Phosphate Regulating Endopeptidase Homolog, X-Linked Proteins (PHEX)

The protein encoded by PHEX is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. Additionally we are shipping PHEX Antibodies (42) and PHEX Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PHEX 5251 P78562
Rat PHEX PHEX 25512  
PHEX 18675 P70669
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days

PHEX Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

More Proteins for Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) Interaction Partners

Human Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) interaction partners

  1. Hypophosphatemia alone does not fully explain the pathologic phenotype observed in XLH. Loss of PHEX independently and locally affects ECM mineral formation and quality, likely through the accumulation and impaired degradation of OPN and possibly through changes in DMP1 and MEPE cleavage.

  2. PARP1 enzymatic activity did not significantly reverse the effect of TNF on the human PHEX gene expression.

  3. PHEX gene mutations are associated with hypophosphatemic rickets in the Chinese family.

  4. Nonsense mutation (p.E145*) in PHEX is involved in X-linked dominant hypophosphatemic rickets.

  5. Two novel variants of the PHEX gene were identified in two unrelated families with Xlinked dominant hypophosphatemic rickets by directly sequencing all 22 exon regions and intron/exon boundaries of the PHEX gene.

  6. genetic characteristics of 15 families with hereditary hypophosphatemia: Novel Mutations in PHEX and SLC34A3

  7. PHEX mutations are still the most common genetic defects in the Turkish population and were found in 12 of 14 patients with hypophosphataemic rickets

  8. dentification of the PHEX mutation by whole exome sequencing has facilitated genetic counseling and prenatal diagnosis for the family affected with hypophosphatemic rickets

  9. Expression and inactivation of osteopontin-degrading PHEX enzyme in squamous cell carcinoma

  10. The novel splicing mutation IVS21+2T>G of the PHEX geneis associated with X-linked hypophosphatemia.

  11. c.931dupC and IVS14+1G>A are two novel mutations of the PHEX gene and might be the new pathogenic mutations of X-linked hypophosphatemic rickets

  12. Herpes simplex virus 1 blocks MAVS-Pex mediated early interferon-stimulated gene activation through VP16 to dampen the immediate early antiviral innate immunity signaling from peroxisomes.

  13. Mutation in the PHEX gene is associated with type 1 diabetes.

  14. the findings of this study provide new insight into the spectrum of PHEX mutations and provide potential evidence of a critical domain in PHEX protein.

  15. This report that mutations in PHEX are the most frequent cause of hypophosphatemic rickets

  16. Downregulation of PHEX may constitute an important early component of bone loss and joint damage in leprosy

  17. A new splice acceptor mutation was seen in intron 9 (c.1080-3C>A) in a family with hypophosphatemic rickets. This transcript skipped exons 10-14. A sporadic case had a new exon 11 mutation (c.1211_1215delACAAAinsTTTACAT, p.Asp404Valfs*5, de novo).

  18. Two novel mutations were detected unrelated families with hypophosphatemic rickets.

  19. PHEX c.*231A > G can masquerade as sporadic or X-linked recessive HR.

  20. A novel de novo nonsense mutation of the PHEX gene has been identified in Chinese family expanding the mutation spectrum of PHEX leading to X-linked hypophosphatemic rickets.

Mouse (Murine) Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) interaction partners

  1. the phex mutation may create the lower set point for extracellular phosphate concentrations in a murine model of X-linked hypophosphatemia

  2. Hyp/Lrp6 double mutants developed the same reduced bone mineralization,hypophosphatemia & high FGF23 levels as Hyp(-) mice, showing that WNT signaling does not affect the FGF23-induced phosphate wasting.

  3. demonstrates a previously unknown impact of retinol on the cell-autonomous mineralization defect of Phex-deficient osteoblasts

  4. results identify full-length OPN as novel, physiologically relevant substrates for PHEX, suggesting accumulation of mineralization-inhibiting OPN fragments may contribute to the mineralization defect seen in the osteomalacic bone characteristic of XLH/HYP

  5. Mutation in Phex gene predisposes BALB/c-Phex(Hyp-Duk)/Y mice to otitis media.

  6. These data suggest that Phex mutations alter the responsiveness of bone cells to extracellular phosphate concentrations and may create a lower set point for "normal" phosphate levels.

  7. PHEX and DMP1 control a common pathway regulating bone mineralization and FGF23 production, the latter involving activation of the FGFR signaling in osteocytes.

  8. ASARM peptides likely play a bone PHEX-dependent role in renal phosphate regulation and FGF23 expression.

  9. Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts.

  10. OPN ASARM inhibits mineralization by binding to hydroxyapatite in a phosphorylation-dependent manner and can be cleaved by PHEX.

  11. Preproenkephalin deletion in Hyp mice (Phex-deficient) partially rescues their bone mineralization defect.

  12. Phex protein is expressed in osteoblasts and osteocytes during the embryonic and postnatal periods

  13. Glucocorticoid regulation of the murine PHEX gene.

  14. MEPE may be involved in the pathogenesis defective mineralization due to Phex deficiency in X-linked hypophosphatemia (XLH) and the Hyp-mouse.

  15. mutagen-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets

  16. findings suggest that hypophosphatemia bone and teeth abnormalities partially correct after phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) gene transfer but additional factors of PHEX expression are likely critical

  17. rickets and osteomalacia are not the only causes of decreased vertebral growth in Hyp mice and Phex protein may influence bone growth and mineralization by distinct pathways

  18. Phex may control mineralization and removal of hypertrophic chondrocytes and cartilage matrix in growth plate by regulating the synthesis and deposition of certain bone matrix proteins and proteases such as matrix metalloproteinase 9

  19. downregulation of Phex expression by PTH in vitro is associated with inhibition of matrix mineralization, consistent with a role for Phex in bone mineralization

  20. TNF-alpha-mediated reduction in Phex protein is at least in part responsible for inhibition of osteoblast mineralization, and the described mechanism may contribute to the abnormal bone metabolism associated with IBD.

PHEX Protein Profile

Protein Summary

The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets.

Gene names and symbols associated with PHEX

  • phosphate regulating endopeptidase homolog X-linked (PHEX)
  • phosphate regulating endopeptidase homolog, X-linked (Phex)
  • Gy protein
  • HPDR protein
  • HPDR1 protein
  • Hyp protein
  • HYP1 protein
  • LXHR protein
  • PEX protein
  • XLH protein

Protein level used designations for PHEX

X-linked hypophosphatemia protein , metalloendopeptidase homolog PEX , phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) , phosphate-regulating neutral endopeptidase , vitamin D-resistant hypophosphatemic rickets protein , phosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, vitamin D resistant rickets) , Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH) , Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein) , X-linked phosphate regulating endopeptidase , phosphate regulating neutral endopeptidase

5251 Homo sapiens
480862 Canis lupus familiaris
100154258 Sus scrofa
536029 Bos taurus
25512 Rattus norvegicus
18675 Mus musculus
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