Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) ELISA Kits

PPIA encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. Additionally we are shipping PPIA Antibodies (242) and PPIA Proteins (58) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PPIA 5478 P62937
PPIA 25518 P10111
PPIA 268373 P17742
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Top PPIA ELISA Kits at

Showing 10 out of 80 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.49 ng/mL 1.25 ng/mL - 80 ng/mL Typical standard curve SDS-PAGE of Protein Standard from the Kit (Highly purified E. coli-expressed recombinant human CYPA). 96 Tests Log in to see 12 to 14 Days
Mouse 0.64 ng/mL 1.56 ng/mL - 100 ng/mL 96 Tests Log in to see 13 to 16 Days
Rat 31.25 pg/mL 125-8000 pg/mL Typical standard curve 96 Tests Log in to see 13 to 16 Days
Rabbit 1.0 pg/mL 250-5000 pg/mL   96 Tests Log in to see 15 to 18 Days
Guinea Pig 1.0 pg/mL 250-5000 pg/mL   96 Tests Log in to see 15 to 18 Days
Chicken 28.125 ng/mL 46.875-3000 ng/mL   96 Tests Log in to see 12 to 14 Days
Pig 0.75 ng/mL 1.25-80 ng/mL   96 Tests Log in to see 12 to 14 Days
Monkey 1.0 5.0   96 Tests Log in to see 15 to 18 Days
Dog 1.0 pg/mL 250-5000 pg/mL   96 Tests Log in to see 15 to 18 Days
  96 Tests Log in to see 15 to 18 Days

Top referenced PPIA ELISA Kits

  1. Human PPIA ELISA Kit for Sandwich ELISA - ABIN414744 : Seizer, Schönberger, Schött, Lang, Langer, Bigalke, Krämer, Borst, Daub, Heidenreich, Schmidt, Lindemann, Herouy, Gawaz, May: EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. in Atherosclerosis 2010 (PubMed)
    Show all 8 Pubmed References

  2. Human PPIA ELISA Kit for Sandwich ELISA - ABIN6574244 : Chang, Su, Chang, Lee, Kuo, Huang, Tseng, Liu: Cyclophilin-A: a novel biomarker for untreated male essential hypertension. in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2013 (PubMed)
    Show all 8 Pubmed References

  3. Mouse (Murine) PPIA ELISA Kit for Sandwich ELISA - ABIN415460 : Perrucci, Straino, Corlianò, Scopece, Napolitano, Berk, Lombardi, Pompilio, Capogrossi, Nigro: Cyclophilin A modulates bone marrow-derived CD117(+) cells and enhances ischemia-induced angiogenesis via the SDF-1/CXCR4 axis. in International journal of cardiology 2016 (PubMed)
    Show all 2 Pubmed References

  4. Rat (Rattus) PPIA ELISA Kit for Sandwich ELISA - ABIN578507 : Tang, Wang, Ma, Guan, Pan, Yao, Chen, Li, Yang, Zhu, Tu: Simvastatin attenuated rat thoracic aorta remodeling by decreasing ROCK2‑mediated CyPA secretion and CD147‑ERK1/2‑cyclin pathway. in Molecular medicine reports 2018 (PubMed)

  5. Human PPIA ELISA Kit for Sandwich ELISA - ABIN365081 : Satoh, Fukumoto, Sugimura, Miura, Aoki, Nochioka, Tatebe, Miyamichi-Yamamoto, Shimizu, Osaki, Takagi, Tsuburaya, Ito, Matsumoto, Nakayama, Takeda, Takahashi, Ito, Yasuda, Shimokawa: Plasma cyclophilin A is a novel biomarker for coronary artery disease. in Circulation journal : official journal of the Japanese Circulation Society 2013 (PubMed)

  6. Mouse (Murine) PPIA ELISA Kit for Sandwich ELISA - ABIN366417 : Song, Yang, Chen, Huang, Yin, He, Huang, Hu: Prognosis of sepsis induced by cecal ligation and puncture in mice improved by anti-Clonorchis Sinensis cyclopholin a antibodies. in Parasites & vectors 2015 (PubMed)

  7. Mouse (Murine) PPIA ELISA Kit for Sandwich ELISA - ABIN1114491 : Choi, Suh, Rhee, Oh, Kim, Pak, Choe, Ha, Chon: Exposure to tetrabromobisphenol A induces cellular dysfunction in osteoblastic MC3T3-E1 cells. in Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 2017 (PubMed)

More ELISA Kits for PPIA Interaction Partners

Xenopus laevis Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

  1. Over-expression leads to an expansion and disorganisation of the neural crest domain.

Human Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

  1. Plasma CyP A and CD147 can serve as indicators of renal disease progression in type 2 diabetes patients

  2. The CypA genetic polymorphisms of rs3735481 and rs9638978 may be associated with severe PE, and rs9638978 AA genotype may be associated with an increasing risk of early onset severe PE in Han Chinese women. High CypA levels in serum and placenta may contribute to the pathogenesis of severe PE.

  3. The model is consistent with experimental data also from previous works and supports the concept that the peptide does not interfere with other CypA activities unrelated to AIF activation; therefore, it may serve as an ideal template for generating future non-peptidic antagonists.

  4. our findings reveal a novel ubiquitination-based mechanism by which CypA regulates the replication of influenza A virus.

  5. Molecular structure of cyclophilin A in complex with alispovir has been presented.

  6. Cyclophilin A is required for HIV-1 Tat palmitoylation .

  7. These results suggested that the CyPA located on SV-HUC-1 cell membranes may be the potential receptor of Mycoplasma genitalium adhesion protein (MgPa), which could provide an experimental basis for elucidating the function of MgPa and the possible pathogenic mechanism of M. genitalium.

  8. increased serum cyclophilin A concentrations could reflect trauma severity and unfavorable outcome after head trauma, substantializing cyclophilin A as a potential biomarker for prognostic prediction of TBI

  9. Here, the binding site of AIF(Delta1-121) and AIF(370-394) on CypA has been mapped by NMR spectroscopy and biochemical studies, and a molecular model of the complex has been proposed. The authors show that AIF(370-394) interacts with CypA on the same surface recognized by AIF(Delta1-121) protein and that the region is very close to the CypA catalytic pocket.

  10. CyPA was significantly increased in convalescent COPD patients and further elevated in COPD patients with acute exacerbation.

  11. CypA expression was not an independent prognostic factor, but correlated with poor prognosis of lung adenocarcinoma

  12. Extracellular cyclophilin A augments platelet-dependent thrombosis and thromboinflammation.

  13. the increased expression of CyPA in ectopic endometrial tissue is associated with endometrioma recurrences and vascularity.

  14. Taken together, these findings reveal an essential role of CypA in boosting RIG-I-mediated antiviral immune responses by controlling the ubiquitination of RIG-I and MAVS.

  15. Data show that cyclophilin A (CypA) is up-regulated in oral squamous cell carcinoma (OSCC) arising from oral submucous fibrosis (OSF).

  16. K308 of NS5A is indispensable for both RNA and NS5B binding, whereas W316 is essential for protein-protein interactions with CypA and NS5B.

  17. PPIA is differentially expressed in lesional biopsy specimens from patients with atopic eczema relative to normal skin

  18. inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) is an intracellular target of the PPIA-Sanglifehrin A binary complex.

  19. these data suggest that CypA-NS4B interaction regulates Yellow fever virus (YFV )replication. Finally, we present the first evidence that YFV inhibition may depend on NS4B-CypA interaction.

  20. This report reviews the literature related to the mechanism of CypA-dependent cytokine secretion and discusses this factor as a possible therapeutic target in inflammatory diseases.

Mouse (Murine) Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

  1. Extracellular cyclophilin A augments platelet-dependent thrombosis and thromboinflammation.

  2. Endothelial cell-derived CypA (especially AcK-CypA) causes pulmonary artery hypertension by a presumptive mechanism involving increased EC apoptosis, inflammation, and oxidative stress.

  3. ox-LDL-induced CyPA secretion requires vesicle transportation, actin remodeling and ROCK-dependent diphosphorylation of myosin light chains in vascular smooth muscle cells.

  4. knockdown of CD147 on Hepa1-6 cells resulted in significantly increased T cells chemotaxis induced by CypA both in vivo and in vitro.

  5. CypA dually exerts pro-osteogenic and anti-osteoclastic effects.

  6. Extracellular CyPA activates platelets via cluster of differentiation 147-mediated phosphoinositid-3-kinase/Akt-signaling, leading to enhanced adhesion and thrombus formation independently of intracellular CyPA.

  7. CypA provided stability for NF-kappaB p65 and promoted NF-kappaB p65 nuclear translocation, resulting in increased nuclear accumulation and enhanced NF-kappaB activity.

  8. Newborn CypA-deficient pups exhibited generalized, pronounced skeletal defects, while high-resolution micro-computed tomography analyses of the femurs and lumbar vertebrae revealed delayed or incomplete endochondral ossification.

  9. Cyclophilin A secretion was increased in lymphocytes from atherogenic mice.

  10. CD137-CD137L interactions mediated via regulation of CyPA contribute to the progression of atherosclerosis.

  11. Reactive oxygen species-dependent CypA secretion by endothelial cells is an important signaling mechanism through which endothelial cell reactive oxygen species regulate susceptibility of structural components of the aortic wall to aortic dissection.

  12. CyPA is an important regulator for AngII-induced ROS generation in VSMC through interaction with p47phox and cell cytoskeleton, which enhances the translocation of p47phox to caveolae.

  13. CYPA was identified as a novel host restriction factor that confered protection against rotavirus infection.

  14. CyPA expression increases and may modulate inflammatory cell adhesion and interleukin-6 expression inducing vascular smooth muscle cell migration and inflammatory cell extravasation in a time-dependent manner

  15. How does oxidative stress contribute to vascular disease? Data from vascular smooth muscle suggest that reduced glutathione peroxidase 1 (i.e., oxidative stress) promotes secretion of CypA which mediates paracrine inflammation of vasculature.

  16. CsA inhibits BKV replication through CypA and NFAT, which may be potential targets of anti-BKV treatment

  17. CyPA is an important Ca(2+) regulator in platelets, a critical mechanism for arterial thrombosis.

  18. CypA is a key target for treating APOE4-mediated neurovascular injury and the resulting neuronal dysfunction and degeneration

  19. truncated CyPA detected in brain following prion infection may have an important role in the activation of brain-derived primary astroglia and microglia in prion disease and perhaps other neurodegenerative or neuroinflammatory diseases.

  20. Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion.

PPIA Antigen Profile

Antigen Summary

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.

Gene names and symbols associated with PPIA

  • peptidylprolyl isomerase A (PPIA) antibody
  • peptidylprolyl isomerase Aa (cyclophilin A) (ppiaa) antibody
  • peptidylprolyl isomerase A (cyclophilin A) L homeolog (ppia.L) antibody
  • cyclophilin A (Cypa) antibody
  • cyclophilin A (CNB01230) antibody
  • cyclophilin A (CNB01290) antibody
  • cyclophilin A (Tc00.1047053506925.300) antibody
  • cyclophilin A (Tb11.03.0250) antibody
  • cyclophilin a (CYPA) antibody
  • peptidylprolyl isomerase A (cyclophilin A) (Ppia) antibody
  • peptidylprolyl isomerase A (cyclophilin A) (ppia) antibody
  • peptidylprolyl isomerase A (Ppia) antibody
  • peptidylprolyl isomerase A (cyclophilin A) (PPIA) antibody
  • 2700098C05 antibody
  • Cphn antibody
  • CYCA antibody
  • CyP-18 antibody
  • CyP-A antibody
  • Cyp1 antibody
  • cypA antibody
  • CYPH antibody
  • fa93g09 antibody
  • MGC75715 antibody
  • MT-ND1 antibody
  • MTND1 antibody
  • NADH1 antibody
  • ND1 antibody
  • ppia antibody
  • PPIA-2 antibody
  • PPIase A antibody
  • wu:fa93g09 antibody
  • wu:fb05e11 antibody
  • wu:fb13h02 antibody
  • wu:fb15a05 antibody

Protein level used designations for PPIA

PPIase A , cyclophilin A , cyclophilin T , cyclophilin T-cell , cyclosporin A-binding protein , peptidyl-prolyl cis-trans isomerase A , rotamase A , 2-peptidylprolyl isomerase A , peptidylprolyl isomerase A (cyclophilin A) , cyclophilin 18 , immunophilin , cyclophilin-like , T cell cyclophilin , cyclophilin , cyclophilin a , p1B15 , p31 , Cyclophilin A , Cyclosporin A-binding protein , Rotamase A , SP18 , NADH dehydrogenase subunit 1 , NADH-ubiquinone oxidoreductase chain 1 , Peptidyl-prolyl cis-trans isomerase A

281418 Bos taurus
336612 Danio rerio
100008724 Oryctolagus cuniculus
397637 Sus scrofa
463386 Pan troglodytes
398630 Xenopus laevis
692737 Bombyx mori
574102 Macaca mulatta
5478 Homo sapiens
3255869 Cryptococcus neoformans var. neoformans JEC21
3255972 Cryptococcus neoformans var. neoformans JEC21
3554513 Trypanosoma cruzi strain CL Brener
3664945 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5652501 Leishmania major strain Friedlin
25518 Rattus norvegicus
394470 Xenopus (Silurana) tropicalis
100594480 Nomascus leucogenys
268373 Mus musculus
776282 Gallus gallus
608151 Canis lupus familiaris
100173012 Pongo abelii
493966 Felis catus
443258 Ovis aries
100973085 Pan paniscus
100722609 Cavia porcellus
100769490 Cricetulus griseus
101925040 Macaca fascicularis
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