Platelet Factor 4 (PF4) ELISA Kits

Human Platelet Factor 4 (PF4) interaction partners

1. PF4 was produced by Ly6G+CD11b (show ITGAM ELISA Kits)+ immature myeloid cells in the early stage premetastatic lungs, and decreased during metastatic progression.

2. The CXCL4 monomer acts as the minimal active unit for interacting with CXCR3 (show CXCR3 ELISA Kits) N-Terminal Sulfated (show SULF1 ELISA Kits) Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.

3. These findings support PF4 as a cancer-enhancing endocrine signal that controls discrete aspects of bone marrow hematopoiesis and tumor microenvironment.

4. data support that increased levels of circulating CXCL4 may contribute to immune dysregulation through the modulation of dendritic cell differentiation

5. Endometrial CXCL4 mRNA concentrations were significantly increased during menstruation. In women with heavy menstrual bleeding, CXCL4 was reduced in endothelial cells during the menstrual phase compared with women with normal menstrual bleeding. These data implicate CXCL4 in endometrial repair after menses.

6. Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.

7. These data demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal HSC/HPC cell fates, including survival and self-renewal.

8. The major aim of this review article was to evaluate the role of CXCL4 in hematological malignancies, promotion of HSC quiescence as well as BM niche cells.

9. binding of PF4 to perlecan (show HSPG2 ELISA Kits) was found to inhibit both FGF2 (show FGF2 ELISA Kits) signaling and platelet activation

10. CXCL4 plays an important role in pancreatic inflammation

Mouse (Murine) Platelet Factor 4 (PF4) interaction partners

1. PF4 was produced by Ly6G+CD11b (show ITGAM ELISA Kits)+ immature myeloid cells in the early stage premetastatic lungs, and decreased during metastatic progression.

2. These data demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal HSC/HPC cell fates, including survival and self-renewal.

3. Platelet-derived CXCL7 (show PPBP ELISA Kits) and CXCL4 contribute to the pathogenesis of acute lung injury.

4. CXCL4 plays an important role in pancreatic inflammation

5. Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage

6. PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.

7. Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.

8. Data indicate that platelet factor 4 (PF4) is involved directly in liver innate immune response against ischaemia-reperfusion injury (IRI) by regulating Th17 cell differentiation.

9. CXCL4 regulates hematopoietic stem cell cell cycle activity.

10. Platelet factor 4 has a role in regulating Th17 differentiation and cardiac allograft rejection