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PNKD is thought to play a role in the regulation of myofibrillogenesis. Additionally we are shipping PNKD Proteins (5) and PNKD Kits (3) and many more products for this protein.
Showing 10 out of 41 products:
Human Polyclonal PNKD Primary Antibody for ICC, IF - ABIN4346528
Guo, Dong, Ji, Wu: Myofibrillogenesis regulator-1 overexpression is associated with poor prognosis of gastric cancer patients. in World journal of gastroenterology 2012
Human Polyclonal PNKD Primary Antibody for ICC, IF - ABIN4346527
Sadegh, Ekman, Krawczyk, Svensson, Göransson, Dahan, Nilsson, Albinsson, Uvelius, Swärd: Detrusor induction of miR-132/212 following bladder outlet obstruction: association with MeCP2 repression and cell viability. in PLoS ONE 2015
The short isoform of the myofibrillogenesis regulator 1 (MR-1S) as a new COX (show COX8A Antibodies) assembly factor, which works with the highly conserved PET100 and PET117 chaperones to assist COX (show COX8A Antibodies) biogenesis in higher eukaryotes.
The combined analysis identified a new risk association for colorectal cancer (CRC (show CALR Antibodies)) at 2q35 marked by rs992157 which is intronic to PNKD and TMBIM1 (show TMBIM1 Antibodies).Intriguingly this susceptibility single-nucleotide polymorphism (SNP) is in strong linkage disequilibrium (r(2) = 0.90, D' = 0.96) with the previously discovered GWAS SNP rs2382817 for inflammatory bowel disease (IBD).
study highlights the frequency, novel mutations and clinical and molecular spectrum of PRRT2, SLC2A1 and PNKD mutations as well as the phenotype-genotype overlap among these paroxysmal movement disorders.
This study present the pedigree is the first PNKD family from Chinese Mainland, which is also the largest PNKD family among those reported across the globe. It included 5 generations and 26 patients.
MR-1 (show MR1 Antibodies) functions as a tumor promoter in MCF7 cells by activating the MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) signaling
MR-1 overexpression was tightly associated with more aggressive tumor behavior and a poor prognosis in pancreatic ductal adenocarcinoma.
MR-1 was up-regulated in gastric cancer tissues. High expression of MR-1 in gastric cancer was significantly correlated with clinical stage. Postoperative survival of the MR-1 positive group tended to be poorer than that of the MR-1 negative group.
A Taiwanese family with paroxysmal nonkinesigenic dyskinesia has a heterozygous c.20 C>T (p.Ala7Val) mutation which was clearly segregated in the five affected patients.
In this report we present two families with paroxysmal non-kinesigenic dyskinesia of Southern European origin carrying a PNKD protein recurrent mutation.
Mutations in PNKD causing paroxysmal dyskinesia alters protein cleavage and stability.
PNKD KO mice, RIM1/2 protein levels are reduced and synaptic strength is impaired. Thus, PNKD is a novel synaptic protein with a regulatory role in neurotransmitter release
These findings support the hypothesis that the PNKD protein functions to modulate striatal neuro-transmitter release in response to stress and other precipitating factors.
these findings suggest that silencing MR-1 (show MR1 Antibodies) protected mice myocardium against inflammatory injury induced by AngII by suppression of pro-inflammatory transcription factors NF-kappaB (show NFKB1 Antibodies) and AP-1 (show JUN Antibodies) signaling pathway.
MR-1 plays an aggravative role in the development of cardiac hypertrophy via activation of the nuclear factor kappaB signaling pathway
Paroxysmal non-kinesigenic dyskinesia (PNKD) is characterized by spontaneous hyperkinetic attacks that are precipitated by alcohol, coffee, stress and fatigue.
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants.
brain protein 17
, myofibrillogenesis regulator 1
, probable hydrolase PNKD
, trans-activated by hepatitis C virus core protein 2
, paroxysmal nonkinesiogenic dyskinesia
, paroxysmal nonkinesiogenic dyskinesia protein