Paired Box 7 Proteins (PAX7)

Turkey Paired Box 7 (PAX7) interaction partners

1. These data suggested that expression of the myogenic regulatory transcription factors are dependent upon expression of glypican-1 (show GPC1 Proteins) and syndecan-4 (show SDC4 Proteins) during satellite cell proliferation and differentiation, and Pax7 expression is influenced by glypican-1 (show GPC1 Proteins).

Human Paired Box 7 (PAX7) interaction partners

1. miR (show MLXIP Proteins)-206 acts as a tumor suppressor in fusion-negative RMS at least partially through downregulation of PAX7.

2. PAX7 expression is a useful marker of skeletal muscle differentiation in rhabdomyosarcoma, particularly of the embryonal subtype, with specificity for rhabdomyosarcoma and Ewing sarcoma.

3. NTN1 (show NTN1 Proteins) rs9788972 is identified as a risk locus for nonsyndromic orofacial clefts susceptibility in a northern Chinese population; SNPs in PAX7 were not associated with any increased risk

4. Our results on Pax7 and MyoD protein expression suggest that proliferation and differentiation of skeletal muscle stem cells are affected in ALS patients, and the myogenic processes cannot overcome the denervation-induced wasting.

5. these results suggest that sarcoma metastasis can be partially controlled through Pax7/MyoD (show MYOD1 Proteins)-dependent activation of miR (show MLXIP Proteins)-182 and provide insight into the role that myogenic transcription factors have in sarcoma progression

6. RAGE (show AGER Proteins) upregulates myogenin (show MYOG Proteins) which upregulates MyoD (show MYOD1 Proteins) and downregulates PAX7, with consequent inhibition of proliferation and stimulation of differentiation.

7. Pax7 responds to NF-kappaB (show NFKB1 Proteins) by impairing the regenerative capacity of myogenic cells in the muscle microenvironment to drive muscle wasting in cancer.

8. High prevalence of 1p36 microdeletions in B-cell non-Hodgkin lymphomas is associated with PAX7 loss.

9. Our study replicated previous GWAS findings for markers in VAX1 (show VAX1 Proteins) in the Asian population, and identified rare variants in PAX7 and VAX1 (show VAX1 Proteins) that may contribute to the etiology of CL(P)

10. In addition, eight genes classified as 'second tier' hits in the original study (PAX7, THADA, COL8A1 (show COL8A1 Proteins)/FILIP1L, DCAF4L2, GADD45G (show GADD45G Proteins), NTN1 (show NTN1 Proteins), RBFOX3 (show RBFOX3 Proteins) and FOXE1 (show FOXE1 Proteins)) showed evidence of linkage and association in this replication sample.

Xenopus laevis Paired Box 7 (PAX7) interaction partners

1. Our results show that the expression of Pax6 (show PAX6 Proteins) and Pax7 is widely maintained in the adult brain of Xenopus

2. The Pax3 (show PAX3 Proteins) and Pax7 paralogs cooperate in neural and neural crest patterning using distinct molecular mechanisms, in Xenopus laevis embryos.

3. Results show that inhibition of pax7 does not prevent differentiation of satellite cells to myofibres, but it does prevent their maintenance as a stem cell population.

Cow (Bovine) Paired Box 7 (PAX7) interaction partners

1. four novel polymorphisms were identified in the Pax7 gene; the association analysis of genotypes in the single and combined SNP(s) revealed consistent effects on growth traits in NY cattle

Mouse (Murine) Paired Box 7 (PAX7) interaction partners

1. Barx2 (show BARX2 Proteins) and Pax7 regulate the canonical Wnt (show WNT2 Proteins) target gene Axin2 (show AXIN2 Proteins), which mediates critical feedback to terminate the transcriptional response to Wnt (show WNT2 Proteins) signals.

2. Stat3 (show STAT3 Proteins) regulates self-renewal of adult muscle satellite cells during injury-induced muscle regeneration through various partners, such as Pax7.

3. Lkb1 (show STK11 Proteins) activates the Notch (show NOTCH1 Proteins) signaling pathway, which subsequently increases Pax7 expression and promotes self-renewal and proliferation while inhibiting differentiation. Mechanistic studies reveal that Lkb1 (show STK11 Proteins) regulates Notch (show NOTCH1 Proteins) activation through AMPK (show PRKAA1 Proteins)-mTOR (show FRAP1 Proteins) pathway in myoblasts.

4. Pax7 binding induces dramatic, localized remodeling of chromatin characterized by the acquisition of histone marks associated with enhancer activity and induction of chromatin accessibility in both muscle precursors and lineage-committed myoblasts. Conversely, removal of Pax7 leads to rapid reversal of these features on a subset of enhancers.

5. the absence of functional Pax7 in differentiating embryonic stem cells modulates cell cycle facilitating their proliferation.

6. findings demonstrate a key role for the lingual epithelial signals in supporting the integrity of the lamina propria and muscular tissue during tongue development and that a Wnt (show WNT2 Proteins)/Notch (show NOTCH1 Proteins)/Pax7 genetic hierarchy is involved in this development.

7. results support the concept that lack of functional Pax7 promotes proliferation of differentiating ESCs (show NR2E3 Proteins) and for this reason more of them can turn into myogenic lineage.

8. the absence of functional Pax7 does not prevent the in vitro myogenic differentiation of embryonic stem cells.

9. These results underscore DNA demethylation as a key mechanism driving myogenesis and identify specific Pax7-mediated DNA demethylation signatures to acquire and maintain the muscle-cell identity.

10. we propose that Nedd4 functions as a novel Pax7 regulator, which activity is temporally and spatially controlled to modulate the Pax7 protein levels and therefore satellite cell fate.

Zebrafish Paired Box 7 (PAX7) interaction partners

1. Cells marked by pax7a only or by both pax7a and pax7b enter the wound rapidly and contribute to muscle wound repair, but each behaves differently.

2. Pax7 is required for adult skeletal muscle repair.

3. Pax7 identifies neural crest, chromatophore lineages and pigment stem cells during development.