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The protein encoded by PLCz1 is a member of the phosphoinositide-specific phospholipase C family.
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Results suggest a mechanism by which phospholipase C zeta originates from an oocyte-penetrating assembly--the sperm perinuclear matrix--to induce mammalian oocyte activation at fertilization.
Human PLCzeta exhibits superior fertilization potency over mouse PLCzeta in triggering the Ca(2 (show CA2 ELISA Kits)+) oscillations required for mammalian oocyte activation.
these results suggest that both PLCzeta- and sperm-mediated Ca2 (show CA2 ELISA Kits)+ release preferentially use an intracellular membranous source of PI(4,5)P2, in contrast to PLCdelta1, which targets PI(4,5)P2 in the plasma membrane.
Data suggest that positively charged residues within the XY linker play an important role in the PLCzeta interaction with PtdIns(4,5)P(2), a crucial step in generating the Ca(2 (show CA2 ELISA Kits)+) activation signal that is essential for fertilization in mammals.
Murine PLCZ1 and bovine PLCZ1 possess species-specific differences in activity and suggest potential differences in the mode of action of the protein between the two species.
purified PLCzeta protein induces Ca(2 (show CA2 ELISA Kits)+) oscillations, indicating that PLCzeta is a proper candidate of the mammalian egg-activating sperm factor
Cell cycle-dependent Ca2 (show CA2 ELISA Kits)+ oscillations are regulated by nuclear targeting of PlCzeta.
PLCzeta is the physiological trigger of Ca(2 (show CA2 ELISA Kits)+) oscillations required for activation of development
interaction of PI(3 (show PI3 ELISA Kits))P and PI(5)P could play a role for negative regulation of PLCzeta
PLCzeta exhibited alternative cytoplasm/nucleus localization during development
we evaluate sperm motility and the proportion of sperm expressing PLC (show HSPG2 ELISA Kits) zeta in 71 males (22-54 years; 44 fertile controls and 27 infertile patients), along with total levels and localisation patterns of PLC (show HSPG2 ELISA Kits) zeta within the sperm head.
findings suggest that human PLCZ1 RNA is a better therapeutic agent to rescue human oocytes from failed activation, leading to normal and efficient development.
The value of PAWP (show WBP2NL ELISA Kits) and PLCzeta as indicators of sperm quality was studied.
The role of the PLCZ1 protein in male infertility, and its expression regulation and therapeutic potential have been discussed. (Review)
latest developments that have begun to unravel the vital role of PLCzeta at mammalian fertilisation and decipher its unique mechanism of action within the fertilising egg.
The findings highlight the importance of PLCzeta at fertilization and the vital role of the C2 domain in PLCzeta function, possibly due to its novel binding characteristics.
The findings of the present study illustrate that one of the etiologies of reduced fertility associated with varicocele is the low expression of PLCzeta
In male infertility, the absence of PLCZ1 alone is sufficient to prevent oocyte activation irrespective of the presence of PAWP (show WBP2NL ELISA Kits).
Human PLCzeta elicited the characteristic Ca(2 (show CA2 ELISA Kits)+) oscillations present at mammalian fertilization, which produced oocyte activation and embryo development.
Study further supports the fundamental role of PLCzeta in the oocyte activation process.
Data show that the level of actin/PLC (show PLC ELISA Kits)-zeta interaction was twice as high in G-actin (show ACTB ELISA Kits) that reflected an increase in affinity.
A novel splice variant of Phospholipase C zeta 1 in the testis tissues of adult and fetal Chinese Holstein bulls was characterized.
Murine PLCZ1 and bovine PLCZ1 possess species-specific differences in activity and suggest potential differences in the mode of action of the protein between the two species
The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
, Phospholipase C-zeta-1
, phosphoinositide phospholipase C-zeta-1
, phospholipase C zeta
, phospholipase C-zeta-1
, PI-phospholipase C zeta 1
, testis-development related NYD-SP27