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The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. Additionally we are shipping PTTG1 Antibodies (77) and PTTG1 Proteins (15) and many more products for this protein.
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High PTTG1 expression is associated with aggressive meningiomas.
These results indicate PTTG1 may be a valuable biomarker in ovarian cancer to predict sensitivity to saracatinib, and could form the basis of a targeted prospective saracatinib trial for ovarian cancer.
A relatively stable genome in retinoblastoma tumor cells is maintained by TRb1 (show TRIB1 ELISA Kits) and TRb2 (show TRIB2 ELISA Kits)-mediated PTTG1 inhibition, counteracting Rb-deficiency-related genomic instability.
Findings indicate that PBF (show PTTG1IP ELISA Kits) and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome.
PTTG-mediated FGF2 (show FGF2 ELISA Kits) upregulation is associated with more aggressive tumor features in patients with acromegaly. Also, locally produced estrogen through aromatization might have a role in this phenomenon.
All these suggest that the MAP3K M1P site is a potential interacting partner of MAP3K SH3 domain (show ITSN1 ELISA Kits), which may mediate the intermolecular recognition between hPTTG1 and MAP3K.
that PTTG1 is a novel downstream target gene of androgen receptor (show AR ELISA Kits) and take part in prostate cancer proliferation and metastasis
Knockdown of PTTG1 suppresses the growth and invasion of LAC (show LCT ELISA Kits) cells through upregulation of the TGFbeta1 (show TGFB1 ELISA Kits)/SMAD3 (show SMAD3 ELISA Kits) signaling.
PTTG1 is correlated with non-small cell lung cancer (NSCLC) progression and as an independent poor prognostic factor in NSCLC patients.
Our data indicate that securin expression may serve as a strong and independent prognosticator of breast cancer outcome
PTTG1 is a new candidate maternal effect (show NLRP5 ELISA Kits) gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis
High PTTG1 expression is associated with pituitary tumor development.
PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.
RasGrf1 (show RASGRF1 ELISA Kits) is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.
these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.
Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis
PBF (show PTTG1IP ELISA Kits) is the first protein to interact with the critical TH transporter MCT8 (show MCT8 ELISA Kits) and modulate its function in vivo
CSN3 (show CSN3 ELISA Kits) and CSN5 (show COPS5 ELISA Kits) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (show CCNB1 ELISA Kits) and Securin via APC (show APC ELISA Kits)/C.
The genetically deleting Tff3 (show TFF3 ELISA Kits) in mice altered down-regulated Pttg1 and up-regulated serpina3n (show SERPINA3N ELISA Kits) expression, indicating a potential role of these factors during the development of presbyacusis.
data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function
Pituitary tumor transforming gene 1 (PTTG1), an oncogene (show RAB1A ELISA Kits), was the most up-regulated transcript in KLF6 (show KLF6 ELISA Kits)+/- liver. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6 (show KLF6 ELISA Kits).
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
pituitary tumor-transforming protein 1
, pituitary tumor-transforming 1
, ESP1-associated protein 1
, pituitary tumor-transforming gene 1 protein
, tumor-transforming protein 1
, Pituitary tumor transforming