anti-Paired-Like Homeobox 2b (PHOX2B) Antibodies

The DNA-associated protein encoded by PHOX2B is a member of the paired family of homeobox proteins localized to the nucleus. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PHOX2B 8929 Q99453
PHOX2B 18935 O35690
PHOX2B 364152  
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Top anti-PHOX2B Antibodies at

Showing 10 out of 62 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: Phox2b Sample Type: Rat Stomach lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
Mouse Rabbit Un-conjugated IF, WB PHOX2B Antibody (Center) (ABIN655288) western blot analysis in mouse liver tissue lysates (35 µg/lane). This demonstrates the PHOX2B antibody detected the PHOX2B protein (arrow). 400 μL Log in to see 10 to 11 Days
Mouse Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of PHOX2B using Jurkat whole cell lysates 100 μL Log in to see 11 to 12 Days
Human Rabbit Un-conjugated EIA, WB   0.4 mL Log in to see 8 to 11 Days
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using PHOX2B antibody. 100 μL Log in to see 16 Days
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
Chicken Goat Un-conjugated ELISA   100 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of PHOX2B in 293 cell lysate with PHOX2B polyclonal antibody  at (lane 1) 1 and (lane 2) 2 ug/mL. 100 μg Log in to see 11 to 12 Days

Top referenced anti-PHOX2B Antibodies

  1. Human Polyclonal PHOX2B Primary Antibody for ELISA - ABIN449850 : McGaughey, Vinton, Huynh, Al-Saif, Beer, McCallion: Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b. in Genome research 2008 (PubMed)

  2. Mouse (Murine) Polyclonal PHOX2B Primary Antibody for IF, WB - ABIN655288 : Burbach, Hellemons, Grant, Pant: The homeodomain transcription factor Phox2 in the stellate ganglion of the squid Loligo pealei. in Biology open 2015 (PubMed)

More Antibodies against PHOX2B Interaction Partners

Zebrafish Paired-Like Homeobox 2b (PHOX2B) interaction partners

  1. reduced dosage of PHOX2B during development, through either a heterozygous deletion or dominant-negative mutation, imposes a block in the differentiation of sympathetic neuronal precursors

  2. Phox2b is expressed throughout the primary taste centers of two cyprinid fish, Danio rerio and Carassius auratus

  3. Phox2b function is sox10 (show SOX10 Antibodies)-dependent in the developing enteric nervous system

Human Paired-Like Homeobox 2b (PHOX2B) interaction partners

  1. The primary cause of Congenital central hypoventilation syndrome is the mutation of the paired-like homeobox (show Lbx1 Antibodies) PHO2XB gene, found in 90% of the patients.

  2. PHOX2B is a highly sensitive and specific immunohistochemical marker for peripheral neuroblastic tumours, including neuroblastoma (show ARHGEF16 Antibodies).

  3. The authors found frequent, weak to moderate PHOX2B expression in phaeochromocytomas/paragangliomas and no expression in well-differentiated neuroendocrine tumours (WDNETs), which could be diagnostically useful in the distinction of these tumours.

  4. PHOX2B gene mutation results in a cytosine to thymine substitution changing the amino acid at codon 82 from proline to leucine.

  5. The discovery of gain-of-function mutations in the ALK receptor tyrosine kinase (show RET Antibodies) gene as the major cause of familial neuroblastoma (show ARHGEF16 Antibodies) led to the discovery of identical somatic mutations and rapid advancement of ALK as a tractable therapeutic target. Inactivating mutations in a master regulator of neural crest development, PHOX2B, have also been identified in a subset of familial neuroblastomas.

  6. Given the association between congenital heart disease and aberrant neural crest cell development, however, findings are suggestive that congenital heart disease may be a rare feature of PHOX2B mutation which has not been previously reported

  7. This study is the first to evaluate minimal residual disease detection using neuroblastoma (show ARHGEF16 Antibodies) mRNAs in human ovarian tissue. Only PHOX2B was a reliable marker of neuroblastoma (show ARHGEF16 Antibodies) cells contaminating ovarian tissue.

  8. This truncated protein localized to the nucleus and transactivated a target promoter. These data suggest that nonsense pathogenic variants in the first exon of PHOX2B likely escape nonsense mediated decay (NMD) and produce N-terminally truncated proteins functionally distinct from those produced by the more common polyalanine repeat mutations (PARMs).

  9. These pre-clinical data strongly suggest that PHOX2B functions as a suppressor of neuroblastoma (show ARHGEF16 Antibodies) progression.

  10. High PHOX2B expression is associated with Neuroblastoma (show ARHGEF16 Antibodies).

Mouse (Murine) Paired-Like Homeobox 2b (PHOX2B) interaction partners

  1. This study demonstrated that the Phox2b distinguishes between oral and non-oral sensory neurons in the geniculate ganglion in mice.

  2. Murine models of congenital central hypoventilation syndrome designed with PHOX2B mutations have suggested RTN neuron agenesis.

  3. The retrotrapezoid nucleus neurons expressing Atoh1 (show ATOH1 Antibodies) and Phox2b are essential for the respiratory response to CO2.

  4. Adult Phox2b(+/-) mice showed altered exploratory behavior in the open field and in the elevated plus maze, both indicative of anxiety. Phox2b(+/-) mice did not show cognitive or motor impairments.

  5. many cranial nerve-associated crest cells coexpress the pan (show SUPT6H Antibodies)-autonomic determinant Paired-like homeodomain 2b (Phox2b) together with markers of Schwann cell precursors. Some give rise to Schwann cells after down-regulation of PHOX2b.

  6. In this review, conditional mouse mutants of Phox2b(27Ala) lacked the ventilary response to hypercapnia at birth.

  7. Phox2b transcripts were identified in FAC (show FANCC Antibodies)-sorted Pitx3 (show PITX3 Antibodies) positive neurons.

  8. This study demonistrated that Phox2b-expressing retrotrapezoid neurons are intrinsically responsive to H+ and CO2.

  9. Nonpolyalanine repeat expansion mutation of PHOX2B is both a dominant-negative and gain-of-function mutation.

  10. The PHOX2B can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching.

PHOX2B Antigen Profile

Protein Summary

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.

Gene names and symbols associated with PHOX2B

  • paired-like homeobox 2b (phox2b) antibody
  • paired like homeobox 2b S homeolog (phox2b.S) antibody
  • paired-like homeobox 2bb (phox2bb) antibody
  • paired like homeobox 2b (PHOX2B) antibody
  • paired like homeobox 2b (phox2b) antibody
  • paired-like homeobox 2b (Phox2b) antibody
  • Dilp1 antibody
  • NBLST2 antibody
  • NBPhox antibody
  • phox2 antibody
  • PHOX2B antibody
  • Pmx2b antibody
  • xphox2b antibody

Protein level used designations for PHOX2B

paired-like homeobox 2b , paired mesoderm homeobox protein 2B , PHOX2B homeodomain protein , neuroblastoma Phox , neuroblastoma paired-type homeobox protein , paired mesoderm homeobox 2b , GENA 269 , dilated pupils 1

402787 Xenopus laevis
495120 Xenopus laevis
544654 Danio rerio
701940 Macaca mulatta
739088 Pan troglodytes
100124329 Xenopus (Silurana) tropicalis
8929 Homo sapiens
18935 Mus musculus
395548 Gallus gallus
610284 Canis lupus familiaris
783703 Bos taurus
364152 Rattus norvegicus
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