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Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 [PubMed 10441517]). Additionally we are shipping PXDN Kits (15) and PXDN Proteins (9) and many more products for this protein.
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Results show that PXDN expression decreases with TGF-beta1 (show TGFB1 Antibodies) treatment in cervical carcinoma cell lines, and is regulated by the EMT (show ITK Antibodies) master transcription factor Snai1 (show SNAI1 Antibodies). This implicates PXDN in cancer development and processes that involve EMT (show ITK Antibodies).
Data suggest that VPO1 contributes to oxidation and retention of LDL in vessel walls, and formation foam cells, indicating VPO1 as a novel potential mediator of atherosclerosis.
VPO1 plays a critical role in asymmetric dimethylarginine production via H2O2-VPO1-hypochlorous acid pathways, which may contribute to endothelial dysfunction in hypertension.
PC processing of Pxdn is a key regulatory step that contributes to its function and, therefore, supports BM integrity and homeostasis.
PXDN expression is significantly upregulated in human masticatory mucosa during wound healing
Novel mutations in PXDN cause microphthalmia and anterior segment dysgenesis
Despite sequence homology at the active site and biophysical properties similar to human peroxidases, the catalytic efficiency of bromide oxidation (kcat/KM(app (show APP Antibodies))) of full-length hsPxd01 is rather low but increased upon truncation.
MiR (show MLXIP Antibodies)-4782-3p inhibited cell proliferation in NSCLC by targeting USP14, ZEB2 (show ZEB2 Antibodies) and XIAP (show XIAP Antibodies).
studies demonstrate the enzymatic properties and substrate specificity of VPO1 are similar to MPO (show MPO Antibodies); however, significantly lower catalytic rate constants of VPO1 relative to MPO (show MPO Antibodies) suggest the possibility of other physiologic roles for this peroxidase
VPO1 is likely to participate in host defense, with bactericidal activity mediated through the generation of HOCl.
Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit (Col4a1 (show COL4A1 Antibodies), GPBP (show COL4A3BP Antibodies), Lamc1 (show LAMC1 Antibodies), peroxidasin) during uterine reprogramming.
Cdkn1b (show CDKN1B Antibodies) exert its effects via the inhibition of proliferation and is mediated by miR (show MLXIP Antibodies)-24 and targeted by the transcription factors FOXO4 (show FOXO4 Antibodies) and AP4 (show REPIN1 Antibodies) in the peroxidasin (Pxdn) mutation-induced eye disorders, such as glaucoma.
Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999
melanoma-associated antigen MG50
, p53-responsive gene 2 protein
, peroxidasin homolog
, vascular peroxidase 1