Plakophilin 3 Proteins (PKP3)

Human Plakophilin 3 (PKP3) interaction partners

1. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 (show DSC2 Proteins) levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.

2. Children with low 25-hydroxyvitamin D and TMEM16J (show ANO9 Proteins) rs7111432-AA or PKP3 rs10902158-GG polymorphisms were at increased risk for tuberculosis or death.

3. Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2 (show DSC2 Proteins)), plakophilin 2 (PKP2), and plakophilin 3 (PKP3) are involved in desmosome formation in epithelial cells; DSC2 (show DSC2 Proteins) participates in desmosome formation in absence of desmoglein 2 (DSG2 (show DSG2 Proteins)).

4. The results suggest that MMP7 (show MMP7 Proteins) over-expression may be one of the mechanisms by which PKP3 loss leads to increased cell invasion and tumor formation.

5. reactive oxygen species (ROS (show ROS1 Proteins)) trigger the c-Src kinase (show CSK Proteins)-mediated tyrosine (Tyr (show TYR Proteins))-195 phosphorylation of PKP3.

6. These findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its functional association with Rap1.

7. cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression.

8. Pemphigus vulgaris (show DSG3 Proteins) autoimmune globulin induces Src (show SRC Proteins)-dependent tyrosine-phosphorylation of PKP3 and its detachment from DSG3 (show DSG3 Proteins).

9. The study describes a new protein variant of the human PKP3 gene, namely PKP3b, which differs from the published PKP3a only at the amino-terminus by the splicing in of the newly identified exon 1b.

10. stratifin (show SFN Proteins) plays a role in regulating plakophilin-3 incorporation into the desmosomal plaque by forming a plakophilin-3 stratifin (show SFN Proteins) complex in the cytosol and thereby affecting desmosome dynamics in squamous epithelial cells.

Mouse (Murine) Plakophilin 3 (PKP3) interaction partners

1. data highlight a novel role for hematopoietic PKP3 in the regulation of both locally and systemically induced immune responses.

2. PKP3 gene down regulation is associated with bladder cancer invasion.

3. PKP3 plays a critical role in morphogenesis of HFs and shafts and in limiting inflammatory responses in the skin