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The enzyme encoded by PON1 is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Additionally we are shipping Paraoxonase 1 Antibodies (193) and Paraoxonase 1 Kits (81) and many more products for this protein.
Showing 10 out of 24 products:
Low PON1 expression is associated with Atherosclerosis.
The aim of this study was to investigate whether obesity is associated with PON1 activity and whether this association is influenced by oxidative stress, inflammation and HDL (show HSD11B1 Proteins) cholesterol (HDL (show HSD11B1 Proteins)-C) concentration.
Our results showed that ApoE (show APOE Proteins) epsilon4 and PON1-55M alleles act synergistically to increase the risk of systemic lupus erythematosus by 1.47 times
Low PON1 expression is associated with endometrial cancer.
The rs3735590 polymorphism of PON1 acts as a prognostic biomarker in COPD (show ARCN1 Proteins) patients treated by CABG.
Results showed significantly decreased levels of PON1 in patients with chronic liver diseases (controls 185 +/- 14 U/l, NAFLD 160 +/- 15 U/l, chronic hepatitis 99 +/- 18 U/l, cirrhosis (52 +/- 11 U/l).
Impaired anti-oxidant and anti-atherogenic HDL (show HSD11B1 Proteins) properties associated with weakened PON1 function and lipid peroxidation may contribute to the development of atherosclerosis-related diseases in T2DM.
the Q192R polymorphism in the PON1 gene is associated with familial hypercholesterolemia (FH) in the Saudi population; the R allele, QR, and dominant model genotypes were associated with FH
activity of PON1 in the control group was significantly higher in comparison with diabetic patients
PON1-L55M T alleles are associated with dementia risk.
Study shows that PON1 can significantly relieve airway inflammation and airway remolding in asthma mice, and inhibit the secretion of LPS (show TLR4 Proteins) induced macrophage inflammatory cytokines and the proliferation of lung fibroblasts. These results suggest that PON1 may be involved in airway inflammation and remodeling in asthma.
PON1 overexpression protects against AAA (show AAAS Proteins) progression by reducing oxidative stress, apoptosis and inflammation
Paraoxonase 1 (PON1) influence circadian gene expression and period length
results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL (show HSD11B1 Proteins), owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis.
Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes.
5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1.
HDL (show HSD11B1 Proteins) (mostly HDL3), stimulates PON1 antiatherogenic activities in mouse macrophages.
Findings suggest that Pon1 interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis
The study demonstrated a significant decline in PON1 activity which correlates with increased LDL oxidation after 8 months of age in Wistar rats.
PON1 plays a protective role against hepatic derangements, secondary to fat and cholesterol overnutrition. PON1 deficiency is associated with oxidative stress and metabolic alterations leading to liver steatosis.
Western blotting analysis confirmed the presence of PON1 in all boar genital organs, showing in all of them a band of 51 kDa and an extra band of 45 kDa only in seminal vesicles
PON1 behaves as a negative acute phase protein (show ORM1 Proteins) in pigs since a significant decrease (P<0.05) in its activity after 72 h of the induction of the inflammation was observed with all substrates.
The PON1 activity in the seminal plasma was positively correlated with ejaculate's colour, sperm mass activity, motility, vigour and viability.Thus, PON1 may be a potential marker for sperm motility and viability in bulls.
The results of this study indicate that there is no effect of serum PON1 activity on the diameter of preovulatory follicle or establishment of pregnancy in cows submitted to time of ovulation synchronization protocols.
characterization the SNPs in the promoter region of the bovine PON1 gene, and to evaluation of association with serum PON1 activity in periparturient Holstein cows
The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.
Data indicate that Cu(2+), Mn(2+), Zn(2+), Ni(2 (show VMP1 Proteins)+), and Pb(2+) were found to inhibite the paraoxonase 1 (PON1) enzyme activity in a concentration-dependent fashion.
The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.
Significantly lower PON1 activity and PON1/high density lipoprotein ratio in lactating cows compared to heifers showed that metabolic efforts during pregnancy, parturition and lactation influence PON1 activity due to oxidative stress.
The activity of PON1 and malondialdehyde in late pregnancy and early lactation in dairy cattle is reported.
ApoE (show APOE Proteins) mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Proteins) paraoxonase activity
PON1 can decrease the AChE inhibition, and alleviated clinical signs and tissue damage caused by dichlorvos.
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.
, paraoxonase 2
, serum paraoxonase/arylesterase 1-like
, A-esterase 1
, PON 1
, aromatic esterase 1
, arylesterase B-type
, esterase A
, paraoxonase B-type
, serum aryldiakylphosphatase
, serum aryldialkylphosphatase 1
, serum paraoxonase/arylesterase 1
, serum paraoxonase