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The protein encoded by PPAN is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan).
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a novel nucleolar stress-response pathway involving PPAN, NPM (show NPM1 Proteins), and BAX (show BAX Proteins) to guarantee cell survival in a p53 (show TP53 Proteins)-independent manner.
The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation.
suppressor of SWI4 1 homolog
, brix domain-containing protein 3
, homolog of S. cerevisiae SSF1
, second-step splicing factor 1
, suppressor of sterile four 1