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The protein encoded by PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. Additionally we are shipping PNPLA3 Antibodies (92) and PNPLA3 Kits (17) and many more products for this protein.
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Human PNPLA3 Protein expressed in Wheat germ - ABIN1315587
Winberg, Motlagh, Stenkula, Holm, Jones: Adiponutrin: a multimeric plasma protein. in Biochemical and biophysical research communications 2014
Meta-analysis provided strong and unequivocal evidence for a significant role for rs738409 in PNPLA3 in the progression of Alcohol-related Cirrhosis with effect sizes in the range expected for a relatively frequent single nuclear polymorphism in a complex disease.
PNPLA3 SNP I148M occurs with high frequency in Mexican population and favors development of NAFLD.
Overall, we showed that novel variants in PNPLA3 are very rare in our liver biopsy cohort, thereby indicating that their impact on the etiology of nonalcoholic fatty liver disease is probably limited. Nevertheless, for the three rare coding variants that were identified in patients with advanced liver disease, further functional characterization will be essential to verify their potential disease causality.
PNPLA3 GG genotype was elevated in aggressive disease phenotype of non-alcoholic fatty liver disease.
PNPLA3 was strongly expressed in the liver and clearly detectable in subcutaneous adipose tissue of obese patients. Weight loss induced by Laparoscopic gastric banding (LAGB) of severely obese patients led to significantly increased adipose, but not hepatic, tissue expression of PNPLA3. Weight loss induced by LAGB restored adipose tissue PNPLA3 expression which is suppressed by tumour necrosis factor alpha (show TNF Proteins).
Our study suggests that the pathogenic role of PNPLA3(148M) in nonalcoholic fatty liver disease is independent of the gene transcription in humans, which may be attributed to the high endogenous transcription level of PNPLA3 gene in human livers.
Children carrying the T allele of the MBOAT7 polymorphism had higher plasma alanine aminotransferase than the noncarriers; children with the MBOAT7, PNPLA3, and TM6SF2 variants had the highest plasma ALT
The association between the PNPLA3 variant and bipolar disorder may help guide further work on medication effectiveness, treatment options, prevention approaches, and understanding potential medication side effects among specific subgroups of individuals with the MM genotype.
The PNPLA3 rs738409 GG genotype is positively associated with hepatic steatosis in Asian patients with chronic hepatitis C.
The study proposes that polymorphisms in the PNPLA3 gene have highly predictive value in the development of nonalcoholic fatty liver disease and are independently associated with the severity of liver histology in patients with NAFLD.
Histone acetylation plays a role in the modulation of PNPLA3 levels in the liver exposed to binge ethanol drinking.
Neither ablation nor overexpression of wild-type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M transgene causes steatosis.
PNPLA3 plays a role in remodeling TAG in lipid droplets, as they accumulate in response to food intake
adiponutrin/PNPLA3 is regulated by two key factors of the glycolytic and lipogenic pathways, raising the question of its implication in the metabolism of carbohydrates and lipids
data argue against a role for Pnpla3 loss-of-function in fatty liver disease or metabolic syndrome in mice.
Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin (show INS Proteins) resistance in mice.
Microarray-based gene profiling showed that the expression level of PNPLA3 in hepatocytes is correlated with that of genes associated with the lipogenic pathway such as ME1 (show ME1 Proteins), SPOT14 (show THRSP Proteins), and SCD1 (show SCD Proteins).
data suggest that murine ATGL (show PNPLA2 Proteins) but not adiponutrin contributes to net adipocyte lipolysis and that ATGL (show PNPLA2 Proteins) and adiponutrin are oppositely regulated by insulin (show INS Proteins) both in vitro and in vivo
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.
, calcium-independent phospholipase A2-epsilon
, patatin-like phospholipase domain-containing protein 3