Peptidylprolyl Isomerase A (Cyclophilin A) Proteins (PPIA)

PPIA encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. Additionally we are shipping PPIA Antibodies (245) and PPIA Kits (79) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPIA 5478 P62937
PPIA 25518 P10111
PPIA 268373 P17742
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Top PPIA Proteins at

Showing 10 out of 59 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Escherichia coli (E. coli) Human Un-conjugated 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-GST serum (WB) and peptide fingerprinting by MALDI-TOF-TOF mass spectrometry 50 μg Log in to see 6 to 9 Days
Escherichia coli (E. coli) Human GST tag Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) (AA 2-165), (full length) protein (GST tag) 1 mg Log in to see 60 to 71 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 14 to 16 Days
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 14 to 16 Days
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human Cyclophilin A Protein. 100 μg Log in to see 11 to 18 Days

PPIA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus) ,

Mouse (Murine)

Top referenced PPIA Proteins

  1. Human PPIA Protein expressed in Wheat germ - ABIN1315865 : He, Wang, Srinivasan, Xu, Padilla, Li, Wang, Liu, Gou, Shen, Xing, Lin: A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. in Oncogene 2014 (PubMed)
    Show all 2 Pubmed References

More Proteins for Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) Interaction Partners

Xenopus laevis Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

  1. Over-expression leads to an expansion and disorganisation of the neural crest domain.

Human Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

  1. Molecular structure of cyclophilin A in complex with alispovir has been presented.

  2. Cyclophilin A is required for HIV-1 Tat palmitoylation .

  3. These results suggested that the CyPA located on SV-HUC-1 cell membranes may be the potential receptor of Mycoplasma genitalium adhesion protein (MgPa), which could provide an experimental basis for elucidating the function of MgPa and the possible pathogenic mechanism of M. genitalium.

  4. increased serum cyclophilin A concentrations could reflect trauma severity and unfavorable outcome after head trauma, substantializing cyclophilin A as a potential biomarker for prognostic prediction of TBI

  5. Here, the binding site of AIF(Delta1-121) and AIF(370-394) on CypA has been mapped by NMR spectroscopy and biochemical studies, and a molecular model of the complex has been proposed. The authors show that AIF(370-394) interacts with CypA on the same surface recognized by AIF(Delta1-121) protein and that the region is very close to the CypA catalytic pocket.

  6. CyPA was significantly increased in convalescent COPD patients and further elevated in COPD patients with acute exacerbation.

  7. CypA expression was not an independent prognostic factor, but correlated with poor prognosis of lung adenocarcinoma

  8. Extracellular cyclophilin A augments platelet-dependent thrombosis and thromboinflammation.

  9. the increased expression of CyPA in ectopic endometrial tissue is associated with endometrioma recurrences and vascularity.

  10. Taken together, these findings reveal an essential role of CypA in boosting RIG-I-mediated antiviral immune responses by controlling the ubiquitination of RIG-I and MAVS.

  11. Data show that cyclophilin A (CypA) is up-regulated in oral squamous cell carcinoma (OSCC) arising from oral submucous fibrosis (OSF).

  12. K308 of NS5A is indispensable for both RNA and NS5B binding, whereas W316 is essential for protein-protein interactions with CypA and NS5B.

  13. PPIA is differentially expressed in lesional biopsy specimens from patients with atopic eczema relative to normal skin

  14. inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) is an intracellular target of the PPIA-Sanglifehrin A binary complex.

  15. these data suggest that CypA-NS4B interaction regulates Yellow fever virus (YFV )replication. Finally, we present the first evidence that YFV inhibition may depend on NS4B-CypA interaction.

  16. This report reviews the literature related to the mechanism of CypA-dependent cytokine secretion and discusses this factor as a possible therapeutic target in inflammatory diseases.

  17. Networks of dynamic allostery regulate cyclophilin A function.

  18. Results show that CypA is overexpressed in human hepatocellular carcinoma (HCC) and is associated with TNM stage and suggest that CypA may be involved in the development and progression of HCC.

  19. Plasma CyPA levels can be used to predict all-cause death, rehospitalization, and coronary revascularization in patients with coronary artery disease.

  20. data suggest that rs6850 G SNP enhances HIV-1 replication through upregulation of CypA expression following HIV-1 infection

Mouse (Murine) Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

  1. Extracellular cyclophilin A augments platelet-dependent thrombosis and thromboinflammation.

  2. Endothelial cell-derived CypA (especially AcK-CypA) causes pulmonary artery hypertension by a presumptive mechanism involving increased EC apoptosis, inflammation, and oxidative stress.

  3. ox-LDL-induced CyPA secretion requires vesicle transportation, actin remodeling and ROCK-dependent diphosphorylation of myosin light chains in vascular smooth muscle cells.

  4. knockdown of CD147 on Hepa1-6 cells resulted in significantly increased T cells chemotaxis induced by CypA both in vivo and in vitro.

  5. CypA dually exerts pro-osteogenic and anti-osteoclastic effects.

  6. Extracellular CyPA activates platelets via cluster of differentiation 147-mediated phosphoinositid-3-kinase/Akt-signaling, leading to enhanced adhesion and thrombus formation independently of intracellular CyPA.

  7. CypA provided stability for NF-kappaB p65 and promoted NF-kappaB p65 nuclear translocation, resulting in increased nuclear accumulation and enhanced NF-kappaB activity.

  8. Newborn CypA-deficient pups exhibited generalized, pronounced skeletal defects, while high-resolution micro-computed tomography analyses of the femurs and lumbar vertebrae revealed delayed or incomplete endochondral ossification.

  9. Cyclophilin A secretion was increased in lymphocytes from atherogenic mice.

  10. CD137-CD137L interactions mediated via regulation of CyPA contribute to the progression of atherosclerosis.

  11. Reactive oxygen species-dependent CypA secretion by endothelial cells is an important signaling mechanism through which endothelial cell reactive oxygen species regulate susceptibility of structural components of the aortic wall to aortic dissection.

  12. CyPA is an important regulator for AngII-induced ROS generation in VSMC through interaction with p47phox and cell cytoskeleton, which enhances the translocation of p47phox to caveolae.

  13. CYPA was identified as a novel host restriction factor that confered protection against rotavirus infection.

  14. CyPA expression increases and may modulate inflammatory cell adhesion and interleukin-6 expression inducing vascular smooth muscle cell migration and inflammatory cell extravasation in a time-dependent manner

  15. How does oxidative stress contribute to vascular disease? Data from vascular smooth muscle suggest that reduced glutathione peroxidase 1 (i.e., oxidative stress) promotes secretion of CypA which mediates paracrine inflammation of vasculature.

  16. CsA inhibits BKV replication through CypA and NFAT, which may be potential targets of anti-BKV treatment

  17. CyPA is an important Ca(2+) regulator in platelets, a critical mechanism for arterial thrombosis.

  18. CypA is a key target for treating APOE4-mediated neurovascular injury and the resulting neuronal dysfunction and degeneration

  19. truncated CyPA detected in brain following prion infection may have an important role in the activation of brain-derived primary astroglia and microglia in prion disease and perhaps other neurodegenerative or neuroinflammatory diseases.

  20. Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion.

PPIA Protein Profile

Protein Summary

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.

Gene names and symbols associated with PPIA

  • peptidylprolyl isomerase A (PPIA)
  • peptidylprolyl isomerase Aa (cyclophilin A) (ppiaa)
  • peptidylprolyl isomerase A (cyclophilin A) L homeolog (ppia.L)
  • cyclophilin A (Cypa)
  • cyclophilin A (CNB01230)
  • cyclophilin A (CNB01290)
  • cyclophilin A (Tc00.1047053506925.300)
  • cyclophilin A (Tb11.03.0250)
  • cyclophilin a (CYPA)
  • peptidylprolyl isomerase A (cyclophilin A) (Ppia)
  • peptidylprolyl isomerase A (cyclophilin A) (ppia)
  • peptidylprolyl isomerase A (Ppia)
  • peptidylprolyl isomerase A (cyclophilin A) (PPIA)
  • 2700098C05 protein
  • Cphn protein
  • CYCA protein
  • CyP-18 protein
  • CyP-A protein
  • Cyp1 protein
  • cypA protein
  • CYPH protein
  • fa93g09 protein
  • MGC75715 protein
  • MT-ND1 protein
  • MTND1 protein
  • NADH1 protein
  • ND1 protein
  • ppia protein
  • PPIA-2 protein
  • PPIase A protein
  • wu:fa93g09 protein
  • wu:fb05e11 protein
  • wu:fb13h02 protein
  • wu:fb15a05 protein

Protein level used designations for PPIA

PPIase A , cyclophilin A , cyclophilin T , cyclophilin T-cell , cyclosporin A-binding protein , peptidyl-prolyl cis-trans isomerase A , rotamase A , 2-peptidylprolyl isomerase A , peptidylprolyl isomerase A (cyclophilin A) , cyclophilin 18 , immunophilin , cyclophilin-like , T cell cyclophilin , cyclophilin , cyclophilin a , p1B15 , p31 , Cyclophilin A , Cyclosporin A-binding protein , Rotamase A , SP18 , NADH dehydrogenase subunit 1 , NADH-ubiquinone oxidoreductase chain 1 , Peptidyl-prolyl cis-trans isomerase A

281418 Bos taurus
336612 Danio rerio
100008724 Oryctolagus cuniculus
397637 Sus scrofa
463386 Pan troglodytes
398630 Xenopus laevis
692737 Bombyx mori
574102 Macaca mulatta
5478 Homo sapiens
3255869 Cryptococcus neoformans var. neoformans JEC21
3255972 Cryptococcus neoformans var. neoformans JEC21
3554513 Trypanosoma cruzi strain CL Brener
3664945 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5652501 Leishmania major strain Friedlin
25518 Rattus norvegicus
394470 Xenopus (Silurana) tropicalis
100594480 Nomascus leucogenys
268373 Mus musculus
776282 Gallus gallus
608151 Canis lupus familiaris
100173012 Pongo abelii
493966 Felis catus
443258 Ovis aries
100973085 Pan paniscus
100722609 Cavia porcellus
100769490 Cricetulus griseus
101925040 Macaca fascicularis
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