Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 6 Proteins (PLEKHG6)

Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Additionally we are shipping PLEKHG6 Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLEKHG6 55200 Q3KR16
PLEKHG6 213522 Q8R0J1
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Top PLEKHG6 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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PLEKHG6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 6 (PLEKHG6) Interaction Partners

Human Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 6 (PLEKHG6) interaction partners

  1. Intramolecular interactions between MyoGEF domains act as an autoinhibitory mechanism for the regulation of MyoGEF functions.

  2. Taken together, these results suggest that aurora B (show AURKB Proteins) coordinates with Plk1 to regulate MyoGEF activation and localization, thus contributing to the regulation of cytokinesis.

  3. GIPC1 (show GIPC1 Proteins)-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.

  4. ezrin (show EZR Proteins) allows the local activation of RhoG (show RHOG Proteins) at the apical pole of epithelial cells by recruiting upstream and downstream regulators of RhoG (show RHOG Proteins) and that both PLEKHG6 and ezrin (show EZR Proteins) are required for efficient macropinocytosis

  5. Plk1 can regulate MyoGEF activity and localization, contributing to the regulation of cytokinesis

  6. MyoGEF cooperates with nonmuscle myosin IIA to regulate the polarity and invasion activity of breast cancer cells through activation of RhoA (show RHOA Proteins) and RhoC (show RHOC Proteins).

Mouse (Murine) Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 6 (PLEKHG6) interaction partners

  1. GIPC1 (show GIPC1 Proteins)-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.

PLEKHG6 Protein Profile

Protein Summary

Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Gene names and symbols associated with PLEKHG6

  • pleckstrin homology and RhoGEF domain containing G6 (PLEKHG6)
  • pleckstrin homology domain containing, family G (with RhoGef domain) member 6 (Plekhg6)
  • BC026778 protein
  • Gm155 protein
  • MyoGEF protein

Protein level used designations for PLEKHG6

PH domain-containing family G member 6 , myosin interacting guanine nucleotide exchange factor , myosin-interacting guanine nucleotide exchange factor , pleckstrin homology domain-containing family G member 6

GENE ID SPECIES
55200 Homo sapiens
213522 Mus musculus
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