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PKP1 encodes a member of the arm-repeat (armadillo) and plakophilin gene families.
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PKP1 has roles in desmosome and tight junction function and in growth control, a function that is crucial in wound healing and epidermal carcinogenesis
This approach identified a key signaling event, phosphorylation of a desmosome component, PKP1 (plakophilin-1) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiation.
These results implicate the participation of PKP1 in early tooth morphogenesis as an effector of canonical Wnt (show WNT2 ELISA Kits) signaling that controls ameloblast differentiation via regulation of the cell adhesion complex
Collectively, altered expression of PKP1 and SPOCK1 (show SPOCK1 ELISA Kits) appears to be a frequent and critical event in prostate cancer
cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein (show RBP31 ELISA Kits) particles and act as posttranscriptional regulators of gene expression.
Plakophilin-1 has a role in protecting keratinocytes from pemphigus vulgaris (show DSG3 ELISA Kits) IgG by forming calcium-independent desmosomes
Data indicate that upon activation of growth factor signaling, plakophilin 1 switches from a desmosome-associated growth-inhibiting to a cytoplasmic proliferation-promoting function.
In breast cancer, compared with normal tissue, PKP1 and PKP2 expressions were indifferent (P > 0.05), but PKP3 expression was significantly increased
PKP1 loss secondary to promoter methylation, as well as other mechanisms, may promote the progression of Barrett's esophagus to esophageal adenocarcinoma in a subset of patients via decreased desmosome assembly and increased cell motility
both loss of PKP1 and up-regulation of PKP3 expression are biologically important events in prostate cancer and are associated with a more aggressive phenotype
These findings identify PKP1 as a regulator of translation and proliferation via modulation of eIF4A1 activity.
the clinicopathologic features attest to the significant role of PKP1 in stabilization of desmosome structure and function, predominantly in the spinous layers of the epidermis
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene.
, band 6 protein
, band 6
, band-6 protein