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PEX19 is necessary for early peroxisomal biogenesis. Additionally we are shipping PEX19 Antibodies (116) and and many more products for this protein.
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that newly synthesized UBXD8 (show FAF2 Proteins) is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3 (show PEX3 Proteins), proteins hitherto exclusively implicated in peroxisome biogenesis
Thus within the cell, PEX3 (show PEX3 Proteins) is stabilized by PEX19 preventing PEX3 (show PEX3 Proteins) aggregation.
PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 (show PEX26 Proteins) in the cytosol and translocated it directly to peroxisomes by a TRC40 (show ASNA1 Proteins)-independent class I pathway.
PEX3 (show PEX3 Proteins)-PEX19 interaction is crucial for de novo formation of peroxisomes in peroxisome-deficient cells.
The crystal structure of the cytosolic domain of PEX3 (show PEX3 Proteins) in complex with a PEX19-derived peptide. PEX3 (show PEX3 Proteins) adopts a novel fold that is best described as a large helical bundle.
a considerable functional diversity of the proteins encoded by two PEX19 splice variants and thereby provide first experimental evidence for specific biological functions of the different predicted domains of the PEX19 protein.
PEX19 binds and stabilizes newly synthesized PMPs in the cytosol, binds to multiple PMP targeting signals (mPTSs), interacts with the hydrophobic domains of PMP targeting signals, and is essential for PMP targeting and import.
Interaction of PEX3 (show PEX3 Proteins) and PEX19 visualized by fluorescence resonance energy transfer (FRET).
Pex19p has a role in assembly of PTS (show PTS Proteins)-receptor docking complexes
Results suggest that PEX3 (show PEX3 Proteins) plays a selective, essential, and direct role in class I peroxisomal membrane protein import as a docking factor for PEX19.
This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants.
, peroxin 19
, peroxisomal farnesylated protein
, Peroxisomal farnesylated protein
, 33 kDa housekeeping protein
, housekeeping gene, 33kD
, peroxisome biogenesis factor 19