Patatin-Like phospholipase Domain Containing 3 Proteins (PNPLA3)

Human Patatin-Like phospholipase Domain Containing 3 (PNPLA3) interaction partners

1. PNPLA3 determines the risk of NASH (show SAMSN1 Proteins) and significant fibrosis.

2. Our study suggested that PNPLA3 loci (rs2294918, rs2294919) were associated with HBV-related HCC in Han Chinese.

3. In this Sri (show SRI Proteins) Lankan community cohort study, the annual incidence of non-alcoholic fatty liver disease (NAFLD) was 6.2%. Incident NAFLD was associated with general and central obesity, raised triglycerides and diabetes, and showed a tendency of association with PNPLA3 gene polymorphisms.

4. Deleterious and protective mutations in MTTP, PNPLA3, and TM6SF2 have been found in Japanese males at risk for non-alcoholic fatty liver disease.

5. Although no single variant reached genome-wide significance, an association signal was observed for PNPLA3 rs738409, a common single nucleotide polymorphism that has been associated with a variety of liver-related pathologies including alcoholic cirrhosis. This preliminary analysis suggests a role for PNPLA3 variation and several gene sets/pathways that may influence risk for alcoholic hepatitis among heavy drinkers.

6. These findings suggest that PNPLA3 rs1010023 may predispose chronic hepatitis B patients to hepatic steatosis but protects them from glucose dysregulation by attenuating insulin (show INS Proteins) resistance.

7. Its genotype showes an association with NAFLD, NASH (show SAMSN1 Proteins), fibrosis, and cirrhosis.

8. Individuals misusing alcohol who carry a particular variant of the gene PNPLA3 are more at risk of developing severe alcoholic hepatitis.

9. PNPLA3 is the first locus to be reproducibly and strongly associated with steatosis, fibrosis/cirrhosis in various liver diseases with different etiologies and even HCC (show FAM126A Proteins) in fatty liver diseases.

10. The associations between PNPLA3 rs738409 GG genotype and steatosis was significant and was associated to advanced fibrosis.

Mouse (Murine) Patatin-Like phospholipase Domain Containing 3 (PNPLA3) interaction partners

1. Histone acetylation plays a role in the modulation of PNPLA3 levels in the liver exposed to binge ethanol drinking.

2. Neither ablation nor overexpression of wild-type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M transgene causes steatosis.

3. PNPLA3 plays a role in remodeling TAG in lipid droplets, as they accumulate in response to food intake

4. adiponutrin/PNPLA3 is regulated by two key factors of the glycolytic and lipogenic pathways, raising the question of its implication in the metabolism of carbohydrates and lipids

5. data argue against a role for Pnpla3 loss-of-function in fatty liver disease or metabolic syndrome in mice.

6. Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin (show INS Proteins) resistance in mice.

7. Microarray-based gene profiling showed that the expression level of PNPLA3 in hepatocytes is correlated with that of genes associated with the lipogenic pathway such as ME1 (show ME1 Proteins), SPOT14 (show THRSP Proteins), and SCD1 (show SCD Proteins).

8. data suggest that murine ATGL (show PNPLA2 Proteins) but not adiponutrin contributes to net adipocyte lipolysis and that ATGL (show PNPLA2 Proteins) and adiponutrin are oppositely regulated by insulin (show INS Proteins) both in vitro and in vivo