anti-Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA) Antibodies

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. Additionally we are shipping PILRA Proteins (9) and PILRA Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PILRA 29992 Q9UKJ1
PILRA 231805 Q2YFS3
Anti-Rat PILRA PILRA 288568  
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Top anti-PILRA Antibodies at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PILRA Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Mouse Rabbit Un-conjugated IHC (p), ELISA Immunochemical staining of mouse PILRA in mouse intestine with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). 100 μL 14 to 16 Days
$247.82
Details
Human Rabbit Un-conjugated IP, ELISA, WB Human PILR-alpha/PILRA Western blot (WB) 13556 100 μL 14 to 16 Days
$247.82
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$446.88
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg 11 to 14 Days
$1,145.83
Details
Human Sheep Un-conjugated FACS   100 μg 11 to 14 Days
$1,145.83
Details
Human Mouse Un-conjugated WB   100 μg 11 to 14 Days
$969.83
Details
Mouse Rabbit Un-conjugated ELISA   100 μL 14 to 16 Days
$183.12
Details
Human Mouse Un-conjugated ELISA, WB PILRA monoclonal antibody (M01), clone 3C2 Western Blot analysis of PILRA expression in Hela S3 NE . Detection limit for recombinant GST tagged PILRA is approximately 3ng/ml as a capture antibody. 100 μg 11 to 12 Days
$440.00
Details

More Antibodies against PILRA Interaction Partners

Human Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA) interaction partners

  1. We propose that PILRA G78R protects individuals from Alzheimer's disease risk via reduced inhibitory signaling in microglia and reduced microglial infection during HSV-1 recurrence.

  2. Data suggest that, although PILRA exhibits essentially the same recognition of different glycopeptides, slight modifications of linker sugar cause significant changes in a wide area of the binding interface, resulting in a reduction of binding affinity; analogs/fragments of gpb were used in these studies. (PILRA = paired immunoglobin like type 2 receptor alpha; gpb = envelope glycoprotein B, Herpes simplex virus type 1)

  3. The interaction of NK cells with PILRalpha expressing targets lead to elevated IFNgamma secretion and cytotoxicity. In conclusion, PILRalpha is a novel NK activating ligand which binds and activates an unknown NK receptor expressed on a unique NK cell subset.

  4. Transcriptome wide association study results identified two novel genes as statistically significantly associated with nonobstructive azoospermia susceptibility: PILRA and ZNF676.

  5. PILRalpha exhibits large conformational change to recognize simultaneously both the sTn O-glycan and the compact peptide structure constrained by proline residues

  6. These results contribute our knowledge of the biological functions of HBVDNAPTP1 and provide novel data to aid in the further analysis of the regulatory mechanism of this protein.

  7. We demonstrated that three residues (Y2, R95, and W108) presented on the surface of PILRalpha form the sialic acid binding site equivalent to those in siglecs but are arranged in a unique linear mode.

  8. The amino terminus of herpes simplex virus 1 gK is functionally and physically associated with the gB-PILRalpha protein complex and regulates membrane fusion of the viral envelope with cellular membranes during virus entry.

  9. The authors show that the human ocular and highly neurovirulent HSV-1 strain McKrae enters substantially more efficiently into cells via the gB-specific human paired immunoglobulin-like type-2 receptor-alpha (hPILR-alpha).

  10. Data show that PILRalpha/ligand interactions require conserved PILRalpha arginine (Arg)-133 (mouse) and Arg-126 (human).

  11. These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha.

  12. PILRalpha protein was successfully crystallized at 293 K using the sitting-drop vapour-diffusion method and the crystals diffracted to 1.3 A resolution.

  13. The results demonstrate that cellular receptors for both gB and gD are required for HSV-1 infection and that PILRalpha plays an important role in HSV-1 infection as a coreceptor that associates with gB.

  14. viral entry via PILRalpha appears to be conserved but that there is a PILRalpha preference among alphaherpesviruses

  15. Insertional mutations of gB reduced cell fusion activity when PILRalpha was overexpressed much more than nectin-1.

Mouse (Murine) Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA) interaction partners

  1. Data suggest that immune inhibitory receptor, PILRalpha, plays an important role in the prevention of obesity and liver fibrosis.

  2. Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase.

  3. negatively regulates inflammatory colitis by reducing the neutrophil and macrophage infiltration

  4. demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilralpha is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation

  5. Data indicate paired Ig-like type 2 receptor (PILR)alpha Pilra-/- mice develop enhanced autoimmune arthritis.

  6. regulates neutrophil recruitment in inflammatory responses modulation of integrin activation

  7. Data show that PILRalpha/ligand interactions require conserved PILRalpha arginine (Arg)-133 (mouse) and Arg-126 (human).

  8. These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha.

  9. abilities of HSV-1 to enter cells in a PILRalpha-dependent manner and to acquire specific carbohydrates on gB are therefore linked to an increase in viral replication and virulence

  10. Domain V of paired Ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion.

  11. Activation of PILRa or deletion of PILRb helps to control acute Staphylococcus aureus-mediated pneumonia and attenuate the inflammatory response.

PILRA Antigen Profile

Protein Summary

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

Gene names and symbols associated with PILRA

  • paired immunoglobin like type 2 receptor alpha (PILRA) antibody
  • paired immunoglobulin-like type 2 receptor alpha (LOC489841) antibody
  • paired immunoglobin-like type 2 receptor alpha (Pilra) antibody
  • AV021745 antibody
  • FDF03 antibody
  • PILRA antibody
  • RGD1562847 antibody

Protein level used designations for PILRA

paired immunoglobulin-like type 2 receptor alpha , paired immunoglobin-like type 2 receptor alpha , cell surface receptor FDF03 , inhibitory receptor PILR-alpha

GENE ID SPECIES
463597 Pan troglodytes
489841 Canis lupus familiaris
100137734 Bos taurus
29992 Homo sapiens
231805 Mus musculus
288568 Rattus norvegicus
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