anti-Peroxiredoxin 6 (PRDX6) Antibodies

The protein encoded by PRDX6 is a member of the thiol-specific antioxidant protein family.

list all antibodies Gene Name GeneID UniProt
Anti-Human PRDX6 PRDX6 9588 P30041
Anti-Mouse PRDX6 PRDX6 11758 O08709
Anti-Rat PRDX6 PRDX6 94167 O35244
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Top anti-Peroxiredoxin 6 Antibodies at antibodies-online.com

Showing 10 out of 189 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-PRDX6 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PRDX6 Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate PRDX6 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells Host:  Rat  Target Name:  PRDX6  Sample Tissue:  Rat Liver  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- Peroxiredoxin 6 Picoband antibody, Western blotting All lanes: Anti Peroxiredoxin 6  at 0.5ug/ml Lane 1: Mouse Liver Tissue Lysate at 50ug Lane 2: 293T Whole Cell Lysate at 40ug Predicted bind size: 25KD Observed bind size: 25KD IHC(P): Human Mammary Cancer Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB PRDX6 Antibody (Center) (ABIN650765) western blot analysis in 293 cell line lysates (35 µg/lane).This demonstrates the PRDX6 antibody detected the PRDX6 protein (arrow). PRDX6 Antibody (Center) (ABIN650765) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western Blot: Peroxiredoxin 6 Antibody [NBP1-55159] - HepG2 cell lysate, concentration 1.25ug/ml. 100 μL Log in to see 8 to 11 Days
$444.19
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: Peroxiredoxin 6 Antibody [NBP1-90332] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue.Lane 6: Human tonsil tissue Immunohistochemistry-Paraffin: Peroxiredoxin 6 Antibody [NBP1-90332] - Staining of human stomach shows strong nuclear and cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of PRDX6 Antibody (C-term) (ABIN389471) in CEM cell line lysates (35 µg/lane). PRDX6 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of PRDX6 (arrow) using rabbit polyclonal PRDX6 Antibody (C-term) (ABIN389471). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PRDX6 gene (Lane 2) . 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$727.83
Details
Human Mouse Un-conjugated ELISA, WB PRDX6 monoclonal antibody (M01), clone S1. Western Blot analysis of PRDX6 expression in MCF-7. PRDX6 monoclonal antibody (M01), clone 3A10-2A11. Western Blot analysis of PRDX6 expression in human liver. 100 μg Log in to see 11 to 12 Days
$440.00
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details

Top referenced anti-Peroxiredoxin 6 Antibodies

  1. Human Monoclonal Peroxiredoxin 6 Primary Antibody for ELISA, WB - ABIN564140 : Jia, Veiseth-Kent, Grove, Kuziora, Aass, Hildrum, Hollung: Peroxiredoxin-6--a potential protein marker for meat tenderness in bovine longissimus thoracis muscle. in Journal of animal science 2009 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal Peroxiredoxin 6 Primary Antibody for IHC, IHC (p) - ABIN4344944 : Dammeyer, Arnér: Human Protein Atlas of redox systems - what can be learnt? in Biochimica et biophysica acta 2010 (PubMed)

  3. Human Polyclonal Peroxiredoxin 6 Primary Antibody for WB - ABIN4344942 : Hossain, De Souza, Bagul, MacPhee, Kessaris, Morsy: HSP70, Peroxiredoxin-3 and -6 are upregulated during renal warm ischaemia in a donation after circulatory death model. in Journal of proteomics 2014 (PubMed)

More Antibodies against Peroxiredoxin 6 Interaction Partners

Human Peroxiredoxin 6 (PRDX6) interaction partners

  1. The present data suggest that PS2 (show PSEN2 Antibodies) mutations suppress lung tumor development by inhibiting the iPLA2 (show PLA2G6 Antibodies) activity of PRDX6 via a gamma-secretase cleavage mechanism and may explain the inverse relationship between lung cancer and Alzheimer's disease incidence.

  2. The increased HDL (show HSD11B1 Antibodies) and plasma levels of PRDX6 in AAA (show APP Antibodies) patients support the potential of PRDX6 as a new biomarker of AAA (show APP Antibodies).

  3. These observations demonstrated that the expression and localization of NPM (show NPM1 Antibodies) affected the homeostatic balance of oxidative stress in tumor cells via PRDX6 protein. The regulation axis of NPM (show NPM1 Antibodies)/PRDX/ROS (show ROS1 Antibodies) may provide a novel therapeutic target for cancer treatment.

  4. the transition-state substrate analogue inhibitor of Prdx6 phospholipase A2 activity (MJ-33) was shown to suppress Nox1 activity, suggesting Nox1 activity is regulated by the phospholipase activity of Prdx6. Finally, wild type Prdx6, but not lipase or peroxidase mutant forms, supports Nox1-mediated cell migration in the HCT-116 colon epithelial cell model of wound closure

  5. The constitutive elevations of Prdx6 and NF-kappaB (show NFKB1 Antibodies) during Clonorchis sinensis infection may be associated with more severe persistent hepatobiliary abnormalities mediated by clonorchiasis.

  6. Peroxidase activity was markedly reduced by mutation at either of the Leu sites and was essentially abolished by the double mutation, while PLA2 (show YWHAZ Antibodies) activity was unaffected. Decreased peroxidase activity following mutation of the interfacial leucines presumably is mediated via impaired heterodimerization of Prdx6 with piGST that is required for reduction and re-activation of the oxidized enzyme.

  7. PRX6 protein is associated with fetal esophageal development and cancer differentiation.

  8. Mutational analysis of functional sites showed that both peroxidase and PLA2 (show YWHAZ Antibodies) active sites were necessary for mutant Prdx6 function, and that Prdx6 phosphorylation (at T177 residue) was essential for optimum PLA2 (show YWHAZ Antibodies) activity.Mutant Prdx6 at its Sumo1 (show SUMO1 Antibodies) sites escapes and abates this adverse process by maintaining its integrity and gaining function

  9. PRDX6 inhibited the carcinogenesis of hepatocellular carcinoma, and the calcium-independent phospholipase A2 (show PNPLA8 Antibodies) activity of PRDX6 promoted cancer cell death induced by TNF-alpha (show TNF Antibodies).

  10. the data demonstrate that Prdx6 interrupts the formation of TRAF6 (show TRAF6 Antibodies)-ECSIT (show ECSIT Antibodies) complex induced by TLR4 (show TLR4 Antibodies) stimulation, leading to suppression of bactericidal activity because of inhibited mROS production in mitochondria and the inhibition of NF-kappaB (show NFKB1 Antibodies) activation in the cytoplasm.

Mouse (Murine) Peroxiredoxin 6 (PRDX6) interaction partners

  1. Data (including data from studies in transgenic rats and knockout mice) suggest that Nfe2l2 (show NFE2L2 Antibodies) and Prdx6 are involved in biosynthesis of palmitic acid ester of 9-hydroxystearic acid in white adipose tissue (WAT); these proteins appear to be play roles in defense against oxidative stress in WAT. (Nfe2l2 (show NFE2L2 Antibodies) = nuclear factor erythroid 2-like 2 (show NFE2L2 Antibodies) nuclear factor; Prdx6 = peroxiredoxin-6)

  2. Our data indicate that a lack of the antioxidant enzyme PRDX6 protects against the development of acute and chronic experimental colitis and is associated with increased expression and function of other antioxidant enzymes

  3. The constitutive elevations of Prdx6 and NF-kappaB (show NFKB1 Antibodies) during Clonorchis sinensis infection may be associated with more severe persistent hepatobiliary abnormalities mediated by clonorchiasis.

  4. Detailed analysis of the redox-active cysteine in one protein in the nerve of old mice that is key to redox signalling (Peroxiredoxin 6, Cys (show DNAJC5 Antibodies) 47) showed a minor increase in reversible oxidation that would be compatible with a change in its redox signalling function

  5. The results suggest that PRDX1 (show PRDX1 Antibodies) contributes to host defenses against M. tuberculosis PRDX1 (show PRDX1 Antibodies) positively regulates IL-12 (show IL12A Antibodies) production by inducing c-Rel (show NFkBP65 Antibodies) and activating p38 MAPK (show MAPK14 Antibodies), and it positively regulates NO production by suppressing Arg1 (show ARG1 Antibodies) expression in macrophages infected with M. tuberculosis.

  6. This study indicated that Prdx6 decreased LPS (show TLR4 Antibodies)-induced Muc5ac increase and played important roles in mucin (show SLC13A2 Antibodies) hypersecretion after LPS (show TLR4 Antibodies) exposure.

  7. PRDX6 inhibited the carcinogenesis of hepatocellular carcinoma, and the calcium-independent phospholipase A2 (show LYPLA1 Antibodies) activity of PRDX6 promoted cancer cell death induced by TNF-alpha (show TNF Antibodies).

  8. Studies in knockout and knock-in mice showed that the phospholipase A2 (show YWHAZ Antibodies) activity of peroxiredoxin 6 activates NOX2 (show CYBB Antibodies) in cultured pulmonary endothelial cells and alveolar macrophages, clarifying the metabolism of lysophosphatidyl chold to lysophosphatidic acid.

  9. Prdx6 knockout males are more vulnerable to oxidative stress than WT males, resulting in impairment of sperm quality and ability to fertilize the oocyte, compatible with the subfertility phenotype observed in these knockout mice.

  10. Thr (show TRH Antibodies) can substitute for Ser (show SIGLEC1 Antibodies) for the enzymatic activities of Prdx6 but not for its targeting to LB. These results confirm an important role for LB Prdx6 in the degradation and remodeling of lung surfactant phosphatidylcholine (show SGMS2 Antibodies).

Cow (Bovine) Peroxiredoxin 6 (PRDX6) interaction partners

  1. study demonstrated involvement of cytosolic and calcium-independent phospholipase A (show HRASLS Antibodies)(2) and the contribution of cyclooxygenase-2 (show PTGS2 Antibodies) products in E. coli invasion of brain microvascular endothelial cells

  2. dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB (show CREB1 Antibodies) phosphorylation mediated by iPLA2 (show PLA2G6 Antibodies).

  3. PRDX6 upregulation in cumulus-oocyte complexes during in vitro maturation is mutually regulated by both cell types.

Xenopus laevis Peroxiredoxin 6 (PRDX6) interaction partners

  1. Gene expressionof Prx6 increased during development, especially at stages 33-43 during formation of the lungs.

Pig (Porcine) Peroxiredoxin 6 (PRDX6) interaction partners

  1. The expression of porcine Prdx6 gene is up-regulated by C/EBPbeta (show CEBPB Antibodies) and CREB (show CREB1 Antibodies).

  2. The SNP of PRDX6 gene was significantly associated with the intramuscular fat and water moisture.

Peroxiredoxin 6 (PRDX6) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell\; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Gene names and symbols associated with anti-Peroxiredoxin 6 (PRDX6) Antibodies

  • peroxiredoxin 6 (PRDX6) antibody
  • peroxiredoxin 6 (Prdx6) antibody
  • peroxiredoxin 6 (prdx6) antibody
  • peroxiredoxin 6 S homeolog (prdx6.S) antibody
  • peroxiredoxin 6 L homeolog (prdx6.L) antibody
  • 1-Cys antibody
  • 1-cysPrx antibody
  • 9430088D19Rik antibody
  • AA690119 antibody
  • aiPLA2 antibody
  • aop2 antibody
  • Aop2-rs3 antibody
  • Brp-12 antibody
  • CC26 antibody
  • CP-3 antibody
  • GPx antibody
  • Ltw-4 antibody
  • Ltw4 antibody
  • Lvtw-4 antibody
  • mKIAA0106 antibody
  • NSGP antibody
  • NSGPx antibody
  • ORF06 antibody
  • p29 antibody
  • PHGPX antibody
  • Prdx5 antibody
  • prdx6 antibody
  • Prdx6-rs3 antibody
  • PRX antibody
  • prx-6 antibody
  • prx6 antibody
  • zgc:73360 antibody

Protein level used designations for anti-Peroxiredoxin 6 (PRDX6) Antibodies

1-Cys PRX , 1-Cys peroxiredoxin , 24 kDa protein , acidic calcium-independent phospholipase A2 , antioxidant protein 2 , liver 2D page spot 40 , non-selenium glutathione peroxidase , peroxiredoxin-6 , red blood cells page spot 12 , 1-Cys Prx , anti-oxidant protein 2, related sequence 3 , peroxiredoxin 5, related sequence 3 , peroxiredoxin 6, related sequence 3 , NSGPx , aiPLA2 , thiol-specific antioxidant protein , PHGPx , anti-oxidant protein 2 (non-selenium glutathione peroxidase, acidic calcium-independent phospholipase A2) , calcium-independent phospholipase A2 , ciliary body glutathione peroxidase , peroxiredoxin 6 , non-selenium glutathione phospholipid hydroperoxide peroxidase

GENE ID SPECIES
9588 Homo sapiens
11758 Mus musculus
94167 Rattus norvegicus
282438 Bos taurus
393778 Danio rerio
394706 Xenopus (Silurana) tropicalis
398641 Xenopus laevis
399434 Xenopus laevis
429062 Gallus gallus
496787 Xenopus (Silurana) tropicalis
100304983 Ictalurus punctatus
399538 Sus scrofa
100173342 Pongo abelii
101842872 Mesocricetus auratus
100731397 Cavia porcellus
480069 Canis lupus familiaris
101112748 Ovis aries
101691344 Mustela putorius furo
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