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may play a role in phospholipase activation, production of prostaglandins, and regulation of inflammatory response [RGD, Feb 2006].. Additionally we are shipping PLAA Antibodies (87) and PLAA Proteins (14) and many more products for this protein.
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In both human and mouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysfunction syndrome with seizures.
Upon damage, p97 translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1, PLAA, and the deubiquitinating enzyme YOD1, which we term ELDR components for Endo-Lysosomal Damage Response.
This study presented that Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy.
This review provides evidence that 1,25-dihydroxy vitamin D3 stimulates PLA2 (show YWHAZ ELISA Kits) via PLAA and CaMKII (show CAMK2G ELISA Kits), a process initiated by Pdia3 (show PDIA3 ELISA Kits)/PLAA interaction, which further triggers CaMKII (show CAMK2G ELISA Kits)-dependent PLA2 (show YWHAZ ELISA Kits) activation. [review]
PLAP (show ALP ELISA Kits) inhibits sPLA2 (show PLA2G2A ELISA Kits)-triggered release of fatty acids from erythrocyte membranes
identified one stimulatory element, with Sp1 (show PSG1 ELISA Kits) binding sites, and one inhibitory element, in exon 1 of the plaa gene
Structural basis for ubiquitin recognition by a novel domain from the human phospholipase A2-activating protein
We demonstrate that PLAA is essential for neural function, through dual roles of (1) regulating post-endocytic trafficking of signaling receptors necessary for neural development and (2) directing sorting of synaptic vesicle (SV) components during recycling, essential for synaptic function.
miR (show MLXIP ELISA Kits)-203 may regulate expression of the novel nociceptive mediator PLAA after incision.
Phospholipase A2 activating protein is required for 1alpha,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C (show PKC ELISA Kits) via Pdia3 (show PDIA3 ELISA Kits)
may play a role in phospholipase activation, production of prostaglandins, and regulation of inflammatory response
phospholipase A-2-activating protein
, phospholipase A2-activating protein
, phospholipase A-2-activating protein-like
, DOA1 homolog
, phospholipase A2 activating protein