Phosphate Regulating Endopeptidase Homolog, X-Linked Proteins (PHEX)

The protein encoded by PHEX is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. Additionally we are shipping PHEX Antibodies (44) and PHEX Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PHEX 5251 P78562
Rat PHEX PHEX 25512  
PHEX 18675 P70669
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Top PHEX Proteins at

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 2 to 3 Days

PHEX Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) Interaction Partners

Human Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) interaction partners

  1. Nonsense mutation (p.E145*) in PHEX is involved in X-linked dominant hypophosphatemic rickets.

  2. Two novel variants of the PHEX gene were identified in two unrelated families with Xlinked dominant hypophosphatemic rickets by directly sequencing all 22 exon regions and intron/exon boundaries of the PHEX gene.

  3. genetic characteristics of 15 families with hereditary hypophosphatemia: Novel Mutations in PHEX and SLC34A3 (show SLC34A3 Proteins)

  4. PHEX mutations are still the most common genetic defects in the Turkish population and were found in 12 of 14 patients with hypophosphataemic rickets

  5. dentification of the PHEX mutation by whole exome sequencing has facilitated genetic counseling and prenatal diagnosis for the family affected with hypophosphatemic rickets

  6. Expression and inactivation of osteopontin (show SPP1 Proteins)-degrading PHEX enzyme in squamous cell carcinoma

  7. The novel splicing mutation IVS21+2T>G of the PHEX geneis associated with X-linked hypophosphatemia.

  8. c.931dupC and IVS14+1G>A are two novel mutations of the PHEX gene and might be the new pathogenic mutations of X-linked hypophosphatemic rickets

  9. Herpes simplex virus 1 blocks MAVS (show MAVS Proteins)-Pex mediated early interferon (show IFNA Proteins)-stimulated gene activation through VP16 to dampen the immediate early (show JUN Proteins) antiviral innate immunity signaling from peroxisomes.

  10. Mutation in the PHEX gene is associated with type 1 diabetes.

Mouse (Murine) Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) interaction partners

  1. the phex mutation may create the lower set point for extracellular phosphate concentrations in a murine model of X-linked hypophosphatemia

  2. Hyp/Lrp6 (show LRP6 Proteins) double mutants developed the same reduced bone mineralization,hypophosphatemia & high FGF23 (show FGF23 Proteins) levels as Hyp(-) mice, showing that WNT (show WNT2 Proteins) signaling does not affect the FGF23 (show FGF23 Proteins)-induced phosphate wasting.

  3. demonstrates a previously unknown impact of retinol on the cell-autonomous mineralization defect of Phex-deficient osteoblasts

  4. results identify full-length OPN (show SPP1 Proteins) as novel, physiologically relevant substrates for PHEX, suggesting accumulation of mineralization-inhibiting OPN (show SPP1 Proteins) fragments may contribute to the mineralization defect seen in the osteomalacic bone characteristic of XLH/HYP

  5. Mutation in Phex gene predisposes BALB/c-Phex(Hyp-Duk)/Y mice to otitis media.

  6. These data suggest that Phex mutations alter the responsiveness of bone cells to extracellular phosphate concentrations and may create a lower set point for "normal" phosphate levels.

  7. PHEX and DMP1 (show DMP1 Proteins) control a common pathway regulating bone mineralization and FGF23 (show FGF23 Proteins) production, the latter involving activation of the FGFR (show FGFR2 Proteins) signaling in osteocytes.

  8. ASARM peptides likely play a bone PHEX-dependent role in renal phosphate regulation and FGF23 (show FGF23 Proteins) expression.

  9. Cooperative role of NF-{kappa}B (show NFKB1 Proteins) and poly(ADP-ribose) polymerase 1 (PARP-1 (show PARP1 Proteins)) in the TNF (show TNF Proteins)-induced inhibition of PHEX expression in osteoblasts.

  10. OPN (show SPP1 Proteins) ASARM inhibits mineralization by binding to hydroxyapatite in a phosphorylation-dependent manner and can be cleaved by PHEX.

PHEX Protein Profile

Protein Summary

The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets.

Gene names and symbols associated with PHEX

  • phosphate regulating endopeptidase homolog X-linked (PHEX)
  • phosphate regulating endopeptidase homolog, X-linked (Phex)
  • Gy protein
  • HPDR protein
  • HPDR1 protein
  • Hyp protein
  • HYP1 protein
  • LXHR protein
  • PEX protein
  • XLH protein

Protein level used designations for PHEX

X-linked hypophosphatemia protein , metalloendopeptidase homolog PEX , phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) , phosphate-regulating neutral endopeptidase , vitamin D-resistant hypophosphatemic rickets protein , phosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, vitamin D resistant rickets) , Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH) , Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein) , X-linked phosphate regulating endopeptidase , phosphate regulating neutral endopeptidase

5251 Homo sapiens
480862 Canis lupus familiaris
100154258 Sus scrofa
536029 Bos taurus
25512 Rattus norvegicus
18675 Mus musculus
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