Pirin Proteins (PIR)

PIR encodes a member of the cupin superfamily. Additionally we are shipping Pirin Antibodies (50) and Pirin Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIR 8544 O00625
PIR 69656 Q9D711
PIR 363465 Q5M827
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Top Pirin Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 60 to 71 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days

PIR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Pirin (PIR) Interaction Partners

Human Pirin (PIR) interaction partners

  1. Data suggest that only the Fe(III) form of pirin [not the Fe(II) form] enhances affinity of binding between p65 (show GORASP1 Proteins) and DNA in the pirin-p65 (show GORASP1 Proteins)-DNA supramolecular complex. (pirin = quercetin 2,3-dioxygenase; p65 (show GORASP1 Proteins) = RELA (show NFkBP65 Proteins) proto-oncogene (show RAB1A Proteins) NF-kappaB (show NFKB1 Proteins) subunit)

  2. Pirin regulates E-cadherin independently of Bcl3-Slug signaling.

  3. The NRF2 transcription factor binds to this element in vivo and drives the basal PIR expression.

  4. Pirin is a newly identified binding partner of EAF2/U19 (show EAF2 Proteins) capable of down-regulating EAF2/U19 (show EAF2 Proteins) protein and alleviating its inhibition of prostate cancer cell survival/proliferation.

  5. Data indicate that the R-shaped area composes the interface for pirin-NF-kappaB (show NFKB1 Proteins) binding that is responsible for modulation of NF-kappaB's DNA-binding properties.

  6. pirin may have a relevant role in melanoma progression.

  7. knockdown of pirin or treatment with the small molecule inhibited melanoma cell migration

  8. This study aimed to examine genetic variations in the PIR gene by a comprehensive tagging method and its sex-specific effects on bone mineral density and osteoporotic risk.

  9. An abnormal pattern of PIR sub-cellular localization is a characteristic feature of a subset of melanomas, and suggest it may represent a marker associated with disease progression.

  10. Pirin downregulation is a feature of acute myeloid leukemia (show BCL11A Proteins) and leads to impairment of terminal myeloid differentiation.

Arabidopsis thaliana Pirin (PIR) interaction partners

  1. PRN1 may play a critical role in cellular quercetin levels and influence light- or hormonal-directed early development.

  2. Arabidopsis mutants of the PRN1 gene, which is involved in abiotic and biotic signaling affecting phenylalanine-derived flavonoids, showed altered susceptibility to cryptoccocal infections, suggesting roles for this pathway in cryptococcal defense.

Mouse (Murine) Pirin (PIR) interaction partners

  1. Sod1(-/-) mice have a significantly elevated level of Pir mRNA in the spleen and kidney but not in the liver, heart, or/and brain.

Pirin (PIR) Protein Profile

Protein Summary

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with Pirin Proteins (PIR)

  • pirin (PIR)
  • pirin (PRN)
  • pirin (Pir)
  • pirin (pir)
  • pirin L homeolog (pir.L)
  • 2310042L19Rik protein
  • ATPIRIN1 protein
  • pirin protein
  • Pirnl protein
  • PRN1 protein
  • xpir protein
  • zgc:92778 protein

Protein level used designations for Pirin Proteins (PIR)

pirin , probable quercetin 2,3-dioxygenase PIR , probable quercetinase , iron-binding nuclear protein , pirin like

8544 Homo sapiens
825091 Arabidopsis thaliana
69656 Mus musculus
363465 Rattus norvegicus
436823 Danio rerio
379306 Xenopus laevis
480846 Canis lupus familiaris
790878 Bos taurus
100713331 Cavia porcellus
100514999 Sus scrofa
100350592 Oryctolagus cuniculus
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