Plakophilin 3 Proteins (PKP3)

PKP3 encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Additionally we are shipping Plakophilin 3 Antibodies (92) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PKP3 11187 Q9Y446
PKP3 56460 Q9QY23
Rat PKP3 PKP3 293619  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Plakophilin 3 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details

PKP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Plakophilin 3 (PKP3) Interaction Partners

Human Plakophilin 3 (PKP3) interaction partners

  1. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.

  2. Children with low 25-hydroxyvitamin D and TMEM16J rs7111432-AA or PKP3 rs10902158-GG polymorphisms were at increased risk for tuberculosis or death.

  3. Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2), plakophilin 2 (PKP2), and plakophilin 3 (PKP3) are involved in desmosome formation in epithelial cells; DSC2 participates in desmosome formation in absence of desmoglein 2 (DSG2).

  4. The results suggest that MMP7 over-expression may be one of the mechanisms by which PKP3 loss leads to increased cell invasion and tumor formation.

  5. reactive oxygen species (ROS) trigger the c-Src kinase-mediated tyrosine (Tyr)-195 phosphorylation of PKP3.

  6. These findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its functional association with Rap1.

  7. cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression.

  8. Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of PKP3 and its detachment from DSG3.

  9. The study describes a new protein variant of the human PKP3 gene, namely PKP3b, which differs from the published PKP3a only at the amino-terminus by the splicing in of the newly identified exon 1b.

  10. stratifin plays a role in regulating plakophilin-3 incorporation into the desmosomal plaque by forming a plakophilin-3 stratifin complex in the cytosol and thereby affecting desmosome dynamics in squamous epithelial cells.

  11. In breast cancer, compared with normal tissue, PKP1 and PKP2 expressions were indifferent (P > 0.05), but PKP3 expression was significantly increased

  12. Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis.

  13. These results demonstrate a strong association of single-nucleotide polymorphisms in the PKP3-SIGIRR-TMEM16J gene region and tuberculosis in discovery and validation cohorts.

  14. plakoglobin and E-cadherin recruit plakophilin3 to the cell border to initiate desmosome formation

  15. loss of PKP3 expression during gastric adenocarcinoma progression may indicate an invasive phenotype.

  16. both loss of PKP1 and up-regulation of PKP3 expression are biologically important events in prostate cancer and are associated with a more aggressive phenotype

  17. PKP3 mRNA can be used as a marker of subclinical disease in gastrointestinal cancer and thus holds potential clinical relevance as a predictor for disease outcome

  18. PKP3, whose desmosomal expression and protein interactions are broader than those of PKP1 and -2, is a unique multiprotein binding element in many epithelial desmosomes.

  19. Cytoplasmic PKP3 is constitutively associated with RNA-binding proteins and indicate an involvement in processes of translation and RNA metabolism.

  20. The transcriptional repression of PKP3 by ZEB1 contributes to ZEB1-mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition.

Mouse (Murine) Plakophilin 3 (PKP3) interaction partners

  1. data highlight a novel role for hematopoietic PKP3 in the regulation of both locally and systemically induced immune responses.

  2. PKP3 gene down regulation is associated with bladder cancer invasion.

  3. PKP3 plays a critical role in morphogenesis of HFs and shafts and in limiting inflammatory responses in the skin

Plakophilin 3 (PKP3) Protein Profile

Protein Summary

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.

Gene names and symbols associated with Plakophilin 3 Proteins (PKP3)

  • plakophilin 3a (pkp3a)
  • plakophilin 3 (PKP3)
  • plakophilin-3 (LOC450921)
  • plakophilin 3 L homeolog (pkp3.L)
  • plakophilin 3 (Pkp3)
  • 2310056L12Rik protein
  • PKP3 protein
  • wu:fa97f09 protein
  • wu:fk69a12 protein
  • zgc:136656 protein

Protein level used designations for Plakophilin 3 Proteins (PKP3)

plakophilin 3 , plakophilin-3-like , plakophilin 3b , plakophilin-3

GENE ID SPECIES
368397 Danio rerio
422994 Gallus gallus
450921 Pan troglodytes
100412402 Callithrix jacchus
446427 Xenopus laevis
11187 Homo sapiens
516247 Bos taurus
56460 Mus musculus
483399 Canis lupus familiaris
293619 Rattus norvegicus
Selected quality suppliers for Plakophilin 3 Proteins (PKP3)
Did you look for something else?