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PF4 encodes a member of the CXC chemokine family.
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Human PF4 ELISA Kit for Sandwich ELISA - ABIN625077
Thasneem, Sajeesh, Sharma: Glucosylated polymeric nanoparticles: a sweetened approach against blood compatibility paradox. in Colloids and surfaces. B, Biointerfaces 2013
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Mouse (Murine) PF4 ELISA Kit for Sandwich ELISA - ABIN415576
Sotnikov, Veremeyko, Starossom, Barteneva, Weiner, Ponomarev: Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. in PLoS ONE 2013
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Rat (Rattus) PF4 ELISA Kit for Sandwich ELISA - ABIN416291
Tang, Sun, Wu, Zhong, Liu, Xiao, Tao, Zhao, Gu: Propofol lowers serum PF4 level and partially corrects hypercoagulopathy in endotoxemic rats. in Biochimica et biophysica acta 2010
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Human PF4 ELISA Kit for Sandwich ELISA - ABIN366736
Wang, Qin, Nie, Sun, Ran, Zhao: Direct synthesis of heparin-like poly(ether sulfone) polymer and its blood compatibility. in Acta biomaterialia 2013
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Human PF4 ELISA Kit for Sandwich ELISA - ABIN415027
Hoetzenecker, Assinger, Lichtenauer, Mildner, Schweiger, Starlinger, Jakab, Berényi, Pavo, Zimmermann, Gabriel, Plass, Gyöngyösi, Volf, Ankersmit et al.: Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and ... in Basic research in cardiology 2012
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Mouse (Murine) PF4 ELISA Kit for Sandwich ELISA - ABIN625172
Thielmann, Stegner, Kraft, Hagedorn, Krohne, Kleinschnitz, Stoll, Nieswandt: Redundant functions of phospholipases D1 and D2 in platelet α-granule release. in Journal of thrombosis and haemostasis : JTH 2014
Pig (Porcine) PF4 ELISA Kit for Sandwich ELISA - ABIN834811
Kehara, Takano, Ohashi, Terasaki, Amano: Platelet Function During Cardiopulmonary Bypass Using Multiple Electrode Aggregometry: Comparison of Centrifugal and Roller Pumps. in Artificial organs 2014
PF4 was produced by Ly6G+CD11b (show ITGAM ELISA Kits)+ immature myeloid cells in the early stage premetastatic lungs, and decreased during metastatic progression.
The CXCL4 monomer acts as the minimal active unit for interacting with CXCR3 (show CXCR3 ELISA Kits) N-Terminal Sulfated (show SULF1 ELISA Kits) Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.
These findings support PF4 as a cancer-enhancing endocrine signal that controls discrete aspects of bone marrow hematopoiesis and tumor microenvironment.
data support that increased levels of circulating CXCL4 may contribute to immune dysregulation through the modulation of dendritic cell differentiation
Endometrial CXCL4 mRNA concentrations were significantly increased during menstruation. In women with heavy menstrual bleeding, CXCL4 was reduced in endothelial cells during the menstrual phase compared with women with normal menstrual bleeding. These data implicate CXCL4 in endometrial repair after menses.
Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.
These data demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal HSC/HPC cell fates, including survival and self-renewal.
The major aim of this review article was to evaluate the role of CXCL4 in hematological malignancies, promotion of HSC quiescence as well as BM niche cells.
binding of PF4 to perlecan (show HSPG2 ELISA Kits) was found to inhibit both FGF2 (show FGF2 ELISA Kits) signaling and platelet activation
CXCL4 plays an important role in pancreatic inflammation
these data demonstrate that PF4 has an important role in increasing B cell differentiation in the bone marrow environment
these results identify CXCL4 as a vital immunoregulatory chemokine (show CCL1 ELISA Kits) essential for protecting mice against influenza A virus infection, especially as it affects the development of lung injury and neutrophil mobilization to the inflamed lung
These results indicate that CXCL4 is a novel Ni-binding protein that augments Ni allergy at the elicitation and sensitization phases. This is the first study to demonstrate that the Ni-binding protein augments Ni allergy in vivo.
Platelet-derived CXCL7 (show PPBP ELISA Kits) and CXCL4 contribute to the pathogenesis of acute lung injury.
Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage
PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.
Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.
C-X-C motif chemokine 4
, chemokine (C-X-C motif) ligand 4
, platelet factor 4 (chemokine (C-X-C motif) ligand 4)
, platelet factor 4