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PITX1 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Additionally we are shipping PITX1 Antibodies (55) and PITX1 Kits (9) and many more products for this protein.
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As a transcriptional activator, PITX1 regulates apoptosis-related genes, including PDCD5 (show PDCD5 Proteins), during gastric carcinogenesis.
we demonstrated a novel oncogenic mechanism of PTP1B (show PTPN1 Proteins) on affecting PITX1/p120RasGAP (show RASA1 Proteins) in colorectal carcinoma(CRC (show CALR Proteins)). Regorafenib inhibited CRC (show CALR Proteins) survival through reserving PTP1B (show PTPN1 Proteins)-dependant PITX1/p120RasGAP (show RASA1 Proteins) downregulation. PTP1B (show PTPN1 Proteins) may be a potential biomarker predicting regorafenib effectiveness, and a potential solution for CRC (show CALR Proteins)
Methylation status of PITX1 and even more so of lincRNA C5orf66-AS1 is a promising prognostic biomarker in HNSCC, in particular for HPV-negative patients. Further prospective evaluation is warranted
role for E2F1 (show E2F1 Proteins) and TFDP1 (show TFDP1 Proteins) in the transcriptional regulation of PITX1 in articular chondrocytes
PITX1 expression may be involved in tumor progression and is a potential tumor suppressor gene and prognostic marker for cutaneous malignant melanoma.
PTP1B (show PTPN1 Proteins) dephosphorylates PITX1 to weaken its protein stability and the transcriptional activity for p120RasGAP (show RASA1 Proteins) gene expression
To date, at least ten loci and four non-syndromic polydactyly-causing genes, including the GLI3 (show GLI3 Proteins) gene, the ZNF141 gene, the MIPOL1 (show MIPOL1 Proteins) gene and the PITX1 gene, have been identified. (Review)
Low PITX1 expression is associated with lung metastasis in osteosarcoma.
We discuss the genetic abnormality that causes Liebenberg syndrome, the genomic rearrangement at the PITX1 locus on chromosome 5.
Down-regulation of PITX1 expression might contribute to the progression of cutaneous malignant melanoma via promoting cell proliferative activity
Pitx1 distal enhancer loss have only mild effects on Pitx1 expression in the hindlimb and no overt effects on hindlimb or mandibular morphology.
data suggest that PITX1 promotes chondrogenesis and myogenesis in the hindlimb by direct regulation of several key members of the cartilage and muscle transcriptional networks.
Results indicate autonomously programmed differences in forelimb and hindlimb cartilage precursors of the limb skeleton are controlled, at least in part, by Pitx1 and suggest this has an important role in generating distinct limb-type morphologies.
Pitx1 targets sites that are in a similar chromatin state in Forelimbs (FLs) and hindlimbs and controls expression of patterning genes as well as the chondrogenic program.
Pitx1 influences hindlimb morphology both through the activation of hindlimb-specific enhancers as well as through the hindlimb-specific modulation of enhancers that are active in both sets of limbs
The results suggest that PITX2 (show PITX2 Proteins) and PITX1 have overlapping roles in thyrotroph function and response to hypothyroidism.
PITX1 haploinsufficiency may cause a developmental field defect preferentially affecting the lateral lower leg.
It was shown that, firstly, Pitx1 influences hindlimb outgrowth by regulating Tbx4 (show TBX4 Proteins) expression levels and that, subsequently,Pitx1 shapes hindlimb bone and soft tissue morphology independently of Tbx4 (show TBX4 Proteins).
These findings provide evidence that c-Abl (show ABL1 Proteins) participates in modulating Pitx1 expression in the apoptotic response to DNA damage.
Thus, Pitx1 and Pitx2 (show PITX2 Proteins) genes are required for sustained hindlimb bud growth and formation of hindlimbs
Pitx1 and the related protein Pitx2c (show PITX2 Proteins) are required for endogenous cement gland development. Pitx1 transcriptionally activates cement gland differentiation genes, both directly and indirectly
Pitx1 is expressed in hindlimbs and expression is similar in both developing and regenerating limb buds.
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.
paired-like homeodomain 1
, paired-like homeodomain transcription factor 1
, pituitary homeobox 1
, hindlimb expressed homeobox protein backfoot
, hindlimb-expressed homeobox protein backfoot
, homeobox protein PITX1
, pituitary homeo box 1
, pituitary otx-related factor
, homeobox protein P-OTX
, pituitary OTX-related factor