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The product of PEX3 is involved in peroxisome biosynthesis and integrity. Additionally we are shipping PEX3 Antibodies (30) and and many more products for this protein.
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that newly synthesized UBXD8 (show FAF2 Proteins) is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 (show PEX19 Proteins) and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis
This insertion of PEX3 into the ER is physiologically relevant.
PEX16 (show PEX16 Proteins) mediates the peroxisomal trafficking of two distinct peroxisomal membrane proteins, PEX3 and PMP34 (show SLC25A17 Proteins), via the endoplasmic reticulum
Thus within the cell, PEX3 is stabilized by PEX19 (show PEX19 Proteins) preventing PEX3 aggregation.
Mutations in the PEX19 (show PEX19 Proteins)-binding domain of PEX3 reduce the affinity for PEX19 (show PEX19 Proteins) and destabilize PEX3.
The crystal structure of the cytosolic domain of PEX3 in complex with a PEX19 (show PEX19 Proteins)-derived peptide. PEX3 adopts a novel fold that is best described as a large helical bundle.
Interaction of PEX3 and PEX19 (show PEX19 Proteins) visualized by fluorescence resonance energy transfer (FRET).
Results suggest that PEX3 plays a selective, essential, and direct role in class I peroxisomal membrane protein import as a docking factor for PEX19 (show PEX19 Proteins).
either one or two tryptophan residues of Pex3p (Trp (show TBPL1 Proteins)-104 and Trp (show TBPL1 Proteins)-224) are directly involved in binding to Pex19p.
The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids.
The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS).
peroxisomal biogenesis factor 3
, transmembrane protein
, peroxisomal assembly protein PEX3
, transformation-related protein 18
, Peroxisomal assembly protein PEX3
, peroxisomal assembly protein 3
, Peroxisomal biogenesis factor 3