anti-Pituitary Tumor-Transforming 1 (PTTG1) Antibodies

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. Additionally we are shipping PTTG1 Proteins (17) and PTTG1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTTG1 9232 O95997
PTTG1 30939 Q9CQJ7
PTTG1 64193 P97613
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Top anti-PTTG1 Antibodies at antibodies-online.com

Showing 10 out of 90 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Anti-Securin antibody, Western blotting All lanes: Anti PTTG1  at 0.5ug/ml Lane 1: HELA Whole Cell Lysate at 40ug Lane 2: MCF-7 Whole Cell Lysate at 40ug Lane 3: SKOV Whole Cell Lysate at 40ug Lane 4: A375 Whole Cell Lysate at 40ug Predicted bind size: 22KD Observed bind size: 22KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from RAW264.7 cells, using PTTG Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PTTG Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HepG2/Jurkat/293 cells, using PTTG1 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HuvEc cells, using PTTG1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6274144 staining HepG2 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. ABIN6274144 staining MCF7 cells by ICC/IF. Cells were fixed with PFA and permeabilized in 0.1% saponin prior to blocking in 10% serum for 45 minutes at 37°C. The primary antibody was diluted 1/200 and incubated with the sample for 1 hour at 37°C. A Alexa Fluor 594 conjugated goat polyclonal to rabbit IgG (H+L), diluted 1/600 was used as secondary antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis on Jurkat and K562 cell lysate using PTTG1 Antibody,The lane on the left is treated with the antigen-specific peptide. Western blot analysis of extracts from various samples, using PTTG1 Antibody. Lane 1: 293 treated with blocking peptide. Lane 2: 293; Lane 3: hela; 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB Western blot analysis of extract of various cells, using PTTG1 antibody. Immunohistochemistry of paraffin-embedded human lung cancer using PTTG1 antibody at dilution of 1:100 (40x lens). 100 μL Log in to see 16 Days
$366.77
Details
Human Goat Un-conjugated IHC, IHC (p) Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of PTTG1 antibody (N-term) (ABIN391532) in Ramos cell line lysates (35 µg/lane). PTTG1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue with PTTG1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated IF, IHC (p), IP, WB 0.1 mg Log in to see 6 to 8 Days
$357.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of extracts from RAW264.7 cells, using PTTG antibody. ABIN6274290 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$390.77
Details

Top referenced anti-PTTG1 Antibodies

  1. Human Polyclonal PTTG1 Primary Antibody for IF, IHC (p) - ABIN391532 : Cui, Xu, Song, Zhao, Liu, Song: Pituitary tumor transforming gene: a novel therapeutic target for glioma treatment. in Acta biochimica et biophysica Sinica 2015 (PubMed)

  2. Human Polyclonal PTTG1 Primary Antibody for WB - ABIN3042643 : Zhang, Liu, Xu, Huang, Tan, Sun, Lu: Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in oral squamous cell carcinoma (OSCC) and promotes migration, invasion and epithelial-mesenchymal transition (EMT) in SCC15 cells. in Tumour biology 2014 (PubMed)

More Antibodies against PTTG1 Interaction Partners

Human Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. the short form of securin does not influence the expression of MYC transcriptional targets, such as TP53 and IL-8.

  2. Data strongly indicated that PTTG1 is a target gene of miR186 in osteosarcoma (OS) cells and is involved in miR186mediated suppressive effects of OS cells.

  3. Results show that PTTG1 oncoprotein overexpression may modulate cell proliferation-related regulators in myeloid leukemia.

  4. In ACTH-secreting pituitary tumors, IHC staining showed strong cytoplasmic and moderate nucleic PTTG immunoreactivity in 22 of 28 nonrecurrent tumors and in 21 of 27 recurrent tumors but no staining in the 2 normal pituitaries. PTTG was significantly increased in both the nonrecurrent and recurrent groups compared with normal pituitary glands, but there was no difference between the nonrecurrent and recurrent groups.

  5. Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.

  6. PTTG-1 oexpression in meningiomas were correlated with tumor grade and proliferation rate.

  7. Results found that PTTG1 expression was significantly increased in androgen-independent prostate cancer cells and, elucidates that interleukin-6/STAT3 activation can increase PTTG1 expression and, consequently, promote the resistance to androgen deprivation therapy in castration-resistant prostate cancer by inducing EMT and increasing the cancer stem cell population.

  8. we confirmed the oncogenic function of PTTG1 in BC and demonstrated that PTTG1 is a target of miR-146a-3p.

  9. PTTG1 is an independent prognostic factor and acts as an oncogene in colorectal cancer

  10. High PTTG1 expression is associated with aggressive meningiomas.

  11. These results indicate PTTG1 may be a valuable biomarker in ovarian cancer to predict sensitivity to saracatinib, and could form the basis of a targeted prospective saracatinib trial for ovarian cancer.

  12. A relatively stable genome in retinoblastoma tumor cells is maintained by TRb1 and TRb2-mediated PTTG1 inhibition, counteracting Rb-deficiency-related genomic instability.

  13. Findings indicate that PBF and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome.

  14. PTTG-mediated FGF2 upregulation is associated with more aggressive tumor features in patients with acromegaly. Also, locally produced estrogen through aromatization might have a role in this phenomenon.

  15. All these suggest that the MAP3K M1P site is a potential interacting partner of MAP3K SH3 domain, which may mediate the intermolecular recognition between hPTTG1 and MAP3K.

  16. that PTTG1 is a novel downstream target gene of androgen receptor and take part in prostate cancer proliferation and metastasis

  17. Knockdown of PTTG1 suppresses the growth and invasion of LAC cells through upregulation of the TGFbeta1/SMAD3 signaling.

  18. PTTG1 is correlated with non-small cell lung cancer (NSCLC) progression and as an independent poor prognostic factor in NSCLC patients.

  19. Our data indicate that securin expression may serve as a strong and independent prognosticator of breast cancer outcome

  20. PTTG1 mRNA expression levels in gastric tumor tissues were significantly higher than in the corresponding adjacent normal gastric mucosa.PTTG1 mRNA and protein expression are independent prognostic factors for gastric cancer patient survival.

Pig (Porcine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. PTTG1 is a new candidate maternal effect gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis

Mouse (Murine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. The findings show that maternal aging compromises the oocyte SAC-APC/C axis leading to a decrease in securin that ultimately causes sister chromatid cohesion loss.

  2. Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.

  3. High PTTG1 expression is associated with pituitary tumor development.

  4. PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.

  5. RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.

  6. these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.

  7. Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis

  8. PBF is the first protein to interact with the critical TH transporter MCT8 and modulate its function in vivo

  9. CSN3 and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 and Securin via APC/C.

  10. The genetically deleting Tff3 in mice altered down-regulated Pttg1 and up-regulated serpina3n expression, indicating a potential role of these factors during the development of presbyacusis.

  11. data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function

  12. Pituitary tumor transforming gene 1 (PTTG1), an oncogene, was the most up-regulated transcript in KLF6+/- liver. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6.

  13. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes.

  14. homologue disjunction in mouse oocytes is dependent on proteolysis of the separase inhibitor securin and cyclin B1

  15. Physiological functions of PTTG are revealed by PTTG-null mice who exhibit a variety of cell growth abnormalities including diabetes mellitus secondary to defective beta-cell proliferation. Review.

  16. Securin phosphorylation act redundantly to prevent sister chromatid separation.

  17. results suggest that Rae1 and Nup98 are temporal regulators of APC(Cdh1) that maintain euploidy by preventing unscheduled degradation of securin

  18. results suggest that the proteolysis of securin is dependent on ubiquitin-proteasome pathway and is necessary for the degradation of Rec8 during meiotic metaphase-to-anaphase transitions in oocytes

  19. PTTG1 and its binding protein PTTG binding factor are expressed in pituitary FS TtT/GF cells.

  20. PTTG1, an oncogene, is regulated by the liganded thyroid hormone receptor beta

PTTG1 Antigen Profile

Protein Summary

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Gene names and symbols associated with PTTG1

  • pituitary tumor-transforming 1 (PTTG1) antibody
  • pituitary tumor-transforming gene 1 (Pttg1) antibody
  • pituitary tumor-transforming 1 (Pttg1) antibody
  • securin, sister chromatid separation inhibitor (cut2) antibody
  • AW555095 antibody
  • C87862 antibody
  • EAP1 antibody
  • HPTTG antibody
  • Protein Cut2 antibody
  • Pttg antibody
  • PTTG1 antibody
  • Pttg3 antibody
  • Securin antibody
  • TUTR1 antibody

Protein level used designations for PTTG1

ESP1-associated protein 1 , pituitary tumor-transforming gene 1 protein , securin , tumor-transforming protein 1 , pituitary tumor-transforming protein 1 , pituitary tumor-transforming 1 , Pituitary tumor transforming , Pituitary tumor-transforming gene 1 protein , Cell untimely torn protein 2

GENE ID SPECIES
9232 Homo sapiens
397015 Sus scrofa
416158 Gallus gallus
479307 Canis lupus familiaris
508043 Bos taurus
696143 Macaca mulatta
30939 Mus musculus
64193 Rattus norvegicus
462238 Pan troglodytes
100848911 Bos taurus
2539641 Schizosaccharomyces pombe 972h-
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