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The enzyme encoded by PON1 is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol.
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PON1-L55M T alleles are associated with dementia risk.
PON1 Q192R polymorphism has a weak association with coronary heart disease risk in Chinese
PLA2G7 (show Lp-PLA2 Proteins) and PON1 are overexpressed in prostatic neoplasm patients and can be detected early in blood.
PON1 as an important candidate gene influencing genetic pathophysiology of polycystic ovarian syndrome.
It demonstrates that the impact of Y71 substitutions on PON1's lactonase activity is minimal, whereas the kcat for the paraoxonase activity is negatively perturbed by up to 100-fold, suggesting greater mutational robustness of the native activity.
genetic association studies in population of women in Greece: Data suggest than a genetic polymorphism in PON1 (Q192R) is associated with gestational diabetes in the population studied. Transcription of the PON1 gene does not appear to be impaired in leukocytes from women with gestational diabetes.
HDL (show HSD11B1 Proteins)-C, but not its anti-oxidant constituent, PON-1, is inversely, continuously and independently associated with future risk of hypertension.
In donor retina from patients with diabetes, all three PON1, PON2 (show PON2 Proteins) and PON3 (show PON3 Proteins) were expressed, and there was a significant increase in PON3 (show PON3 Proteins) expression compared to control. This might be the reason for the increased thiolactonase activity observed in diabetic retina compared to control
Serum PON1 levels showed that oxidative stress was severe in otosclerosis.
PON1 L55M genetic polymorphisms may be associated with the risk of breast cancer and could potentially serve as useful genetic markers for tumor prognosis in some populations of Chinese women.
Study shows that PON1 can significantly relieve airway inflammation and airway remolding in asthma mice, and inhibit the secretion of LPS (show TLR4 Proteins) induced macrophage inflammatory cytokines and the proliferation of lung fibroblasts. These results suggest that PON1 may be involved in airway inflammation and remodeling in asthma.
PON1 overexpression protects against AAA (show AAAS Proteins) progression by reducing oxidative stress, apoptosis and inflammation
Paraoxonase 1 (PON1) influence circadian gene expression and period length
results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL (show HSD11B1 Proteins), owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis.
Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes.
5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1.
HDL (show HSD11B1 Proteins) (mostly HDL3), stimulates PON1 antiatherogenic activities in mouse macrophages.
Findings suggest that Pon1 interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis
The study demonstrated a significant decline in PON1 activity which correlates with increased LDL oxidation after 8 months of age in Wistar rats.
PON1 plays a protective role against hepatic derangements, secondary to fat and cholesterol overnutrition. PON1 deficiency is associated with oxidative stress and metabolic alterations leading to liver steatosis.
Western blotting analysis confirmed the presence of PON1 in all boar genital organs, showing in all of them a band of 51 kDa and an extra band of 45 kDa only in seminal vesicles
PON1 behaves as a negative acute phase protein (show ORM1 Proteins) in pigs since a significant decrease (P<0.05) in its activity after 72 h of the induction of the inflammation was observed with all substrates.
characterization the SNPs in the promoter region of the bovine PON1 gene, and to evaluation of association with serum PON1 activity in periparturient Holstein cows
The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.
Data indicate that Cu(2+), Mn(2+), Zn(2+), Ni(2 (show VMP1 Proteins)+), and Pb(2+) were found to inhibite the paraoxonase 1 (PON1) enzyme activity in a concentration-dependent fashion.
The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.
Significantly lower PON1 activity and PON1/high density lipoprotein ratio in lactating cows compared to heifers showed that metabolic efforts during pregnancy, parturition and lactation influence PON1 activity due to oxidative stress.
The activity of PON1 and malondialdehyde in late pregnancy and early lactation in dairy cattle is reported.
ApoE (show APOE Proteins) mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Proteins) paraoxonase activity
PON1 can decrease the AChE inhibition, and alleviated clinical signs and tissue damage caused by dichlorvos.
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.
, paraoxonase 2
, serum paraoxonase/arylesterase 1-like
, A-esterase 1
, PON 1
, aromatic esterase 1
, arylesterase B-type
, esterase A
, paraoxonase B-type
, serum aryldiakylphosphatase
, serum aryldialkylphosphatase 1
, serum paraoxonase/arylesterase 1
, serum paraoxonase