Phenylalanine-tRNA Synthetase 2 (Mitochondrial) Proteins (FARS2)

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Additionally we are shipping Phenylalanine-tRNA Synthetase 2 (Mitochondrial) Antibodies (32) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FARS2 69955 Q99M01
FARS2 10667 O95363
FARS2 306879 Q6AYQ3
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Top Phenylalanine-tRNA Synthetase 2 (Mitochondrial) Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Mouse T7 tag,His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Rat T7 tag,His tag 100 μg Log in to see 15 to 18 Days

FARS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, , ,
Rat (Rattus)

More Proteins for Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) Interaction Partners

Human Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) interaction partners

  1. Based on the phenotypic data of previously reported subjects and the two subjects reported here, we conclude that FARS2 deficiency can be associated with two phenotypes: (i) an epileptic phenotype, and (ii) a spastic paraplegia phenotype.

  2. in patients with drug-resistant infantile spasm syndrome, associated with focal seizures, mild metabolic changes, and cerebral atrophy with volume loss of white matter on MRI, mutations in FARS2 should be considered.

  3. Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2 have been described.

  4. A newly identified missense mutation in FARS2 causes autosomal-recessive spastic paraplegia.

  5. this study expands the phenotypic spectrum of FARS2 related disease and emphasizes intragenic deletion in the list of causative mutations.

  6. the three FARS2 mutations directly impair aminoacylation function and stability of mtPheRS, leading to a decrease in overall tRNA charging capacity.

  7. Two phenylalanyl-tRNA synthetase variants Ser57Cys and Asp280Ser both display wild-type aminoacylation activity and stability with respect to their free energies of unfolding, but are less stable at low hydrogen-ion concentration (pH).

  8. The recombinant human enzyme has been purified to homogeneity and crystallized in complex with phenylalanine and ATP.

  9. Formation of the PheRS-tRNAPhe complex in human mitochondria must be accompanied by considerable rearrangement of the anticodon binding domain upon tRNA binding.

  10. Mitochondrial and cytoplasmic phenylalanyl-tRNA synthetases (HsmtPheRS and HsctPheRS, respectively) catalyze direct attachment of m-Tyr to tRNA(Phe).

  11. these results indicate that conformational flexibility of the two functional modules in mtPheRS is essential for its phenylalanylation activity.

Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) Protein Profile

Protein Summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.

Gene names and symbols associated with FARS2

  • phenylalanine-tRNA synthetase 2 (mitochondrial) (Fars2)
  • phenylalanyl-tRNA synthetase 2, mitochondrial (FARS2)
  • phenylalanyl-tRNA synthetase 2, mitochondrial (Fars2)
  • 2810431B21Rik protein
  • 6720478K01Rik protein
  • COXPD14 protein
  • dJ520B18.2 protein
  • FARS1 protein
  • HSPC320 protein
  • PheRS protein

Protein level used designations for FARS2

pheRS , phenylalanine--tRNA ligase, mitochondrial , phenylalanine-tRNA synthetase 1 (mitochondrial) , phenylalanyl-tRNA synthetase, mitochondrial , dJ236A3.1 (phenylalanine-tRNA synthetase) , dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase)) , phenylalanine tRNA ligase 2, mitochondrial , phenylalanine translase , phenylalanine-tRNA synthetase 2 (mitochondrial)

69955 Mus musculus
10667 Homo sapiens
488204 Canis lupus familiaris
505390 Bos taurus
306879 Rattus norvegicus
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