Protein Summary

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

Gene names and symbols associated with PILRA

• paired immunoglobin like type 2 receptor alpha (PILRA) antibody
• paired immunoglobulin-like type 2 receptor alpha (LOC489841) antibody
• paired immunoglobin-like type 2 receptor alpha (Pilra) antibody

• AV021745 antibody
• FDF03 antibody
• PILRA antibody
• RGD1562847 antibody

Protein level used designations for PILRA

paired immunoglobulin-like type 2 receptor alpha , paired immunoglobin-like type 2 receptor alpha , cell surface receptor FDF03 , inhibitory receptor PILR-alpha