anti-Paternally Expressed 10 (PEG10) Antibodies

Human Paternally Expressed 10 (PEG10) interaction partners

1. PEG10 expression is associated with advanced clinicopathological characteristics and can be used as a prognostic biomarker in patients with solid tumors.

2. Results demonstrated that an increased expression of PEG10 is associated vessel invasion, and the overall survival time of PC patients. E2F-1 (show E2F1 Antibodies) mediated PEG10 overexpression promotes pancreatic cancer (PC) cell proliferation via accelerating cell cycle progression and increase migration and invasion through ERK (show EPHB2 Antibodies)/MMP7 (show MMP7 Antibodies) pathway. These results suggest that PEG10 may serve as an oncogene (show RAB1A Antibodies) in PC pathogenesis.

3. miR (show MLXIP Antibodies)-122 suppresses PEG10 expression via direct binding to the 3'-UTR (show UTS2R Antibodies) of the PEG10 transcript.

4. PEG10 expression associates with the lymph node metastasis and overall survival of hepatocellular carcinoma patients.PEG10 expression level is essential for TGF-beta1 (show TGFB1 Antibodies) induced epithelialmesenchymal transition.

5. Knockdown of PEG10 expression by siRNA could lead to growth arrest and cell apoptosis in diffuse large B cell lymphoma cells in vitro.

6. PEG10 protein could be a potential biomarker predicting early recurrence and recurrence-free survival in HCC (show FAM126A Antibodies) patients after curative resection, even in those with normal serum alpha-fetoprotein (show AFP Antibodies) levels.

7. Study shows that expression level of PEG10 was significantly elevated in breast cancer tissues and associated with distant metastasis and poor clinical outcome and provides evidence that PEG10 is a crucial oncogene (show RAB1A Antibodies).

8. important role in trophoblast proliferation and promotes trophoblast invasion through TIMP-1 (show TIMP1 Antibodies)

9. Results revealed that PEG10 high expression was closely associated with the TNM (show ODZ1 Antibodies) classification in lung cancer and is a critical indicator for poor prognosis. Also, It promotes significantly proliferation, migration and invasion of A549 lung cancer cells.

10. The downregulated expression of the imprinted gene PEG10 may be an important reason for the occurrence of preeclampsia.

Mouse (Murine) Paternally Expressed 10 (PEG10) interaction partners

1. Loss of DNA methylation (show HELLS Antibodies) at the Peg10 imprinted gDMD associated with decreased embryonic viability and decreased labyrinthine volume.

2. Knockdown of Syncytin-A (show ERVW-1 Antibodies) demonstrated a functional regulation of cell-cell fusion, where knockdown of Peg10 showed no involvement in cell fusion

3. Programmed -1 ribosomal frameshifting in mouse and human Peg10 genes.

4. Peg10 gene is imprinted, with preferential expression from the paternal allele, and its deletion results in early embryonic lethality.

5. Results indicate that the induction of the imprinted gene paternally expressed 10 (PEG10) may play an important role during liver regeneration or carcinogenesis of the hepatocyte.

6. These findings strongly indicate that peg10 plays a crucial role at the immediate early (show JUN Antibodies) stage of adipocyte differentiation.

7. the ORF1 (show MED14 Antibodies)-2 protein of PEG10, synthesized utilizing the most efficient -1 frameshift mechanism yet documented in vivo, will have an essential function that is intrinsic to the importance of PEG10 in mammals

Cow (Bovine) Paternally Expressed 10 (PEG10) interaction partners

1. the abnormal DNA methylation (show HELLS Antibodies) epigenetic reprogramming of imprinting PEG10 gene in placenta may be one of the main causes of the abnormal development and death of the transgenic cloned cattle.

Pig (Porcine) Paternally Expressed 10 (PEG10) interaction partners

1. polymorphisms in PEG10 and PPP1R9A (show PPP1R9A Antibodies) were associated with fat deposition and carcass traits

2. The imprinting status of PEG10 is conserved in swine as paternal expression was demonstrated by quantitative allelic sequencing of reciprocal crosses in fetal tissues of whole brain, carcass, liver and placentae.

3. The expression patterns of PLAGL1 (show PLAGL1 Antibodies) and PEG10 genes in two breeds of swine are reported.