PAD4 antibody (AA 1-250)

Catalog No. ABIN7166400

Product Details anti-PAD4 Antibody

Target: PAD4 (PADI4) (Peptidyl Arginine Deiminase, Type IV (PADI4))

Binding Specificity: AA 1-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAD4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Protein-arginine deiminase type-4 protein (1-250AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PAD4

Target: PAD4 (PADI4) (Peptidyl Arginine Deiminase, Type IV (PADI4))

Alternative Name: PADI4 (PADI4 Products)

Synonyms: PAD antibody, PAD4 antibody, PADI5 antibody, PDI4 antibody, PDI5 antibody, Pad4 antibody, Pdi4 antibody, peptidyl arginine deiminase 4 antibody, peptidyl arginine deiminase, type IV antibody, PADI4 antibody, Padi4 antibody

Background:

Background: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at \\\'Arg-54\\\' (to form H1R54ci), histone H3 at \\\'Arg-2\\\', \\\'Arg-8\\\', \\\'Arg-17\\\' and/or \\\'Arg-26\\\' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at \\\'Arg-3\\\' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of \\\'Arg-54\\\' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at \\\'Arg-2142\\\', which favors its interaction with NCOA2/GRIP1.

Aliases: EC 3.5.3.15 antibody, HL 60 PAD antibody, HL-60 PAD antibody, PAD 4 antibody, PAD antibody, PADI 4 antibody, PADI 5 antibody, PADI H protein antibody, Padi4 antibody, PADI4_HUMAN antibody, PADI5 antibody, PDI 4 antibody, PDI 5 antibody, PDI4 antibody, PDI5 antibody, Peptidyl arginine deiminase type IV antibody, Peptidyl arginine deiminase type V antibody, Peptidylarginine deiminase IV antibody, Protein arginine deiminase antibody, Protein arginine deiminase type 4 antibody, Protein arginine deiminase type IV antibody, Protein-arginine deiminase type IV antibody, Protein-arginine deiminase type-4 antibody

UniProt: Q9UM07