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The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. Additionally we are shipping PTTG1 Antibodies (88) and PTTG1 Proteins (17) and many more products for this protein.
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Data strongly indicated that PTTG1 is a target gene of miR186 in osteosarcoma (OS) cells and is involved in miR186mediated suppressive effects of OS cells.
Results show that PTTG1 oncoprotein overexpression may modulate cell proliferation-related regulators in myeloid leukemia (show BCL11A ELISA Kits).
In ACTH (show POMC ELISA Kits)-secreting pituitary tumors, IHC staining showed strong cytoplasmic and moderate nucleic PTTG immunoreactivity in 22 of 28 nonrecurrent tumors and in 21 of 27 recurrent tumors but no staining in the 2 normal pituitaries. PTTG was significantly increased in both the nonrecurrent and recurrent groups compared with normal pituitary glands, but there was no difference between the nonrecurrent and recurrent groups.
Smurf1 (show SMURF1 ELISA Kits) interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.
PTTG-1 oexpression in meningiomas were correlated with tumor grade and proliferation rate.
Results found that PTTG1 expression was significantly increased in androgen-independent prostate cancer cells and, elucidates that interleukin-6 (show IL6 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) activation can increase PTTG1 expression and, consequently, promote the resistance to androgen deprivation therapy in castration-resistant prostate cancer by inducing EMT (show ITK ELISA Kits) and increasing the cancer stem cell population.
we confirmed the oncogenic function of PTTG1 in BC and demonstrated that PTTG1 is a target of miR-146a-3p.
PTTG1 is an independent prognostic factor and acts as an oncogene (show RAB1A ELISA Kits) in colorectal cancer
High PTTG1 expression is associated with aggressive meningiomas.
These results indicate PTTG1 may be a valuable biomarker in ovarian cancer to predict sensitivity to saracatinib, and could form the basis of a targeted prospective saracatinib trial for ovarian cancer.
PTTG1 is a new candidate maternal effect gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis
The findings show that maternal aging compromises the oocyte SAC (show ADCY10 ELISA Kits)-APC (show APC ELISA Kits)/C axis leading to a decrease in securin that ultimately causes sister chromatid cohesion loss.
High PTTG1 expression is associated with pituitary tumor development.
PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.
RasGrf1 (show RASGRF1 ELISA Kits) is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.
these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.
Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis
PBF is the first protein to interact with the critical TH transporter MCT8 and modulate its function in vivo
CSN3 (show CSN3 ELISA Kits) and CSN5 (show COPS5 ELISA Kits) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (show CCNB1 ELISA Kits) and Securin via APC (show APC ELISA Kits)/C.
The genetically deleting Tff3 (show TFF3 ELISA Kits) in mice altered down-regulated Pttg1 and up-regulated serpina3n (show SERPINA3N ELISA Kits) expression, indicating a potential role of these factors during the development of presbyacusis.
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
ESP1-associated protein 1
, pituitary tumor-transforming gene 1 protein
, tumor-transforming protein 1
, pituitary tumor-transforming protein 1
, pituitary tumor-transforming 1
, Pituitary tumor transforming
, Pituitary tumor-transforming gene 1 protein
, Cell untimely torn protein 2