Phosphatidylethanolamine-Binding Protein 4 Proteins (PEBP4)

Mouse (Murine) Phosphatidylethanolamine-Binding Protein 4 (PEBP4) interaction partners

1. PEBP4 is a secreted protein and has multiple functions, including a role in Akt phosphorylation.

2. We describe the cloning and functional characterization of the mouse homolog of hPEBP4 (mPEBP4). We demonstrate that mPEBP4 promotes cellular migration and invasion by inhibiting ERK1/2 and JNK activation and up-regulating the expression of COX-2.

Human Phosphatidylethanolamine-Binding Protein 4 (PEBP4) interaction partners

1. PEBP4 was associated with the development and invasion of gastric cancer cells through activation of the PI3K/Akt signaling pathway

2. knockdown of PEBP4 inhibited hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells.

3. this study suggested that PEBP4 might promote the progression of pancreatic ductal adenocarcinoma

4. Increased expression of phosphatidylethanolamine-binding protein 4 strongly associates with gliomas grade.

5. PEBP4 is a secreted protein and has multiple functions, including a role in Akt phosphorylation.

6. Increased miR-15b expression in lung adenocarcinoma patients treated with cisplatin-based chemotherapy was correlated with low expression of PEBP4, decreased sensitivity to cisplatin and poor prognosis.

7. overexpression of PEBP4, which we show to be a target of miR-34a, reduces the sensitivity of lung cancer cells to cisplatin

8. in human breast cancer hPEBP4 is a novel and clinically relevant metastasis accelerator gene

9. Human PEBP4 expression correlates negatively with estrogen and progesterone receptors in endometrial carcinoma.

10. hPEBP4 knockdown potentiated the chemosensitization of the rituximab in B-cell lymphoma cells by regulating the expression of Bcl-xl, Cycline E, p21(waf/cip1) and p53 and the activation of caspase-3 and caspase-9.

11. the independent predictive values of hPEBP4 in response of rectal cancer to preoperative radiotherapy, are reported.

12. PEBP4 enhanced cell proliferation and invasion ability and inhibited apoptosis. Decreased PEBP4 expression may play a role in the reduced invasion ability and increased apoptosis of the human non-small cell lung cancer cell line HCC827.

13. PEBP4 over-expression may promote the invasion and metastasis of non-small cell lung cancer.

14. The over-expression of PEBP4 protein may be related to the tumorigenesis, development, metastasis, and invasion of colorectal cancer.

15. Data show that PEBP4 protein overexpression was associated with the occurrence, invasion, and metastasis of lung squamous cell carcinoma.

16. hPEBP4 inhibits proteasome-dependent ERalpha degradation through the Src pathway.

17. hPEBP4 promotes cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK, and PE externalization.

18. Silencing of hPEBP4, an important potential target, may be a promising approach for the treatment of ovarian cancer.

19. Data show that PEBP4 participates in the control of muscle cell differentiation by modulating the activity of MEK and ERK.