Paraoxonase 1 Proteins (PON1)

The enzyme encoded by PON1 is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Additionally we are shipping Paraoxonase 1 Antibodies (190) and Paraoxonase 1 Kits (80) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PON1 5444 P27169
PON1 18979 P52430
PON1 84024 P55159
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Top Paraoxonase 1 Proteins at

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Human GST tag 100 μg Log in to see 11 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

PON1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Paraoxonase 1 (PON1) Interaction Partners

Human Paraoxonase 1 (PON1) interaction partners

  1. PON1 gene Q192R and L55M polymorphisms are not associated with Crimean-Congo hemorrhagic fever.

  2. Minor allele frequencies (MAF) in a Puerto Rican population were 46% for PON1 (rs662), 41% for ABCB1 (rs1045642), 14% for CYP2C19*17, 13% for CYP2C19*2, 12% for P2RY12-H2 and 0.3% for CYP2C19*4. No carriers of the CYP2C19*3 variants were detected. All alleles and genotype proportions were found to be in HardyWeinberg equilibrium (HWE).

  3. results demonstrated increased CETP and decreased LCAT and PON-1 activities in colorectal cancer (CRC)patients. In preliminary analysis CETP mass was identified as potential significant predictor of CRC development, suggesting that alterations in HDL-C levels, alongside with changes in HDL structure might have a role in carcinogenesis.

  4. The single nucleotide polymorphism rs662 of PON1 was not correlated with male infertility, which, however, needs to be confirmed by further studies with larger samples from a larger area.

  5. Results found that total protein concentration and PON1 activity in serum were significantly higher in OA patients. Also, the systemic response to osteoarthritis (serum PON1 activity) was higher about 33.6% in men than women and not dependent on affected joint.

  6. serum levels decrease in states of high oxidative stress like metabolic syndrome, obesity, uncontrolled diabetes, and dyslipidemia

  7. CD was found to be associated with the decrease in the levels of PON-1, which correlates well with activity of the disease and reflects the intensification of inflammation, as well as intensified lipid peroxidation. High sensitivity and specificity of PON-1 determines its selection as a good screening test for CD severity.

  8. The analysis of the effect of the individual SNPs(PON1, IL-6, ITGB3, and ALDH2 ) and GRS groups on different lipid profile parameters revealed no significant association of any of the tested SNPs with any lipid parameter, however, the GRS groups showed marginally significant for TC and highly significant association for TG, LDL-c and HDL-c

  9. It findings provide genetic evidence that the PON1-L55M variant may be a factor contributing to the glycemic control in type 2 diabetes.

  10. Low serum paraoxonase 1 activity is associated with the development of type 2 diabetes mellitus.

  11. T allele and TT genotype are associated with COPD, and the PON1-108C>T polymorphism could be a potential predictor of the disease.

  12. study showed that altered HDL subclasses distribution, changed PON1 activities on different HDL subclasses as well as diminished anti-oxidative protection could be important factors in atherosclerosis development in CKD and ESRD patients

  13. Data suggest that patients with ARF (acute renal failure) caused by septic shock have low serum PON1 activities, cholesterol, and HDL-cholesterol; high serum PON1 activities are associated with severity of septic shock; extra-renal depuration techniques produce further increases in serum PON1 activities related to duration of stay in ICU and increases in serum urea levels. This study was conducted in Spain.

  14. Studied association of genetic polymorphisms of paraoxanase 1(PON1) in Turkish patients with pulmonary embolism (PE). Results suggest that there is no relationship between both PON 1 polymorphisms and PE in the Turkish population.

  15. Low PON1 expression is associated with breast cancer.

  16. serum concentrations of trace elements and their relationships with paraoxonase-1 in morbidly obese women

  17. Low PON1 expression is associated with Atherosclerosis.

  18. The aim of this study was to investigate whether obesity is associated with PON1 activity and whether this association is influenced by oxidative stress, inflammation and HDL cholesterol (HDL-C) concentration.

  19. Our results showed that ApoE epsilon4 and PON1-55M alleles act synergistically to increase the risk of systemic lupus erythematosus by 1.47 times

  20. Low PON1 expression is associated with endometrial cancer.

Mouse (Murine) Paraoxonase 1 (PON1) interaction partners

  1. Study shows that PON1 can significantly relieve airway inflammation and airway remolding in asthma mice, and inhibit the secretion of LPS induced macrophage inflammatory cytokines and the proliferation of lung fibroblasts. These results suggest that PON1 may be involved in airway inflammation and remodeling in asthma.

  2. PON1 overexpression protects against AAA progression by reducing oxidative stress, apoptosis and inflammation

  3. Paraoxonase 1 (PON1) influence circadian gene expression and period length

  4. results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL, owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis.

  5. Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes.

  6. 5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1.

  7. HDL (mostly HDL3), stimulates PON1 antiatherogenic activities in mouse macrophages.

  8. Findings suggest that Pon1 interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis

  9. The study demonstrated a significant decline in PON1 activity which correlates with increased LDL oxidation after 8 months of age in Wistar rats.

  10. PON1 plays a protective role against hepatic derangements, secondary to fat and cholesterol overnutrition. PON1 deficiency is associated with oxidative stress and metabolic alterations leading to liver steatosis.

  11. PON1 is not essential for normal development, function, ageing, and the defense against light damage of the mouse retina.

  12. Suggest that PON1 decreases sustained pro-inflammatory reactions, which subsequently can attenuate plaque progression.

  13. PON1 plays a beneficial role in glucose regulation and metabolism and may serve as an important tool in diabetes control.

  14. PON1 activity was found to be increased in diabetic mice after administration of aqueous Murraya koenigii leaves extract.

  15. Pon1 protects mice against Hcy-thiolactone neurotoxicity by hydrolyzing it in the brain.

  16. PON1 is a potent anti-diabetic enzyme that exerts this protection against diabetes through its antioxidative, as well as via its insulin stimulation properties on beta-cells.

  17. antiatherosclerotic properties of HDL can be attributed to two major mechanisms of action of PON1: protecting macrophages from TG-induced oxidative modification and (ii) reduction of peroxide levels in oxidized TGs.

  18. PON1 status plays a critical role in modulating the effects of neonatal chlor- pyrifos oxon exposure in the developing brain.

  19. PON1 status modulates the ability of CaE to detoxicate OP compounds from specific mixed insecticide exposures [review]

  20. analysis of PON1 and oxidative stress in human sepsis and an animal model of sepsis [review]

Pig (Porcine) Paraoxonase 1 (PON1) interaction partners

  1. Western blotting analysis confirmed the presence of PON1 in all boar genital organs, showing in all of them a band of 51 kDa and an extra band of 45 kDa only in seminal vesicles

  2. PON1 behaves as a negative acute phase protein in pigs since a significant decrease (P<0.05) in its activity after 72 h of the induction of the inflammation was observed with all substrates.

Cow (Bovine) Paraoxonase 1 (PON1) interaction partners

  1. The PON1 activity in the seminal plasma was positively correlated with ejaculate's colour, sperm mass activity, motility, vigour and viability.Thus, PON1 may be a potential marker for sperm motility and viability in bulls.

  2. The results of this study indicate that there is no effect of serum PON1 activity on the diameter of preovulatory follicle or establishment of pregnancy in cows submitted to time of ovulation synchronization protocols.

  3. characterization the SNPs in the promoter region of the bovine PON1 gene, and to evaluation of association with serum PON1 activity in periparturient Holstein cows

  4. The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.

  5. Data indicate that Cu(2+), Mn(2+), Zn(2+), Ni(2+), and Pb(2+) were found to inhibite the paraoxonase 1 (PON1) enzyme activity in a concentration-dependent fashion.

  6. The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.

  7. The results indicate that lower serum paraoxonase activity and higher concentration of uric acid are associated with oxidative character of transition period and lipid functional antioxidative protection during intensive milk production.

  8. Significantly lower PON1 activity and PON1/high density lipoprotein ratio in lactating cows compared to heifers showed that metabolic efforts during pregnancy, parturition and lactation influence PON1 activity due to oxidative stress.

  9. The activity of PON1 and malondialdehyde in late pregnancy and early lactation in dairy cattle is reported.

Rabbit Paraoxonase 1 (PON1) interaction partners

  1. ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity

  2. PON1 can decrease the AChE inhibition, and alleviated clinical signs and tissue damage caused by dichlorvos.

Paraoxonase 1 (PON1) Protein Profile

Protein Summary

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Gene names and symbols associated with Paraoxonase 1 Proteins (PON1)

  • paraoxonase 2 (pon2)
  • paraoxonase 1 (PON1)
  • paraoxonase 1 (Pon1)
  • ESA protein
  • MGC53915 protein
  • MGC89222 protein
  • MVCD5 protein
  • Pon protein
  • PON1 protein
  • pon2 protein

Protein level used designations for Paraoxonase 1 Proteins (PON1)

paraoxonase 1 , paraoxonase 2 , serum paraoxonase/arylesterase 1-like , A-esterase 1 , K-45 , PON 1 , aromatic esterase 1 , arylesterase B-type , esterase A , paraoxonase B-type , serum aryldiakylphosphatase , serum aryldialkylphosphatase 1 , serum paraoxonase/arylesterase 1 , serum paraoxonase

448598 Xenopus (Silurana) tropicalis
463547 Pan troglodytes
699355 Macaca mulatta
100408915 Callithrix jacchus
100436640 Pongo abelii
100602768 Nomascus leucogenys
5444 Homo sapiens
18979 Mus musculus
84024 Rattus norvegicus
475234 Canis lupus familiaris
100048952 Sus scrofa
523798 Bos taurus
100009133 Oryctolagus cuniculus
100721268 Cavia porcellus
101116983 Ovis aries
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