anti-Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA) Antibodies

Human Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA) interaction partners

1. We propose that PILRA G78R protects individuals from Alzheimer's disease risk via reduced inhibitory signaling in microglia and reduced microglial infection during HSV-1 recurrence.

2. Data suggest that, although PILRA exhibits essentially the same recognition of different glycopeptides, slight modifications of linker sugar cause significant changes in a wide area of the binding interface, resulting in a reduction of binding affinity; analogs/fragments of gpb were used in these studies. (PILRA = paired immunoglobin like type 2 receptor alpha; gpb = envelope glycoprotein B, Herpes simplex virus type 1)

3. The interaction of NK cells with PILRalpha expressing targets lead to elevated IFNgamma secretion and cytotoxicity. In conclusion, PILRalpha is a novel NK activating ligand which binds and activates an unknown NK receptor expressed on a unique NK cell subset.

4. Transcriptome wide association study results identified two novel genes as statistically significantly associated with nonobstructive azoospermia susceptibility: PILRA and ZNF676.

5. PILRalpha exhibits large conformational change to recognize simultaneously both the sTn O-glycan and the compact peptide structure constrained by proline residues

6. These results contribute our knowledge of the biological functions of HBVDNAPTP1 and provide novel data to aid in the further analysis of the regulatory mechanism of this protein.

7. We demonstrated that three residues (Y2, R95, and W108) presented on the surface of PILRalpha form the sialic acid binding site equivalent to those in siglecs but are arranged in a unique linear mode.

8. The amino terminus of herpes simplex virus 1 gK is functionally and physically associated with the gB-PILRalpha protein complex and regulates membrane fusion of the viral envelope with cellular membranes during virus entry.

9. The authors show that the human ocular and highly neurovirulent HSV-1 strain McKrae enters substantially more efficiently into cells via the gB-specific human paired immunoglobulin-like type-2 receptor-alpha (hPILR-alpha).

10. Data show that PILRalpha/ligand interactions require conserved PILRalpha arginine (Arg)-133 (mouse) and Arg-126 (human).

11. These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha.

12. PILRalpha protein was successfully crystallized at 293 K using the sitting-drop vapour-diffusion method and the crystals diffracted to 1.3 A resolution.

13. The results demonstrate that cellular receptors for both gB and gD are required for HSV-1 infection and that PILRalpha plays an important role in HSV-1 infection as a coreceptor that associates with gB.

14. viral entry via PILRalpha appears to be conserved but that there is a PILRalpha preference among alphaherpesviruses

15. Insertional mutations of gB reduced cell fusion activity when PILRalpha was overexpressed much more than nectin-1.

Mouse (Murine) Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA) interaction partners

1. Data suggest that immune inhibitory receptor, PILRalpha, plays an important role in the prevention of obesity and liver fibrosis.

2. Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase.

3. negatively regulates inflammatory colitis by reducing the neutrophil and macrophage infiltration

4. demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilralpha is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation

5. Data indicate paired Ig-like type 2 receptor (PILR)alpha Pilra-/- mice develop enhanced autoimmune arthritis.

6. regulates neutrophil recruitment in inflammatory responses modulation of integrin activation

7. Data show that PILRalpha/ligand interactions require conserved PILRalpha arginine (Arg)-133 (mouse) and Arg-126 (human).

8. These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha.

9. abilities of HSV-1 to enter cells in a PILRalpha-dependent manner and to acquire specific carbohydrates on gB are therefore linked to an increase in viral replication and virulence

10. Domain V of paired Ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion.

11. Activation of PILRa or deletion of PILRb helps to control acute Staphylococcus aureus-mediated pneumonia and attenuate the inflammatory response.