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PKP3 encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Additionally we are shipping Plakophilin 3 Antibodies (93) and many more products for this protein.
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PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 (show DSC2 Proteins) levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.
Children with low 25-hydroxyvitamin D and TMEM16J (show ANO9 Proteins) rs7111432-AA or PKP3 rs10902158-GG polymorphisms were at increased risk for tuberculosis or death.
Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2 (show DSC2 Proteins)), plakophilin 2 (PKP2), and plakophilin 3 (PKP3) are involved in desmosome formation in epithelial cells; DSC2 (show DSC2 Proteins) participates in desmosome formation in absence of desmoglein 2 (DSG2 (show DSG2 Proteins)).
The results suggest that MMP7 (show MMP7 Proteins) over-expression may be one of the mechanisms by which PKP3 loss leads to increased cell invasion and tumor formation.
reactive oxygen species (ROS (show ROS1 Proteins)) trigger the c-Src kinase (show CSK Proteins)-mediated tyrosine (Tyr (show TYR Proteins))-195 phosphorylation of PKP3.
These findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its functional association with Rap1.
cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression.
Pemphigus vulgaris (show DSG3 Proteins) autoimmune globulin induces Src (show SRC Proteins)-dependent tyrosine-phosphorylation of PKP3 and its detachment from DSG3 (show DSG3 Proteins).
The study describes a new protein variant of the human PKP3 gene, namely PKP3b, which differs from the published PKP3a only at the amino-terminus by the splicing in of the newly identified exon 1b.
stratifin (show SFN Proteins) plays a role in regulating plakophilin-3 incorporation into the desmosomal plaque by forming a plakophilin-3 stratifin (show SFN Proteins) complex in the cytosol and thereby affecting desmosome dynamics in squamous epithelial cells.
data highlight a novel role for hematopoietic PKP3 in the regulation of both locally and systemically induced immune responses.
PKP3 gene down regulation is associated with bladder cancer invasion.
PKP3 plays a critical role in morphogenesis of HFs and shafts and in limiting inflammatory responses in the skin
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.
, plakophilin 3b