Phosphoglycerate Mutase Family Member 5 Proteins (PGAM5)

Fruit Fly (Drosophila melanogaster) Phosphoglycerate Mutase Family Member 5 (PGAM5) interaction partners

1. the mushroom body may possess an apoptosis-dependent toxic function, the suppression of which by dPGAM5 appears to be crucial for heat shock resistance.

2. PGAM5 negatively regulates the PINK1 (show PINK1 Proteins) pathway related to maintenance of the mitochondria.

Human Phosphoglycerate Mutase Family Member 5 (PGAM5) interaction partners

1. PGAM5 regulates histidine phosphorylation to control TCR activation of CD4 (show CD4 Proteins)-positive T cells.

2. Results indicate that a multiprotein complex including PGAM5, Bax and Drp1 proteins specifically formed during intrinsic apoptosis induction.

3. Results identify a crucial role for RIPK3 (show RIPK3 Proteins)-PGAM5-Drp1 (show CRMP1 Proteins)/NFAT (show NFATC1 Proteins) signalling in NKT (show SLC22A6 Proteins) cell activation, and further suggest that RIPK3 (show RIPK3 Proteins)-PGAM5 signalling may mediate crosstalk between mitochondrial function and immune signalling.

4. The BCL2L1 (show BCL2L1 Proteins)-PGAM5-FUNDC1 (show FUNDC1 Proteins) axis is critical for receptor-mediated mitophagy.

5. Dephosphorylation of FUNDC1 (show FUNDC1 Proteins) by PGAM5 induces mitophagy.

6. PGAM5 is proteolytically processed, accumulates in the cytosol during apoptosis, and sensitizes cells to death.

7. Rhomboid protease PARL (show PARL Proteins) mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.

8. Experimental data indicate that the two splice variants of the mitochondrial protein (show COX6B2 Proteins) phosphatase PGAM5 are at the convergent point of multiple necrosis pathways.

9. The N terminus of the PGAM5 protein contains a conserved NXESGE motif that binds to the substrate binding pocket in the Kelch domain of Keap1 (show KEAP1 Proteins).

10. Results suggest that this member of the PGAM family has crossed over from small molecules to protein substrates and been adapted to serve as a specialized activator of ASK1 (show MAP3K5 Proteins).

Mouse (Murine) Phosphoglycerate Mutase Family Member 5 (PGAM5) interaction partners

1. findings suggest that HO-1 (show HMOX1 Proteins) protects against I/R-induced hepatic injury via regulation of mitochondrial QC by PGAM5 signaling.

2. Taken together, our findings provide evidence that NBP can attenuate the progression of EAE by suppressing PGAM5-induced necroptosis and inflammation in microglia and represents a new therapeutic strategy for treating autoimmune diseases.

3. PGAM5 regulates histidine phosphorylation to control TCR activation of CD4 (show CD4 Proteins)-positive T cells.

4. Results revealed that RIPK1 (show RIPK1 Proteins) and PGAM5 function independently to exert optimal control of Leishmania replication in the host.

5. Our data demonstrate for the first time that PGAM5 plays an indispensable role in the pathogenesis of ConA-induced liver injury.

6. we also found that Pgam5-deficient mice are resistant to high-fat-diet-induced obesity. Our study uncovered that PGAM5 is involved in the whole-body metabolism in response to stresses that impose metabolic challenges on mitochondria.

7. Our results revise the former proposal that PGAM5 acts downstream of RIP1 (show RALBP1 Proteins)/RIP3 to mediate necroptosis. Instead, PGAM5 protects cells from necroptosis by independently promoting mitophagy.

8. PGAM5 is a novel regulator of inflammasome and caspase 1 (show CASP1 Proteins) activity that functions independently of RIPK3 (show RIPK3 Proteins).

9. Results identify a crucial role for RIPK3 (show RIPK3 Proteins)-PGAM5-Drp1 (show CRMP1 Proteins)/NFAT (show NFATC1 Proteins) signalling in NKT (show CTSL1 Proteins) cell activation, and further suggest that RIPK3 (show RIPK3 Proteins)-PGAM5 signalling may mediate crosstalk between mitochondrial function and immune signalling.

10. Loss of PGAM5 disables PINK1 (show PINK1 Proteins)-mediated mitophagy in vitro and leads to dopaminergic neurodegeneration and mild dopamine loss in vivo causing a Parkinson's-like movement disorder.

Xenopus laevis Phosphoglycerate Mutase Family Member 5 (PGAM5) interaction partners

1. Pgam5 is essential for head formation, and for establishing and maintaining the Wnt (show WNT2 Proteins)/beta-Catenin (show CTNNB1 Proteins) signaling gradient that patterns the anterior-posterior body axis. We show that Pgam5 interacts with Dishevelled2 and that Dishevelled2 is a substrate of Pgam5.