anti-Peptidyl Arginine Deiminase, Type IV (PADI4) Antibodies

PADI4 is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. Additionally we are shipping PADI4 Kits (16) and PADI4 Proteins (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PADI4 23569 Q9UM07
PADI4 18602 Q9Z183
PADI4 29512 O88807
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Top anti-PADI4 Antibodies at antibodies-online.com

Showing 10 out of 115 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: PADI4 Sample Type: 721_B Cell lysates Antibody Dilution: 1.0ug/ml  There is BioGPS gene expression data showing that PADI4 is expressed in 721_B 100 μL 2 to 3 Days
$319.00
Details
Human Goat Un-conjugated ELISA, IHC, WB ABIN185308 (0.3µg/ml) staining of human spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. HEK293 overexpressing PADI4 (RC206501) and probed with ABIN185308 (mock transfection in first lane), tested by Origene. 100 μg 6 to 7 Days
$429.84
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated FACS, WB 100 μL 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL 11 to 13 Days
$366.77
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$581.17
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of HepG2 cell lysate, using PADI4 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276948 staining HepG2? cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Details

Top referenced anti-PADI4 Antibodies

  1. Human Polyclonal PADI4 Primary Antibody for ELISA, WB - ABIN543481 : Barton, Bowes, Eyre, Spreckley, Hinks, John, Worthington: A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population. in Arthritis and rheumatism 2004 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal PADI4 Primary Antibody for ELISA, WB - ABIN250318 : Wang, Wysocka, Sayegh, Lee, Perlin, Leonelli, Sonbuchner, McDonald, Cook, Dou, Roeder, Clarke, Stallcup, Allis, Coonrod: Human PAD4 regulates histone arginine methylation levels via demethylimination. in Science (New York, N.Y.) 2004 (PubMed)
    Show all 2 Pubmed References

  3. Cow (Bovine) Polyclonal PADI4 Primary Antibody for WB - ABIN2785937 : Costenbader, Chang, De Vivo, Plenge, Karlson: Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking. in Arthritis research & therapy 2008 (PubMed)

  4. Human Polyclonal PADI4 Primary Antibody for ELISA, WB - ABIN546399 : Baka, Barta, Losonczy, Krenács, Pápay, Szarka, Sármay, Babos, Magyar, Géher, Buzás, Nagy: Specific expression of PAD4 and citrullinated proteins in lung cancer is not associated with anti-CCP antibody production. in International immunology 2011 (PubMed)

More Antibodies against PADI4 Interaction Partners

Human Peptidyl Arginine Deiminase, Type IV (PADI4) interaction partners

  1. Activation of PAD4 by membranolytic insults that result in high levels of intracellular calcium (higher than physiological neutrophil activation) leads to rapid citrullination of p47(phox)/NCF1 and p67(phox)/NCF2, as well as their dissociation from PAD4

  2. Required histone citrullination by PAD-4.

  3. these findings lead us to conclude that although PAD4 together with CR3-mediated ROS production is required for NET formation in response to A. fumigatus, PAD4-dependent NETosis is not required for A. fumigatus killing either in vitro or during infection.

  4. PADI4mediated EMT transition is proposed to represent a novel mechanism underlying the epigenetic and phenotypic alterations in lung cancer cells, and the PADI4 associated signaling pathway may be a therapeutic target for treating lung cancer in a clinical setting.

  5. High PADI4 expression is associated with esophageal squamous cell carcinoma tumor growth.

  6. these data argue against a major role for PAD4 in neutrophil extracellular trap formation, host defense, or organ injury during pneumonia-derived sepsis

  7. Chronic gingival inflammation is associated with increased local citrullination and PAD2 and PAD4 expression in periodontitis.

  8. Our findings suggest that PAD4-mediated RGG citrullination plays a key role in protein solubility and amyotrophic lateral sclerosis pathogenesis

  9. Study reveals the potential for PAD4-dependant citrullination to drive the progression of CRC liver metastasis.

  10. rs1635564 polymorphism is a candidate risk factor for systemic lupus erythematosus, particularly with renal involvement

  11. In most rheumatoid arthritis patients, PAD2 and PAD4 are equally efficient in generating citrullinated target sites for anti-citrullinated protein antibodies (ACPAs) in fibrinogen and ENO1. The binding of autoantibodies to histone H3 was generally higher after citrullination with PAD4 than with PAD2. Citrullinated human serum albumin is not a target for ACPAs.

  12. Molecular interplay between the dimer interface and the substrate-binding site of human PAD4 has been reported.

  13. PADI4 may be closely associated with hypoxiainduced autophagy, and the inhibition of hypoxiainduced autophagy by PADI4 knockdown may contribute to an increase in the apoptosis of RAFLS.

  14. MiRNA-146a rs2910164 and IRAK1 rs3027898 polymorphisms were a risk factor for predisposition to Rheumatoid Arthritis in Egyptian Population in codominant and dominant tested inheritance models, while, the miRNA-499 rs3746444 and PADI4 rs1748033 polymorphisms were a risk factor in codominant and recessive one.

  15. our meta-analysis demonstrated that the PADI4_94 polymorphisms might contribute to RA susceptibility especially in Asian populations but not in Caucasian populations.

  16. Meta-analysis indicated a significantly increased association between PADI -104C/T polymorphism and rheumatoid arthritis (RA) in Chinese and Japanese populations (which were the majority of included populations in the analysis).

  17. PADI4 interacted with SYVN1 directly and that overexpression of PADI4 suppressed the ubiquitination of proteins. Thus, a reduction in ER stress induced by PADI4 may abrogate the initiation of chronic RA by suppressing the proliferative signals of RA synoviocytes.

  18. mRNA expression of PADI2, PADI4 and Sp1 is upregulated in rheumatoid arthritis bone marrow CD34+ cells independently of the systemic inflammation or treatment regimen.

  19. this study in a Southern Mexican population suggests that PADI4 individual polymorphisms and the related susceptibility haplotype (GTG) are also genetic risk markers for rheumatoid arthritis

  20. The T allele of PADI4 rs2240340 is associated with Rheumatoid Arthritis in Asians.

Mouse (Murine) Peptidyl Arginine Deiminase, Type IV (PADI4) interaction partners

  1. Data suggest that mixed lineage kinase domain-like (MLKL) activation leads to loss of intracellular architecture and chromatin decondensation, but peptidylarginine deiminase 4 (PAD4) is only required for the externalization of neutrophil extracellular trap (NET).

  2. Our data support the notion that NETs promote atherosclerosis and that the use of specific PAD4 inhibitors may have therapeutic benefits in this potentially devastating condition.

  3. Renal proximal tubular PAD4 appears to contribute to ischemic acute kidney injury by promoting renal tubular apoptosis, whereas myeloid-cell PAD4 is preferentially involved in promoting neutrophil infiltration to the kidney and inflammation after renal ischemia/reperfusion.

  4. these findings lead us to conclude that although PAD4 together with CR3-mediated ROS production is required for NET formation in response to A. fumigatus, PAD4-dependent NETosis is not required for A. fumigatus killing either in vitro or during infection.

  5. these data argue against a major role for PAD4 in neutrophil extracellular trap formation, host defense, or organ injury during pneumonia-derived sepsis

  6. Our findings suggest that PAD4-mediated RGG citrullination plays a key role in protein solubility and amyotrophic lateral sclerosis pathogenesis

  7. Study reveals the potential for PAD4-dependant citrullination to drive the progression of CRC liver metastasis.

  8. PAD4 in neutrophils is essential for kidney NET formation and ischemic kidney injury.

  9. PADi4 is critical for neutrophil extracellular traps formation, but is dispensable for generalized citrullination

  10. sFlt-1 overexpression in Padi4(-/-) mice resulted in dramatically lower inflammatory and thrombotic response, which was accompanied by significant reduction in pregnancy losses. Inhibition of NETosis may serve as a novel target in disorders of impaired placentation.

  11. a role for NETs in cardiac fibrosis and conclude that PAD4 regulates age-related organ fibrosis and dysfunction.

  12. PADI4 exacerbates arthritis with diverse immunological modifications.

  13. Selective inhibition of peptidylarginine deiminase IV with Cl-amidine blocked NET formation, reduced atherosclerotic lesion area, and delayed time to carotid artery thrombosis in a photochemical injury model.

  14. Padi4 is part of the pluripotency transcriptional network, binding to regulatory elements of key stem-cell genes and activating their expression

  15. PAD4 regulates the proliferation of multipotent progenitors in the bone marrow by controlling c-myc expression.

  16. peptidyl-arginine deiminases inhibiion reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis.

  17. PAD4-mediated chromatin decondensation in the neutrophil is crucial for pathological venous thrombosis and present neutrophil activation and PAD4 as potential drug targets for deep vein thrombosis.

  18. PAD4 is dispensable in this effector phase model of arthritis

  19. analysis of regulation of histone modification and chromatin structure by the p53-PADI4 pathway

  20. An increase in citrullinated proteins resulting from increased PAD2 and 4 is an important change in the pathogenesis of multiple sclerosis.

PADI4 Antigen Profile

Protein Summary

This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.

Gene names and symbols associated with PADI4

  • peptidyl arginine deiminase 4 (PADI4) antibody
  • peptidyl arginine deiminase, type IV (Padi4) antibody
  • peptidyl arginine deiminase 4 (Padi4) antibody
  • PAD antibody
  • Pad4 antibody
  • PADI5 antibody
  • Pdi4 antibody
  • PDI5 antibody

Protein level used designations for PADI4

peptidyl arginine deiminase, type IV , protein-arginine deiminase type-4-like , HL-60 PAD , PADI-H protein , peptidyl arginine deiminase, type V , protein-arginine deiminase type IV , protein-arginine deiminase type-4 , PAD type IV , peptidylarginine deiminase IV , PAD-R4 , peptidyl arginine deiminase, type 4 , peptidylarginine deiminase type alpha

GENE ID SPECIES
100026011 Monodelphis domestica
100049826 Equus caballus
100415489 Callithrix jacchus
100471129 Ailuropoda melanoleuca
100592291 Nomascus leucogenys
23569 Homo sapiens
18602 Mus musculus
456530 Pan troglodytes
29512 Rattus norvegicus
606921 Canis lupus familiaris
508161 Bos taurus
100524749 Sus scrofa
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