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The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. Additionally we are shipping Paired Immunoglobin-Like Type 2 Receptor beta Antibodies (27) and Paired Immunoglobin-Like Type 2 Receptor beta Proteins (7) and many more products for this protein.
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PILRbeta differs from PILRalpha in one of the three residues (Y2, R95 and W108) on the surface of PILRalpha (L108), explaining its inability to engage gB.
Characterization of paired counterpart PILRA.
Data show that PILRbeta is important for regulating aberrant inflammatory responses through IL-27 production.
Activation of PILRa or deletion of PILRb helps to control acute Staphylococcus aureus-mediated pneumonia and attenuate the inflammatory response.
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. Alternatively spliced transcript variants have been noted for this gene, but the full-length nature of many is not known.
activating receptor PILR-beta
, activating receptor PILRbeta
, cell surface receptor FDFACT
, cell surface receptor FDFACT1
, cell surface receptor FDFACT2
, paired immunoglobin-like receptor beta
, paired immunoglobulin-like receptor beta
, paired immunoglobulin-like type 2 receptor beta
, immunoglobulin-like cell surface receptor FDFACT, activating counterpart