anti-Pannexin 1 (PANX1) Antibodies

The protein encoded by PANX1 belongs to the innexin family. Additionally we are shipping Pannexin 1 Kits (11) and Pannexin 1 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PANX1 24145 Q96RD7
PANX1 55991 Q9JIP4
PANX1 315435 P60570
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Top anti-Pannexin 1 Antibodies at

Showing 10 out of 69 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-PANX1 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Jurkat cell lysate 100 μL 2 to 3 Days
Human Rabbit Un-conjugated IF, ELISA, WB 0.1 mg 2 to 3 Days
Cow Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated ELISA, WB 100 μg 2 to 3 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of PANX1 using COLO205 whole cell lysates 100 μL 11 to 12 Days
Rat Rabbit Un-conjugated ICC, IHC, WB DAB staining on IHC-P; Samples: Rat Stomach Tissue 100 μg 13 to 16 Days
Human Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of (1) Human SK-N-SH Cells and (2) Human U-87MG Cells. Western blot analysis of recombinant Human PANX1. 100 μg 31 to 36 Days
Mammalian Rabbit Un-conjugated IHC, WB Pannexin 1 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of intestinal villus (arrows) in Human Intestine. Magnification is at 400X Pannexin 1 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Lane1: Human SK-N-SH Cells; Lane2: Human U-87MG Cells. Figure. Western Blot; Sample: Recombinant PANX1, Human. 100 μg 15 to 18 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of PANX1 in human ovary tissue with PANX1 polyclonal antibody  at 1 ug/mL. 100 μg 11 to 12 Days

More Antibodies against Pannexin 1 Interaction Partners

Zebrafish Pannexin 1 (PANX1) interaction partners

  1. Extracellular ATP hydrolysis via NTPDase1 action inhibits synaptic transmission by pannexin 1-mediated increase in pH buffering of the synaptic cleft.

  2. The existence of two Panx1 proteins in zebrafish displaying distinct tissue distribution, protein modification and electrophysiological properties, suggests that both proteins fulfill different functions in vivo.

  3. The function of panx1 channel is significantly reduced following mutation of a single cysteine residue (C282W) in the fourth transmembrane region of panx1.

  4. zfPanx1 displays properties similar to its mammalian homologues and can potentially play an important role in functions of the outer retina.

Human Pannexin 1 (PANX1) interaction partners

  1. These data suggest a proepileptic role of pannexin-1 channels in chronic epilepsy.

  2. Studies show that the Pannexin1 (Panx1) membrane channel responds to different stimuli with distinct channel conformations [Review].

  3. Stimulation of TRPV4 releases ATP via Pannexin channels in human pulmonary fibroblasts.

  4. Progressive PANX1 channel opening is directly linked to permeation of ions and large and occurs during both irreversible and reversible forms of channel activation. This unique, quantized activation process enables fine tuning of PANX1 channel activity and may be a generalized regulatory mechanism for other related multimeric channels.

  5. authors proposed a tentative intracellular signaling pathway of the acetylcholine-induced ciliary beat, in which the pannexin-1-purinergic P2X receptor unit may play a central role in ciliary beat regulation

  6. These results newly identify Pannexin-1 as a protein highly expressed in human dermal lymphatic endothelial cells.

  7. The pannexin 2 (Panx2) N86Q mutant is glycosylation-deficient and tends to aggregate in the endoplasmic reticulum (ER)reducing its cell surface trafficking but it can still interact with pannexin 1 (Panx1).

  8. All three pannexins Panx1, Panx2, and Panx3 mRNAs were expressed in all of the analyzed undifferentiated stem cell lines.

  9. These results elucidate for the first time PNX1-hemichannels as potentially main extracellular translocation pathway for NDKs from an intracellular pathogen.

  10. Pannexin1 (Panx1) was suggested to be functionally associated with purinergic P2X and N-methyl-D-aspartate (NMDA) receptor channels. Activation of these receptor channels by their endogenous ligands leads to cross-activation of Panx1 channels. This in turn potentiates P2X and NMDA receptor channel signaling.

  11. The ubiquitous expression, as well as its function as a major ATP release and nucleotide permeation channel, makes Panx1 a primary candidate for participating in the pathophysiology of CNS disorders.

  12. Panx1 was mainly distributed in microcolumn neurons, dysmorphic neurons, balloon cells and reactive astrocytes in cortical lesions from intractable epilepsy patients with focal cortical dysplasia.

  13. ATP release from red blood cells is not mediated by the cAMP-mediated Panx1 pathway.

  14. Panx1 channels are involved in beta-toxin-induced cell death.

  15. Pannexin1 is a mediator of inflammation and cell death. (Review)

  16. Panx1 channels promote skeletal muscle myoblast differentiation and fusion. (Review)

  17. presence of the Panx1-400C allele was not associated with platelet reactivity in stable cardiovascular patients.

  18. Overactive Panx-1 promotes cancer cell survival in the context of mechanical deformation. Panx-1 inhibitors can be used to treat highly metastatic cancer. Mechanosensitive Panx-1 channels will be a new target for the prevention of metastasis and stress-induced diseases.

  19. The results of this study do not support a major contribution of PANX1-3 to disease risk of schizophrenia according to DSM-5.

  20. a pivotal role of P2X7 receptor-pannexin-1 in oxysterols toxicity in retinal cells

Mouse (Murine) Pannexin 1 (PANX1) interaction partners

  1. These results show that high expression of the Panx1 channel in retinal ganglion cells is essential for visual function in the inner retina but makes these cells highly sensitive to mechanical and ischemic stresses.

  2. that Pannexin1 and Pannexin3 channels may play important and distinct roles in healthy and diseased skeletal muscles

  3. These data suggest a proepileptic role of pannexin-1 channels in chronic epilepsy.

  4. In summary, we show the role of Panx1 channel as a defining factor in kidney response to IRI. We show that disrupting Panx1-mediated ATP release protects kidney function and histology.

  5. Atherosclerotic lesion development in response to high-cholesterol diet was enhanced in Panx1 (del) Apoe (-/-) mice, pointing to an atheroprotective role for Panx1 in endothelial and/or monocytic cells. Unexpectedly, atherogenesis was not changed in mice with ubiquitous Panx1 deletion, but Panx1 (-/-) Apoe (-/-) mice displayed reduced body weight, serum cholesterol, triglycerides and free fatty acids.

  6. endothelial Panx1 plays a key role in mediating vascular permeability, inflammation, edema, leukocyte infiltration, and lung dysfunction after I/R.

  7. Study demonstrates that Panx1 was an abundant form of pannexins in podocytes, and it could mediate anion conductance across plasma membrane to transport ATP. This Panx1 channel was found to be inhibited by adiponectin via acid ceramidase activation and consequent production of sphingosine-1-phosphate.

  8. The purinergic channel pannexin1, the ATP-gated purinergic receptor P2 x 7R and the low voltage transiently opened T-type calcium channel CaV3.2-1 all reside in close proximity to beta3 integrin attachment foci on osteocyte processes, suggesting a specialized mechanotransduction complex at these sites.

  9. Through a combination of pharmacological tools and behavioral tests, authors showed that the downregulation of Panx1 in chronic social defeat stress model results in lacking of extracellular ATP in the medial prefrontal cortex, and then contributes to the depressive-like behaviors. Results indicate that Panx1 may be a key component of a signaling pathway which mediates the psychiatric side effects of mefloquine.

  10. Panx1 expressed in immune cells is critical for pain-like effects following nerve injury in mice, perhaps via a GPCR-mediated activation mechanism, and suggest that inhibition of Panx1 may be useful in treating neuropathic pain.

  11. Auditory brainstem response thresholds in the Gen-Panx1 KO mouse were significantly increased. Distortion product otoacoustic emission and cochlear microphonics were significantly reduced.

  12. These novel findings reveal unique roles for GFAP-positive glial and neuronal Panx1 and describe new chronic pain targets for cell-type specific intervention in this often intractable disease.

  13. Panx-1 modulation may be interesting to amplify the clinical effect of cisplatin (DDP) and reverse the resistance of testicular cancer cells to DDP.

  14. Pannexin1 may play a role in the pathogenesis of liver disease.

  15. Findings indicate a deleterious role for membrane channel Pannexin 1 (Panx1) in response to permanent permanent middle cerebral artery (MCA) occlusion, that is unique to females.

  16. ATP release from red blood cells is not mediated by the cAMP-mediated Panx1 pathway.

  17. blocking Panx1 and/or Casp4 activities is a beneficial strategy to enhance donor cell engraftment and LG regeneration through the reduction of inflammation.

  18. found a significant increase in waking and a correspondent decrease in slow wave sleep percentages in the Panx1-/- animals.

  19. Diabetic C57BL/6J-Ins2Akita mice were used to evaluate in vivo effects of high glucose on P2R and Panx1

  20. Pharmacological blockade or genetic deletion of Panx1 channels inhibits CD4+ T lymphocyte polarization and migration induced by the chemokine SDF-1alpha/CXCL12. Panx1 deficiency delayed experimental autoimmune encephalomyelitis symptoms because of the decreased infiltration of CD4+ T lymphocytes into the CNS.

Pannexin 1 (PANX1) Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.

Gene names and symbols associated with anti-Pannexin 1 (PANX1) Antibodies

  • pannexin 1a (panx1a) antibody
  • pannexin 1 (PANX1) antibody
  • pannexin 1 (panx1) antibody
  • pannexin 1 (Panx1) antibody
  • Pannexin 1 (Panx1) antibody
  • AI847747 antibody
  • MRS1 antibody
  • Pannexin-1 antibody
  • pannexin1 antibody
  • PANX1 antibody
  • PX1 antibody
  • UNQ2529 antibody
  • zgc:55631 antibody

Protein level used designations for anti-Pannexin 1 (PANX1) Antibodies

pannexin 1 , pannexin-1 , innexin

393890 Danio rerio
466751 Pan troglodytes
697204 Macaca mulatta
772164 Gallus gallus
100014304 Monodelphis domestica
100170473 Xenopus (Silurana) tropicalis
100171730 Pongo abelii
24145 Homo sapiens
607532 Canis lupus familiaris
528169 Bos taurus
55991 Mus musculus
315435 Rattus norvegicus
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