Plakophilin 1 (PKP1) ELISA Kits

Mouse (Murine) Plakophilin 1 (PKP1) interaction partners

1. Pkp1 regulates desmoglein membrane availability, whereas Pkp1 but not Pkp3 is required for desmoglein 3 clustering.

2. PKP1 was identified as a new potential tumor suppressor in human melanoma.

3. PKP1 has roles in desmosome and tight junction function and in growth control, a function that is crucial in wound healing and epidermal carcinogenesis

4. This approach identified a key signaling event, phosphorylation of a desmosome component, PKP1 (plakophilin-1) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiation.

Human Plakophilin 1 (PKP1) interaction partners

1. 14-3-3gamma associated primarily with cytoplasmic PKP1 phosphorylated at S155 and destabilized intercellular cohesion of keratinocytes by reducing its incorporation into desmosomes.

2. These results implicate the participation of PKP1 in early tooth morphogenesis as an effector of canonical Wnt signaling that controls ameloblast differentiation via regulation of the cell adhesion complex

3. Collectively, altered expression of PKP1 and SPOCK1 appears to be a frequent and critical event in prostate cancer

4. cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression.

5. Plakophilin-1 has a role in protecting keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes

6. Data indicate that upon activation of growth factor signaling, plakophilin 1 switches from a desmosome-associated growth-inhibiting to a cytoplasmic proliferation-promoting function.

7. In breast cancer, compared with normal tissue, PKP1 and PKP2 expressions were indifferent (P > 0.05), but PKP3 expression was significantly increased

8. PKP1 loss secondary to promoter methylation, as well as other mechanisms, may promote the progression of Barrett's esophagus to esophageal adenocarcinoma in a subset of patients via decreased desmosome assembly and increased cell motility

9. both loss of PKP1 and up-regulation of PKP3 expression are biologically important events in prostate cancer and are associated with a more aggressive phenotype

10. in addition to mediating desmosome assembly, the nuclear pool of Pkp can influence cell survival by interactions with DNA

11. These findings identify PKP1 as a regulator of translation and proliferation via modulation of eIF4A1 activity.

12. the clinicopathologic features attest to the significant role of PKP1 in stabilization of desmosome structure and function, predominantly in the spinous layers of the epidermis

13. Genotype-phenotype correlation in skin fragility-ectodermal dysplasia syndrome resulting from mutations in plakophilin 1. Homozygous intron 11 donor splice site mutation in the plakophilin 1 gene, 2021+1 G>A.

14. The PKP1 null patients showed poorly developed inner and outer desmosomal plaques and reductions in the lower suprabasal layer desmosome size and number so pkp1 has a recruiting and stabilizing role in desmosome formation

15. plakophilin 1 has a key role in increasing desmosomal protein content, in desmosome assembly, and in regulating cell migration

16. crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in desmosomes

17. Co-expression of a classical cadherin (N-cadherin) and plakophilin-1/ER in A431D cells resulted in punctate desmoplakin staining at cell-cell borders

18. Compound heterozygosity for new splice site mutations in the plakophilin 1 gene (PKP1) in a Chinese case of ectodermal dysplasia-skin fragility syndrome

19. the Plakophilin-1 carboxyl terminus recruits it to plasma membrane, whereas amino terminus recruits desmoplakin and promotes desmosome assembly

20. The Ki67+ proliferation index was inversely correlated with desmoplakin and plakophilin-1 during cervical squamous cell carcinogenesis