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PNPLA4 encodes a member of the patatin-like family of phospholipases. Additionally we are shipping PNPLA4 Proteins (3) and many more products for this protein.
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These results strongly suggest that PNPLA9 (show PLA2G6 Antibodies), -6 and -4 play a key role in GPL (show IL31RA Antibodies) turnover and homeostasis in human cells. A hypothetical model suggesting how these enzymes could recognize the relative concentration of the different GPLs is proposed
iPLA2epsilon (adiponutrin (show PNPLA3 Antibodies)), iPLA2zeta (TTS-2.2), and iPLA2eta (GS2) are three novel TAG lipases/acylglycerol transacylases that likely participate in TAG hydrolysis and the acyl-CoA (show GNPAT Antibodies) independent transacylation of acylglycerols
The GS2 (show RAB27A Antibodies) gene (PNPLA4) encodes a keratinocyte retinyl ester hydrolase (show CES1 Antibodies). The protein also catalyzes fatty acyl CoA (show GNPAT Antibodies)-dependent and -independent retinol esterification, using triolein as substrate and generates diacylglyceride and free fatty acid.
we report the identity of an inhibitor, TIP47 (show PLIN3 Antibodies), which prevents retinylester hydrolysis catalyzed by GS2 (show RAB27A Antibodies) lipase (show LIPG Antibodies) and hormone-sensitive lipase (show LIPE Antibodies)
GS2 promotes RE accumulation and may do so either as a catalyst or as a regulatory protein that enhances retinylesters formation catalyzed by other acyl transferases.
No association between genetic variants in PNPLA4 genes and childhood and adolescent obesity
This gene encodes a member of the patatin-like family of phospholipases. The encoded enzyme has both triacylglycerol lipase and transacylase activities and may be involved in adipocyte triglyceride homeostasis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome Y.
patatin-like phospholipase domain-containing protein 4
, patatin-like phospholipase 4
, patatin-like phospholipase domain containing 4
, IPLA2 eta
, calcium independent phospholipases A2 eta