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Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Additionally we are shipping LHPP Antibodies (35) and LHPP Kits (8) and many more products for this protein.
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LHPP suppresses cell proliferation and metastasis in cervical cancer, and promotes apoptosis by suppressing AKT activation.
in patients with hepatocellular carcinoma, low expression of LHPP correlated with increased tumour severity and reduced overall survival; thus LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic
LHPP is associated with the interplay of risky sexual behaviors and alcohol dependence.
Patients with major depressive disorder with LHPP rs35936514 CT/TT genotype have increased activity in certain brain regions.
LHPP gene variation is associated with oral cavity and pharyngeal cancer.
Lhpp or a product of a collinear brain-specific transcript, therefore, may interact with Htr1a in the pathogenesis of major depression
Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).
phospholysine phosphohistidine inorganic pyrophosphate phosphatase