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The protein encoded by PPL is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. Additionally we are shipping Periplakin Antibodies (50) and Periplakin Proteins (6) and many more products for this protein.
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The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
, 190 kDa paraneoplastic pemphigus antigen
, 195 kDa cornified envelope precursor protein
, 195kDa protein