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The DNA-associated protein encoded by PRRX1 is a member of the paired family of homeobox proteins localized to the nucleus. Additionally we are shipping PRRX1 Proteins (8) and PRRX1 Kits (4) and many more products for this protein.
Showing 10 out of 92 products:
Human Polyclonal PRRX1 Primary Antibody for IHC, IHC (p) - ABIN4348068
Hardin, Guo, Shan, Montemayor-Garcia, Asioli, Yu, Harrison, Chen, Lloyd: The roles of the epithelial-mesenchymal transition marker PRRX1 and miR-146b-5p in papillary thyroid carcinoma progression. in The American journal of pathology 2014
Show all 3 Pubmed References
Human Polyclonal PRRX1 Primary Antibody for ICC, IF - ABIN449553
Reichert, Takano, von Burstin, Kim, Lee, Ihida-Stansbury, Hahn, Heeg, Schneider, Rhim, Stanger, Rustgi: The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis. in Genes & development 2013
Show all 2 Pubmed References
Human Polyclonal PRRX1 Primary Antibody for WB - ABIN1881690
Jiang, Stefanovic: Homeobox gene Prx1 is expressed in activated hepatic stellate cells and transactivates collagen alpha1(I) promoter. in Experimental biology and medicine (Maywood, N.J.) 2008
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Human Monoclonal PRRX1 Primary Antibody for ELISA, WB - ABIN1327183
Hirata, Sugimachi, Takahashi, Ueda, Sakimura, Uchi, Kurashige, Takano, Nanbara, Komatsu, Saito, Shinden, Iguchi, Eguchi, Atsumi, Sakamoto, Doi, Hirakawa, Honda, Mimori: Downregulation of PRRX1 Confers Cancer Stem Cell-Like Properties and Predicts Poor Prognosis in Hepatocellular Carcinoma. in Annals of surgical oncology 2014
Human Monoclonal PRRX1 Primary Antibody for IHC, WB - ABIN2674295
Guo, Fu, Wei, Lu, Feng, Zhang: PRRX1 promotes epithelial-mesenchymal transition through the Wnt/?-catenin pathway in gastric cancer. in Medical oncology (Northwood, London, England) 2014
LGR5 (show LGR5 Antibodies)-expressing fraction of CD54 (show ICAM1 Antibodies)+ cells represents gastric cancer CSCs, in which LGR5 (show LGR5 Antibodies) is closely associated with stemness and EMT (show ITK Antibodies) core genes
miR (show MLXIP Antibodies)-655 inhibits the acquisition of the epithelial-mesenchymal transition phenotype in triple-negative breast cancer by down-regulating Prrx1, thereby inhibiting cell migration and invasion during cancer progression.
Decreased Expression of PRRX1 was Associated with Hepatocellular Carcinoma.
the switch from Prrx1b to Prrx1a governs EMT (show ITK Antibodies) plasticity in both mouse models of PDAC and human PDAC
These findings demonstrate that PRRX1 promotes epithelial-mesenchymal transition in gastric cancer cells
Our results indicate that activation of Notch (show NOTCH1 Antibodies) signaling by PRRX1 is associated with the promotion of glioblastoma cell invasion.
We conclude that miR (show MLXIP Antibodies)-146b-5p has a role in cell proliferation and invasion, and that PRRX1 plays an important role in papillary thyroid carcinoma epithelial-mesenchymal transition and disease progression.
Overexpression of PRRX1 in stably overexpressed-miR (show MLXIP Antibodies)-124 cell lines could rescue the effects of radiosensitivity enhancement brought by miR (show MLXIP Antibodies)-124.
In the rare variant joint analysis, damaging variants within the PRRX1 region showed significant association with AF.
PRRX1 is an indicator of metastasis and poor prognosis in colorectal cancer cases.
Postnatal PRX1 (show PRDX1 Antibodies)-expressing stem cells of the calvaria are required for bone regeneration.
Data show that p38alpha (show MAPK14 Antibodies) mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) in paired related homeobox 1 protein (Prx1 (show PRDX1 Antibodies)+) bone marrow-derived mesenchymal stromal cells acts to preserve the bone by sustaining osteoprotegerin (OPG (show TNFRSF11B Antibodies)) production.
These data suggest the presence of a novel oxidative-stress-handling pathway where the anti-p53 (show TP53 Antibodies) molecule fortilin (show TPT1 Antibodies) augments the peroxidase PRX1 (show PRDX1 Antibodies) by protecting it against degradation and inactivation of the enzyme.
Induction of Prx1 (show PRDX1 Antibodies) by hypoxia regulates heme oxygenase-1 (show HMOX1 Antibodies) via NF-kappaB (show NFKB1 Antibodies) in oral cancer.
PRX-1 has a regulatory role in NF-kappaB (show NFKB1 Antibodies) nuclear translocation.
The data of this study suggested that Prx1 (show PRDX1 Antibodies) plays an important role as a key switch for neural cell lineage determination and the maintenance of the self-renewal of adult NSCs at several stages in the adult brain.
These observations suggest that increased Prrx1 expression may promote TGFbeta (show TGFB1 Antibodies) activity in adipose tissue and thereby contribute to aberrant adipocyte function during obesity.
The two isoforms, Prrx1a and Prrx1b, regulate migration and invasion, respectively, in pancreatic cancer cells
The results suggested that scarless skin-wound healing may require activation of the prx1 (show PRDX1 Antibodies) limb enhancer, and competence to activate the enhancer is probably a prerequisite for epimorphic regeneration, such as limb regeneration.
These results identify the homeobox protein (show HOXA1 Antibodies) Prx1 (show PRDX1 Antibodies) as an obligate mediator of TNF (show TNF Antibodies) inhibition of Osx (show SP7 Antibodies) and differentiation of osteoblast progenitors.
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns.
paired mesoderm homeo box 1
, paired related homeobox 1
, paired mesoderm homeobox 1
, paired mesoderm homeobox protein 1
, similar to PEPP subfamily gene 2
, homeobox protein PHOX1
, paired mesoderm homeobox 1 isoform pmx-1b
, paired-related homeobox protein 1
, homeobox protein K-2
, homeobox protein mHox
, homeobox protein MHOX
, paired-related homeotic gene product