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PIR encodes a member of the cupin superfamily. Additionally we are shipping Pirin Antibodies (47) and Pirin Kits (19) and many more products for this protein.
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Data suggest that only the Fe(III) form of pirin [not the Fe(II) form] enhances affinity of binding between p65 (show GORASP1 Proteins) and DNA in the pirin-p65 (show GORASP1 Proteins)-DNA supramolecular complex. (pirin = quercetin 2,3-dioxygenase; p65 (show GORASP1 Proteins) = RELA (show NFkBP65 Proteins) proto-oncogene (show RAB1A Proteins) NF-kappaB (show NFKB1 Proteins) subunit)
Pirin regulates E-cadherin independently of Bcl3-Slug signaling.
The NRF2 transcription factor binds to this element in vivo and drives the basal PIR expression.
Pirin is a newly identified binding partner of EAF2/U19 (show EAF2 Proteins) capable of down-regulating EAF2/U19 (show EAF2 Proteins) protein and alleviating its inhibition of prostate cancer cell survival/proliferation.
Data indicate that the R-shaped area composes the interface for pirin-NF-kappaB (show NFKB1 Proteins) binding that is responsible for modulation of NF-kappaB's DNA-binding properties.
pirin may have a relevant role in melanoma progression.
knockdown of pirin or treatment with the small molecule inhibited melanoma cell migration
This study aimed to examine genetic variations in the PIR gene by a comprehensive tagging method and its sex-specific effects on bone mineral density and osteoporotic risk.
An abnormal pattern of PIR sub-cellular localization is a characteristic feature of a subset of melanomas, and suggest it may represent a marker associated with disease progression.
Pirin downregulation is a feature of acute myeloid leukemia (show BCL11A Proteins) and leads to impairment of terminal myeloid differentiation.
PRN1 may play a critical role in cellular quercetin levels and influence light- or hormonal-directed early development.
Arabidopsis mutants of the PRN1 gene, which is involved in abiotic and biotic signaling affecting phenylalanine-derived flavonoids, showed altered susceptibility to cryptoccocal infections, suggesting roles for this pathway in cryptococcal defense.
Sod1(-/-) mice have a significantly elevated level of Pir mRNA in the spleen and kidney but not in the liver, heart, or/and brain.
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.
, probable quercetin 2,3-dioxygenase PIR
, probable quercetinase
, iron-binding nuclear protein
, pirin like