network formed by reported leprosy susceptibility genes

  15. melatonin stimulates PINK1 expression via an MT2 /Akt/NF-kappaB pathway, and such stimulation is important for the prevention of neuronal cell apoptosis under high glucose conditions.

  16. The importance of parkin activation by the PINK1 phosphorylation.

  17. Target of PINK1 polyubiquitination is the mature form and is mediated by ubiquitination of a conserved lysine at position 137.

  18. that mutant PINK1 p.I368N can not be stabilized on the outer mitochondrial membrane upon mitochondrial stress and due to conformational changes in the active site does not exert kinase activity towards ubiquitin

  19. PINK1 mediates the complex balance between polyphyllin I-induced mitophagy and mitochondrial fission-mediated apoptosis in breast cancer cells.

  20. Here we review the evidence supporting PINK1/Parkin mitophagy in vivo and its causative role in neurodegeneration, and outline outstanding questions for future investigations.

PINK1 Antigen Profile

Antigen Summary

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Gene names and symbols associated with PINK1

  • PTEN-induced putative kinase 1 (Pink1) antibody
  • PTEN induced putative kinase 1 (PINK1) antibody
  • PTEN induced putative kinase 1 (pink1) antibody
  • PTEN induced putative kinase 1 (Pink1) antibody
  • 1190006F07Rik antibody
  • AU042772 antibody
  • AW557854 antibody
  • BEST:GH23468 antibody
  • BRPK antibody
  • CG4523 antibody
  • Dmel\\CG4523 antibody
  • dPink1 antibody
  • mFLJ00387 antibody
  • PARK6 antibody
  • PINK antibody
  • pink1 antibody
  • wu:fc39e12 antibody
  • zgc:101729 antibody

Protein level used designations for PINK1

CG4523-PA , CG4523-PB , CG4523-PC , CG4523-PD , CG4523-PE , CG4523-PF , CG4523-PG , CG4523-PH , PTEN induced putative kinase 1 , PTEN-Induced kinase 1 , Pink1-PA , Pink1-PB , Pink1-PC , Pink1-PD , Pink1-PE , Pink1-PF , Pink1-PG , Pink1-PH , PTEN-induced putative kinase 1 , serine/threonine-protein kinase PINK1, mitochondrial , serine/threonine-protein kinase PINK1, mitochondrial-like , PTEN-induced putative kinase protein 1 , protein kinase BRPK

31607 Drosophila melanogaster
425370 Gallus gallus
494085 Danio rerio
510683 Bos taurus
706037 Macaca mulatta
749028 Pan troglodytes
100027082 Monodelphis domestica
100412264 Callithrix jacchus
100443445 Pongo abelii
100465867 Ailuropoda melanoleuca
65018 Homo sapiens
68943 Mus musculus
298575 Rattus norvegicus
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